company tower banner
NNB Nutrition USA Company Logo
GlucoVantage® is the first commercially available brand of Dihydroberberine (DHB), which is an active metabolite of berberine. Berberine has been shown to optimize blood sugar, improving insulin sensitivity and body composition. Dihydroberberine solves berberine’s limitations of low bioavailability and GI distress.

Physical Form: Capsules, Powder, Solid

Labeling Claims: Allergen-free, Kosher, Naturally Derived, Non-GMO, Plant-Based, Vegan

Certifications & Compliance: GMP, Hazard Analysis Critical Control Point (HACCP), ISO 9001, Kosher, NSF Approved, Non-GMO Project Verified, Vegan

Features: Blood Glucose Management, Cost Effective, Excellent Bioavailability, Promotes Healthy Gastrointestinal Tract, Rapid Absorption, Reduce Blood Sugar Levels, Reduction in Blood Glucose Level

Functions: Supplement

    Knowde Enhanced TDS

    Identification & Functionality

    Food Ingredients Functions
    Pharma & Nutraceuticals Functions
    Technologies
    Chemical Structure

    GlucoVantage® - Chemical Structure

    Dihydroberberine (DHB) is a metabolite of berberine. Interestingly, gut microbes reduce berberine into its tissue-read form of DHB, which is then converted back to berberine after absorption in intestinal tissues.

    In other words, supplementation with DHB bypasses the rate-limiting step of microbial reduction. This is why DHB has significantly greater functional benefits compared to berberine. Supplementation with DHB mitigates potential GI distress that some experience with berberine, which is likely the result of poor absorption and/or microbial reduction.

    Features & Benefits

    The Benefits

    Versus berberine, DHB has shown to be up to 5x more bioavailable/absorbable, and 2x longer-lasting (8 hours vs. 4 hours)

    Improves insulin sensitivity and carbohydrate tolerance, supporting healthy blood glucose levels

    Supports body composition via AMPK, preferentially driving carbohydrates to muscle rather than fat

    Anti-aging support by reducing glycation end-products correlated with biological aging

    Ketogenic-friendly by increasing plasma BHB (ketones). Reduced GI distress compared to berberine due to DHB being the gut’s active metabolite.

    Our Advantage

    Highly bioavailable form of berberine (up to 5x more effective)

    More cost-effective alternative to berberine

    Less potential GI distress than berberine

    No Adulteration or Herbal Spiking (HPLC/HPTLC)

    Non-GMO and derived from natural berberine

    More Insulin Sensitivity, Glucose Disposal 

    Applications & Uses

    How To Use

    1 – 2 Servings per day (100 – 200 mg Per serving)

    Timing: prior to meals

    Topical application may have added benefits. 

    May have synergy when co-administered with probiotics, exogenous ketones, and/or MCTs (e.g. KetoVantage® & C8VantageTM). 

     

    Ways to use GlucoVantage:
    • Food
    • Beverages
    • Powder
    • Capsules

    Properties

    Regulatory & Compliance

    Technical Details & Test Data

    How It Works

     

    GlucoVantage® enhances insulin sensitivity effectively as well as inhibits adipocyte (fat cell) growth. Supports a healthy blood glucose level and insulin level.

    May have synergy with exogenous ketone or MCT administration (e.g. KetoVantage® or C8Vantage™).