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AlphaGOS® Probiome Booster

1 of 1 products in this brand
AlphaGOS® Probiome Booster is typical microbial colonies found on or in the body are normally benign or beneficial. These beneficial and appropriately sized microbial colonies carry out a series of helpful and necessary functions, such as aiding in digestion or protecting the body from the penetration of pathogenic microbes. These beneficial microbial colonies compete with each other for space and resources. When this balance is disturbed, due for example to antibiotic exposure, inappropriate diet, stress, etc., these colonies exhibit a decreased ability to check each other's growth, which can then lead to overgrowth of one or more of the disturbed colonies which may further damage some of the other smaller beneficial ones in a vicious cycle. This microbial imbalance is called “dysbiosis”. Metabolites produced in these conditions, such as LipoPolySaccharides (LPS) can thus damage the gut membrane and unable it to act properly as a barrier and lead to a so-called “leaky gut”.

Ingredient Name: Galacto-Oligosaccharide

Functions: Prebiotic

Labeling Claims: Dairy-free, Lactose-free, Non-GMO, Plant-Based

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    Knowde Enhanced TDS

    Identification & Functionality

    Ingredient Name

    Galacto-Oligosaccharide

    Food Ingredients Functions

    Prebiotic

    Pharma & Nutraceuticals Functions

    Prebiotic

    Ingredients
    Galacto-Oligosaccharide
    Technologies

    Food Ingredients,

    Pharmaceuticals & Nutraceuticals

    Product Families

    Pharmaceuticals & Nutraceuticals — Nutraceuticals & Supplements

    Prebiotics, Probiotics & Postbiotics

    Food Ingredients — Nutrition & Fortification

    Prebiotics, Probiotics & Postbiotics

    Food Ingredients — Whole Foods, Extracts & Premixes

    Plant & Herb Products & Extracts

    Features & Benefits

    Labeling Claims

    Dairy-free,

    Lactose-free,

    Non-GMO,

    Plant-Based

    Food Ingredients Features

    Promotes Digestive Health

    Benefits

    Bifidogenic (*)

    • Promotes the growth of bifidobacteria

    • Inhibits the adherence of pathogens

    Lactose- & Dairy-free 

    • Suitable for vegan and lactose intolerant people

    Plant-based 

    • Extracted from legumes
    • Non GM

    Very Pure

     

    • > 95% pure GOS
    • Gently processed

    (*) Potential consumer benefits have not been evaluated by EFSA nor FDA and are not to be considered as health claims. They should be considered as potential leads that might be developed into health claims complying with the local legal requirements

    Applications & Uses

    Markets

    Food & Nutrition

    Applications

    Food & Nutrition — Beverage

    Other Non-Alcoholic Beverages

    Food & Nutrition — Food

    Bakery,

    Confectionery,

    Infant & Baby Food

    Food & Nutrition Applications

    Confectionery Products,

    Infant Formula

    Application

    Gut Health and Probiotics culture

    Recommended dosage: 3g/day

    AlphaGOS® is perfectly soluble in water, tasteless and slightly sweet.

    Its flowability and granulometry enable to use it hard-gel capsules, sticks or sachets. It can also be used for orodispersible applications.

    Mode of Action

    The microbiota plays an active role in the integrity of the gut health membrane, through the production of various metabolites.

    While in a "dysbiotic" situation, the production of low-inflammation markers such as Lipo-PolySaccharides (LPS) may lead to an inflammation of the gut membrane cells, a disruption of tight junctions and finally, to an increased intestinal permeability - "leaky gut".

    Olygose AlphaGOS Probiome Booster Mode of Action

    Technical Details & Test Data

    GOS, gold-standard prebiotics

    Galacto-oligosaccharides (GOS) have been studied for decades for their effect on gastro-intestinal transit, on mineral absorption or on immunity and allergies, in particular throught their ability to promote the growth of bifidobacteria.

    Among the vast gut bacterial community, bifidobacterium is probably the most largely studied genus which colonizes Human gastro-intestinal tract at all life stages.

    While it is dominant in healthy breast-fed infants, its levels decrease but remain relatively stable in adulthood (30-40%) and then drop in elderly (10%) (Figure 1) (3). 

    The lack of bifidobacteria has been linked to a serie of diseases or conditions such as Irritable Bowel Syndrome (IBS), obesity, asthma, cystic fibrosis or allergies.

    Olygose AlphaGOS Probiome Booster GOS, gold-standard prebiotics

    Figure 1. Evolution of bifidobacteria levels throughout lifespan. Adapted from

    Proofs of efficacy

    The bifidogenic action of GOS has been studied in multiple preclinical and clinical trials in infants and adults and is now well established. 

    AlphaGOS® exerts prebiotic effects both in lean and obese subjects by increasing levels of bifidobacteria and modulating SCFAs production. These effects are similar to those of lactose-based GOS which are well-established prebiotics extensively studied in a variety of conditions.

    Olygose AlphaGOS Probiome Booster Proofs of efficacy - 1

    Figure 2. Comparison of bifidogenic effects of AlphaGOS and lactose-based GOS. Rows with a different letter are significantly different (p<0.001)

    Olygose AlphaGOS Probiome Booster Proofs of efficacy - 2

    Figure 3. Comparison of Short-Chain Fatty Acids production with AlphaGOS® and lactose-based GOS