Pharm-Rx Docetaxel Trihydrate USP

Identification & Functionality

Chemical Name

Docetaxel Trihydrate

Molecular formula

C₄₃H₅₃NO₁₄ · ₃H₂O

Technologies

Pharmaceuticals & Nutraceuticals

Product Families

Pharmaceuticals & Nutraceuticals — Pharmaceutical Actives & Precursors

Active Pharmaceutical Ingredients (APIs)

Chemical Structure

Defination

(C₄₃H₅₃NO₁₄), calculated on the anhydrous and solvent-free basis. [CAUTION—Docetaxel is cytotoxic. Great care should be taken to prevent inhaling particles of Docetaxel and exposing the skin to it.]

Applications & Uses

Markets

Healthcare & Pharma

Applications

Healthcare & Pharma — Drug Delivery & Care Solutions

Other Drug & Care Solutions

Properties

Typical Properties

	Value	Units	Test Method / Conditions
Molecular Weight	861.93	—	—

Regulatory & Compliance

Certifications & Compliance

United States Pharmacopeia (USP)

USP Reference Standards

• USP Docetaxel RS
• USP Docetaxel Identification RS
• It contains docetaxel and small amounts of the following: 2-Debenzoxyl 2-pentenoyl docetaxel: (2aR,4S,4aS,6R, 9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a, 12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a, 8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4] benz[1,2-b]oxet-5-one 12b-acetate, 12-[(E)-2- methylbut-2-enoate], 9-ester with (2R,3S)-N-tert- butoxycarbonyl-3-phenylisoserine. C₄₁H₅₅NO₁₄ 785.87
• 6-Oxodocetaxel: (2aR,4S,4aS,9S,11S,12S,12aR,12bS)- 1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4, 9,11,12,12b-pentahydroxy-4a,8,13,13-tetramethyl- 7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5,6- dione 12b-acetate, 12-benzoate, 9-ester with (2R,3S)- N-tert-butoxycarbonyl-3-phenylisoserine. C₄₃H₅₁NO₁₄ 805.86
• 4-Epidocetaxel: (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)- 1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro- 4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl- 7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5- one 12b-acetate, 12-benzoate, 9-ester with (2R,3S)-N- tert-butoxycarbonyl-3-phenylisoserine. C₄₃H₅₃NO₁₄ 807.88
• 4-Epi-6-oxodocetaxel: (2aR,4R,4aS,9S,11S,12S,12aR, 12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b- Dodecahydro-4, 9,11,12,12b-pentahydroxy-4a, 8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4] benz[1,2-b]oxet-5,6-dione 12b-acetate, 12-benzoate, 9-ester with (2R,3S)-N-tert-butoxycarbonyl-3- phenylisoserine. C₄₃H₅₁NO₁₄ 805.86
• USP Docetaxel System Suitability Mixture RS Contains docetaxel and a small amount of 6-oxodocetaxel, O-BOC N-pyruvyl docetaxel, 4-epidocetaxel, and 4-epi- 6-oxodocetaxel.

Storage & Handling

Storage Information

Preserve in well-closed, light-resistant containers, and store at room temperature or between 2° and 8°.