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Nicobrand Nicotine USP/EP

Nicobrand Nicotine USP/EP distilled from a natural product to AEMSA Nicotine Standards. Nicotine is produced in the bespoke manufacturing suite under cGMP conditions in Coleraine. Nicotine USP/EP is a colorless to straw colored liquid, extracted from the tobacco leaf and manufactured to meet both the USP and Ph Eur pharmacopeia standards.

Chemical Name: Nicotine

Certifications & Compliance: European Pharmacopeia (Ph. Eur.), United States Pharmacopeia (USP), cGMP

Technical Data Sheet
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Knowde Enhanced TDS

Identification & Functionality

Chemical Name
CAS No.
54-11-5
EC No.
200-193-3
Appearance
  1. Appearance: Colorless or brownish viscous liquid.
  2. Color: Test solution is not more intensely colored than reference solution Y5, BY5 or R5.
  3. Clarity: Test solution is clear.
Identification
  1. (HPLC) Retention time of the major peak in the Sample solution corresponds to that of the Standard Solution.
  2. IR Spectrum must be comparable to that of nicotine reference spectrum.
  3. Complies with specific optical rotation test using anhydrous ethanol at 20°C.

Applications & Uses

Properties

Physical Form
Typical Properties
ValueUnitsTest Method / Conditions
Specific Optical Rotation (25°C)-130 to -143°
Specific Optical Rotation (20°C)-140 to -152°
Water Contentmax. 0.5%
Heavy Metals (Colour Not Darker Than Standard)max. 0.002%
Assay by Non-Aqueous Titration (Anhydrous Substance)99.0 - 101.0%

Regulatory & Compliance

Technical Details & Test Data

Chromatographic Purity (HPLC)
Nicotine N'-oxide: ≤ 0.3%
Cotinine: ≤ 0.3%
Nornicotine: ≤ 0.3%
Anatabine: ≤ 0.3%
Myosmine: ≤ 0.3%
Anabasine: ≤ 0.3%
ß-Nicotyrine: ≤ 0.3%
Any other impurity: ≤ 0.10%
Sum of all impurities: ≤ 0.8%

Packaging & Availability

Packaging
Product Batch Quantities Pack Size
Nicotine USP/EP Up to 500kg 1kg and 25kg