KoVidone® VA64 Copovidone

Identification & Functionality

Chemical Name

Copovidone

Pharma & Nutraceuticals Functions

Binder,

Coating System,

Controlled Release Agent,

Film Former,

Solubilizer,

Taste Masker

CAS No.

25086-89-9

EC No.

607-540-1

Technologies

Pharmaceuticals & Nutraceuticals

Product Families

Pharmaceuticals & Nutraceuticals — Excipients

Binders & Disintegrants,

Flavors & Taste Maskers,

Modified & Controlled Release,

Pharmaceutical Coatings,

Solvents & Solubilizers

Features & Benefits

Product Highlights

• Hygroscopic capacity lower than KoVidone^® K30.
• Soluble in water, alcohol and many other organic solvents.
• Glass transition temperature(Tg) lower than KoVidone^® K30.
• Forms transparent,
• water removable films.

Applications & Uses

Markets

Healthcare & Pharma

Applications

Healthcare & Pharma — Drug Delivery & Care Solutions

Oral,

Topical

Dosage Form

Capsules,

Dispersions,

Granules,

Spray,

Tablets

Manufacturing Technology

Direct Compression,

Dry Granulation,

Wet Granulation

Recommended Uses and Known Applications

• Water soluble tablet binder; suitable for wet or dry granulation and direct compression processes, improves particle compressibility.
• Film-former; permeable film coating for tablet and sugar coatings to protect against splitting, decrease moisture sensitivity and provide good film adhesiveness, elasticity, and hardness.
• Porogenic agent; for use in taste-masking and component of the matrix material used in controlled-release formulation.
• Solubilizing agents; for solid dispersion processes to enhancing bioavailability and improve drug solubility.

Properties

Physical Form

Powder,

Solid

Typical Properties

	Value	Units	Test Method / Conditions
The content of vinyl acetate	35.3-41.0	%	—
K value	25.2-30.8 (Copovidone 28)	—	—
K value	27.0-33.0 (Copovidone 30	—	—

Regulatory & Compliance

Certifications & Compliance

cGMP