Knowde Enhanced TDS
Identification & Functionality
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- Skin Care Applications
- ANTI-OXIDATION AND ANTI-AGING
ANTI-OXIDATION
Phytomoist inhibits the action of active oxygen and helps to prevent the aging of skin SOD* activity of the skin cells was increased by an addition of Phytomoist to the cultivation medium.
Method
Phytomoist was added to the culture medium cultivating keratinocyte or fibroblast isolated from rat skin. After cultivating 24 hrs. at 37 degrees C in 5%
CO2, SOD activity was measured.
1) Keratinocyte
When added more than 0.1% of Phytomoist, increase of SOD activity was observed.
2) Fibroblast
When added more than 0.5& of Phytomoist, increase of SOD activity was observed. (*SOD: SuperOxide Dismutase)ANTI-AGING
Phytomoist suppresses peroxidation of the cellular lipids and helps to prevent the aging of the skin.Phytomoist added to the cultivation medium suppressed lipid peroxidation in the skin cells.
Method
Phytomoist was added to the culture medium cultivating keratinocyte or fibroblast isolated from rat skin. After cultivating 24 hrs. at 37 degrees C in
5% CO2, generated MDA* was measured as a level of peroxidized lipids by TBA** method.
1) Keratinocyte
When added more than 0.1% of Phytomoist, peoxidized lipids in the cell culture decreased significantly.
2) Fibroblast
When added more than 0.5% ofPhytomoist, peroxidized lipids in the cell culture decreased significantly.
(*MDA: Malondialdehyde) (**TBA: Thiobarbituric acid)- Mode of Action
Phytomoist is not heat sensitive, but as with most actives it is recommended that it be added to the water phase of formulations below 50C. For W/O emulsions, add to water phase before emulsifying.
MOISTURIZATION STUDY
ELECTROCONDUCTIVITY-NOVAMETER
A Nova Dermal Phase Meter, Model DPM 9003 (Nova, Technology Corp., Gloucester, MA) was used to obtain measurements of skin surface impedance to determine electroconductivity of the treatment sites. This meter provides a relative measure of the retained water content of the skin as a function of the skin’s dielectric value. Skin impedance was recorded automatically when equilibrium was achieved.- Mode of Action
Tremella is a polysaccharide that is very hygroscopic and in combination with glycerin they completely hydrate the epidermis which renders the skin very permeable to transder-mal penetration of smaller molecules. Once skin is hydrated, Betaine, which is a very small amino acid derivative easily
penetrates the epidermis and permeates the stratum corneum due to it’s osmolytic properties. It is then taken up by Keratinocytes through specific betaine transporters to restore water balance in the cells. Betaine also improves tight junction integrity thus preventing water loss from the skin.