Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Technologies
- Product Families
- Suggested Labeling
- Deep Sea Magnesium & Trace Elements, Magnesium & Trace Elements
- Deep Sea Minerals & Trace Elements, Minerals & Trace Elements
- Deep Sea Mineral Extract
Also contains balanced levels of Potassium, Sodium, Boron, Calcium and up to 75 Trace Elements in natural ionized free ion state.
Features & Benefits
- Benefit Claims
- Labeling Claims
- Deep Sea Magnesium, Minerals & Trace Elements
- Organic Process EU Protected Source Sustainable, 100% Natural & Pure
- Concentrated Liquid Water Based, 100% Bioavailable, 100% Bioactive Capacity
- Patented Technology Unique Free Ion Form Proven Health Benefits Clinical Science
- Deep Sea Magnesium, Minerals and Trace Elements balanced by ratio and volume acting at systemic and metabolic levels to deliver cellular, molecular and physiological functional benefits creating an environment that promotes cell health from within.
- Oriel Sustainable Economy
Our products come from sea water, through a system Patented across three continents. Fueled by steam, our steam creates our energy, our energy creates our products. We use our water with great care to create life changing solutions.
- Fresh Deep Seawater, a sustainable resource, pumped into Oriel plant
- Filtration, Separation & Concentration fueled by renewable energy sources
- Using 98% of the water we extract. To fuel our products and our boilers to make steam for evaporation
- Extracting unique form of Magnesium & Trace elements used in Medical, Skincare & Nutrition
- Re-using our wastewater and steam thru heat exchangers to reduce our energy usage
- Replacing ingredients in medical, skincare, health and nutrition which are NOT sustainable and with a higher carbon footprint
- Oriel operate within a Circular Economy of Sustainability of our Water, Energy, Product and Waste as we accelerate towards a Carbon Neutral Footprint
- Science Proven Health Benefits
- Supports Anti-Inflammatory Response
- Supports Cellular function and turnover
- Enhances Platelet Health & Function
- Enhances cardio function & circulation
- Moderates Gene Regulation and Expression
- Supports Healthy Stem Cell production (EPC)
- Supports Rapid Electrolyte replacement
Note: Stimulating Every Aspect Required for Beauty & Skin
Skin Health is all about Cell Health
Also contains balanced levels of Potassium, Sodium, Boron, Calcium, Chloride and up to 75 Trace elements in natural ionized free ion form as only found in living deep sea waters.
Applications & Uses
- Markets
- Treatment Product Applications
- Use Level
- 0.0003 - 0.5%
- Functions
- Liquid Magnesium, Minerals & Trace Elements as replacement or enhancement to current forms.
- Exceptional Bioavailability
- No Additives - No Taste Taint
- Synergistic enhancement of nutrient absorption
- High Impact Electrolyte Replacement
- Broad Range of Targeted Use
- Endurance & Energy levels
- Immune Function & Response
- Fatigue Recovery
- Muscle Repair & Recovery
- Injury Recovery
- Lower incidence of Cramp
- Topical Application
Harvested direct from the pristine deep sea water off Ireland’s coast through HydrasphereTM Technology, a Patented, Organic and Sustainable process that protects the free ion unbound state of the 100% Natural and Pure form of Magnesium and Minerals to deliver extraordinary bioavailability and bioactive response at a cellular level for Skin health and recovery.
Bioavailability: Skin health begins with cell health. Oriel enters the cells rapidly and efficiently ensuring its impact is acting intracellularly. This is achieved through rapid absorption directly through dermal layers and along the hair follicles.
Skin Barrier: When absorbed directly into the cells it creates a coalesce (relaxed & non-stressed) environment. Skin barrier function is improved from within with improved firmness, balance, cellular and skin health.
Hydration & pH: Improving Skin barrier function, creates an environment that promotes better hydration and pH with reduced Trans Epidermal Water Loss. Studies demonstrated 100% improved hydration in 24hrs
Anti-inflammatory Action: Specific studies demonstrated reduction of inflammatory biomarkers (98%) and of inflammatory micro-vesicles (92%) in 60mins. This has implications for multiple skin conditions and as a calming effect in skincare post exposure to stress, anxiety, allergy etc.
Cell Proliferation & Migration: Measured using xCELLigence DP Real-Time Cell Analyzer assessing cell motility and adhesion. Significantly improved migration, proliferation, adhesion and cell differentiation, resulting in improved cellular repair, regenerative capacity & skin health.
Molecular Regulation through Gene Expression
In a Gene specific study,
- Scarring & Immune: Key Genes implicated in skin immune function and scarring (FLG/PLG/IFNG/MMP9) were up-regulated with negative agonists (PTEN/IL8/IL4/WNT5A) down regulated.
- Insulin Growth Factor IGF-1: The longevity gene- Up-regulated by 76 fold in skin. Determines the impact of Chronological V biological age.
- Collagen: Additional Genes involved in production of Collagen and Skin Tissue formation were identified and up-regulated including:
- COL4A3 – 20 Fold – Production of Collagen Protein
- COL1A3 – 10 Fold – Provides instruction for making Type 1 Collagen
- COL3A3 – 6 Fold – Provides instruction for making Type 3 Collagen
- COL1A1, COL3A1, COL4A1, COL5A1, COL5A3 (ECM Producing Genes)
- Hyaluronic Acid Interaction: In studies, scientists demonstrated the efficacy and skin health benefits of HA to improve by up to 50% when combined with Oriel in terms of hydration, barrier and health.
Skin Health – Skin Cell Health – This is our Journey of Science.
- Skin barrier function is improved
- Skin hydration and pH are improved
- Collagen and Hyaluronic Acid – Upregulated and Improved Efficacy
- Regulation of Gene expression – The good goes Up the bad goes Down
- TEWL (Naturally via improved barrier function in cells)
- Skin cell repair and regeneration (via healthy Epithelial Stem Cells +88%)
- Reduced cellular inflammation through multiple skin layers.
- Improved skin health, condition, firmness, biomechanics and architecture.
- Ease of Formulation – Liquid water based – Cost effective at 0.33%
Note: Science proven on Dynamic 3D living human skin and on human dermal Fibroblasts, Keratinocytes and Endothelium cells.
- Proven Epigenetic Regulator
Up-regulated IGF-1 by 76-fold (the longevity gene) in skin.
8 critical genes necessary for Collagen production, Extra Cellular Matrix and Skin tissue formation up-regulated. Improved efficacy, up-regulation and production of Hyaluronic Acid
Deep Ocean Magnesium and Minerals acting at a cellular level to rapidly enter the cells via Free Ion bioavailability to promote skin health, repair and regenerate healthy cells for firmer, more radiant skin.
Contains each of the critical co-factor minerals to deliver efficient absorption direct to the cells. Water-soluble, and heat stable so can be added at any phase of formulation. A 100% Natural and Pure complex with no additives.
Liquid HydrasphereTM technology, protects Magnesium and Minerals in a free Ion form for rapid cell absorption and bioavailability.
- Skincare Synergy Nature Technology Science
- Deep Sea, Magnesium, Minerals & Trace Elements
- Up-Regulated Collagen & Hyaluronic Acid
- 100% Natural & Bioavailable
- Clinical cience Patented Technology
- Skin Hydration/TEWL/Barrier
- Hyaluronic Acid & Collagen Benefits
- Epigenetics
- Gene Expression and Regulation
- Fibroblasts/Keratinocytes
- Endothelium
- Dermal Microvasculature
- Platelets / Stems / Cardio
- Product Applications
- Multiple levels of filtration bring seawater to NTU of 0.5 prior to first stages of separation
- Pressurized crystalisation & removal of Calcium, Sulfate, Sodium, Chloride
- Evaporation of H2O until a unique ratio and balance of Minerals to Water is reached.
- Pressurized concentration, forces natural scientific fusion of H2O and Minerals. H2O forms Protective Sphere around Minerals
- Protective Sphere of H2O protects Minerals until absorption to cells causes sphere to safely fall away
Patented Process: USA, UK, EU, Aust, NZ, CA.
10,000 liters Sea Water per day- Recommended Uses
Skincare (0.25 – 0.33%) Anti-aging, moisturizers, face/body creams, gels, lotions, serums, baby care, post pregnancy skin firming. Sun burn aftercare, sunscreen. Cosmetics (0.25 – 0.33%) Foundation, mascara, concealer, make up. Atopic treatments (0.25 – 0.33%) Eczema, Psoriasis, cradle cap, dermatitis, allergy rash, dry skin Hair care (0.25 – 0.33%) Scalp, shampoo, thickener, conditioner, restoration, serum Sports Care (0.33 – 0.5%) Pre and Post Exercise / Muscle recovery / Joint relief Mineral Water (0.0003%) Mineralise your base water to transform it to a balanced Mineral water - Impacts of low Magnesium
- Metabolism of other Nutrients
- Muscular contraction & cramps
- ATP Production (Source of all energy)
- Muscle recovery during & post exercise
- Hydration during and post exercise
- Fatigue and Fatigue recovery
- Bone strength
- Transport of other Nutrients
- Getting to where it is needed
- Inflammatory response
- Magnesium - The Skin Health Mineral
Magnesiumplays a critical role in
- Activates more than 600 enzymatic processes
- Cell formation & health (skin, hair, nails, muscle…)
- 25% of our protein coding genes
- Multiple genes and biomarkers in skin health
- Energy metabolism(Production of ATP)
- Calciummetabolism(co-factor)
- Regulates Epigenetic processes (Inflammaging)
- RNA and DNA Synthesis
- Maintenance and electrical function of nerve tissues
- Maintenance & electrical function of cell membranes
Every cell in our body contains it and needs it to function properly with thousands of bio-chemical reactions reliant on it daily.
Approx: 60% in skeletal regions (bones, teeth, nails) 40% in muscles and soft tissues (skin, heart, brain) Less than 1% in extracellular fluid (Blood).
Our bodies cannot make Magnesium so as we age we tend to need it more fromother sources.
For skin, bioavailability, bio-functionality, form and source are critical. Oriel delivers – Science proven
- Haircare
- Weak Brittle Hair
- Follicle Roots
- Flaky Scalp
- Calcium build up
- Loss of Volume
- Follicle roots clogged Hair Thinning
- Hair breaking & loss
- Liquid Magnesium
- Rapidly Absorbed,
- Metabolizes Calcium
- Bioavailability
Novel source of nutrition to hair follicle root, hair follicles and scalp skin cells. Proven bioavailability, repair, healing and regeneration supported by anti-inflammatory and metabolic impacts. Key to achieving a real, measurable, improvement is Bioavailability. Deep Sea Magnesium, Minerals and Trace Elements proven by scientists in DCU to be the most bioavailable form are absorbed equally via dermal layers and hair follicle. A dual approach to follicle health and the prevention of calcium build up in the root.
Magnesium Studies demonstrate
- Improve hair thickness and volume
- Improve hair vitality and health.
- Reduce environmental impacts on hair and scalp
- Improve scalp condition
- Metabolic hormonal impact
- Improve dry and Itchy skin
- Reduce calcium build up in follicle root
- Improved barrier function – less ROS
- Combat and reverse conditions
- Platelet health & Circulation
Impacts of liquid Magnesium & Minerals on hair and scalp – You need to get to the ROOT
- Necessary for Protein Synthesis – Hair Follicles are +90% Protein
- Protein synthesis helps melanin (helps prevent hair going gray)
- Supports production of GABA & Dopamine levels which relax nervous system, promotes sleep and de-stressing which plays a major factor in the health of hair
- Metabolizes calcium to prevent build up (dry scalp, clogs hair follicles, thins hair)
- Supports Anti-Inflammatory response in the skin and scalp
- Responsible for +600 metabolic functions (including hair growth cycle & root health)
- Key role in enzymes for DNA repair and replication (Protection from free radicals)
- Benefits to Cardio function, platelet health, vasodilation, +oxygen, +barrier, -ROS.
- Magnesium, Selenium, Copper, Zinc, Sulfur, Phosphorous necessary for healthy hair
- Oralcare
Multiple clinical studies affirm the critical role of Magnesium in Oral Care and the health of Teeth and Gums. Why then, do we not start by enhancing an environment that promotes gum and teeth health from a cellular level. The key to efficacy and functionality is Bioavailability. Scientists in DCU have proven Oriel Deep Sea Magnesium Mineral Extract to have the most efficient bioavailability due to its unique form. Rapid, efficient and functional molecular effect. But it goes a lot deeper than this.
Collagen: The Gingival tissues are comprised of 60% collagen, the Periodontal ligament is 70-80% collagen while the alveolar bone matrix is 90% collagen. In clinical studies Oriel witnessed up-regulated, enhanced gene expression across multiple collagen biomarkers while simultaneously delivering a significant positive impact on multiple inflammatory and skin healing biomarkers.
The Collagen Snapshot – Up-regulated Genes
COL1A1: 14 Fold: Provides instruction for making Type 1 Collagen
COL3A1: 12 Fold: Provides instruction for making Type 3 Collagen
COL4A3: 20 Fold: Production of Collagen Protein
COL1A3, COL3A3, COL4A1, COL5A1, COL5A3 (Collagen ECM Producing Genes)Key Impacts of Magnesium on Teeth
- Critical Role in building strong Teeth & Enamel
- Co-Factor for Calcium: You cannot absorb or metabolize Calcium without Magnesium
- Necessary for Teeth/Enamel Structural health.
- Magnesium, Calcium & Phosphorus constitute the main structural components of teeth. (Each in Oriel)
- Supports and improves Periodontal Health
Key impacts and benefits of Oriel liquid Magnesium
- Improved cellular health, via rapid skin/gum absorption
- Up regulating of all key Collagen Biomarkers (repair to gums)
- Improved skin barrier and tensegrity (stronger healthier gums)
- Balance & metabolism of calcium (stronger teeth and enamel)
- Anti-Inflammatory – Promotes reduction of inflamed gums and bleeding
- Repair & Regeneration of circulating stem cells (improved gum health via platelet health)
- Anti-bacterial impacts of Oriel Magnesium on wound healing.
- Multiple published studies on benefits.
- Opportunities in Toothpaste, Mouthwash, Gum Gels, Teeth and enamel strength, Gum health, the Silver Market.
Properties
- Physical Form
- Taste
- Salty
- Odor
- Odor free
- Flavor
- Intense magnesium mineral
- Soluble in
- Water
- Stable in
- Heat
- Dilution
- 300/1 – 3000/1 (Depending on application and desired results)
- Bioavailability at Every Level is the Key
Bioavailability and absorption can only make a difference if it gets to where it is needed quickly and efficiently to become intracellular in a form rapidly metabolized by the body to the cells.
Hydrasphere Patented technology creates an environment of Free Ions, unbound and rapidly absorbed.
We demonstrate Free Ion Bioavailability through functionality at every level.
- Unique unbound Liquid Free Ion form
- Co-Factor Minerals & Trace Elements
- Balance of Minerals & Trace Elements
- Ratio of Minerals & Trace Elements
Regulatory & Compliance
Technical Details & Test Data
- Research Studies Demonstrate Improved
- Blood Platelet Health – Dermal microvasculature
- Up Regulation of Collagen Biomarkers (1,2,3,4,5)
- Gene Expression of Collagen Protein Genes
- Efficacy and Synthesis of Hyaluronic Acid
- Production of body’s natural Collagen
- Production of body’s natural Hyaluronic Acid
- IGF-1 Longevity Gene – Up-regulated 76 Fold
- Cardiovascular Function 24% in 24Hrs
- Skin Barrier, Hydration, Ph, Volatile Release, TEWL
Additional key impacts on Beauty from Within
- Increases GABA & Regulates Melatonin to improve relaxation, sleep and natural circadian rhythms.
- During Sleep, we Heal, Recover, Replenish & Rejuvenate
- Relaxes neurons directly related to Anxiety & Stress
- Mitigate & Reverse impact of high calcium on cells
- Test Data
De-clogging of a hair follicle root via magnesium intervention Hair Follicles significantly contribute to magnesium permeation.
A. Plugged skin (plugged region shown in blue.
B. Unplugged skin sections allow penetration of Mg ions
C. Increased penetration of Mg ions in unplugged skin
- Powerful Published Science
- Supports Anti-Inflammatory Response
- Supports Cellular function and turnover
- Enhances Platelet Health & Function
- Enhances cardio function & circulation
- Moderates Gene Regulation and Expression
- Supports Healthy Stem Cell production (EPC)
- Supports Rapid Electrolyte replacement
- How will liquid Magnesium & Minerals help?
- Magnesium is essential for calcium & oxygen transport to cells
- Critical role in extended endurance activity through enzyme reaction
- Glycolysis uses 10 enzymes which require magnesium to make ATP
- Enhances Cardiovascular Function and blood platelet health
- Necessary along with Sodium & Potassium (each balanced in Oriel)
- Brings balance to cells through metabolizing calcium
- Bones need Calcium BUT Calcium needs Magnesium to be metabolized
- Supports metabolization of vitamin D, vitamin B and calcium
- Metabolic Mineral - Your body uses it where it needs it most.
- Directly supports Inflammatory response (+ / -)
Packaging & Availability
- Pack Size
1 liter / 20 liter
Storage & Handling
- Shelf Life
- 48 Months
- Storage
Ambient Temp 15 - 20 °C