Pharm-Rx - Paroxetine HCL Hemihydrate - 110429-35-1

Knowde Enhanced TDS

Identification & Functionality

Chemical Name: Paroxetine Hydrochloride Hemihydrate
Molecular formula: C₁₉H₂₀FNO₃ · HCl, C₁₉H₂₀FNO₃ · HCl · ½H₂O
Technologies: Pharmaceuticals & Nutraceuticals
Product Families: Pharmaceuticals & Nutraceuticals — Pharmaceutical Actives & Precursors
Active Pharmaceutical Ingredients (APIs)
Chemical Structure
Definition: Paroxetine Hydrochloride is anhydrous or contains one-half molecule of water of hydration. It contains NLT 98.5% and NMT 102.0% of paroxetine hydrochloride (C₁₉H₂₀FNO₃ · HCl), calculated on the anhydrous and solvent-free basis.

Applications & Uses

Markets: Healthcare & Pharma
Applications: Healthcare & Pharma — Drug Delivery & Care Solutions
Other Drug & Care Solutions

Properties

Typical Properties

	Value	Units	Test Method / Conditions
Molecular Weight	365.83	—	—
Molecular Weight	374.83	—	—

Regulatory & Compliance

USP Reference Standards: USP Paroxetine Hydrochloride RS
USP Paroxetine Related Compound B RS(3S,4R)-3-[(Benzodioxol-5-yloxy)methyl]-4-phenylpiperidine hydrochloride.
C₁₉H₂₁NO₃· HCl 347.84
USP Paroxetine Related Compound C RS(3R,4S)-3-[(Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride;Also known as (+)-trans-Paroxetine hydrochloride.
C₁₉H₂₀FNO₃· HCl 365.83
USP Paroxetine Related Compound E RS4-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridinehydrochloride.
C₁₂H₁₄FN · HCl 227.71
[NOTE—Paroxetine related compound E was previous identified as 1-methyl-4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride.]

USP Paroxetine Related Compound F RS (3S,4R)-3-[(Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine.
C₂₀H₂₂FNO₃ 343.39

USP Paroxetine Related Compound G RS (3SR,4RS)-3-[(Benzodioxol-5-yloxy)methyl]-4-(4′-fluorobiphenyl-4-yl)piperidine hydrochloride;Also known as(±)trans-3-[(1,3-Benzodioxol-5-yloxy) methyl]-4-(4′′-fluorophenyl-4′-phenyl)piperidine hydrochloride.
C₂₅H₂₄FNO₃· HCl 441.93

USP Paroxetine System Suitability Mixture A RS
Contains a mixture of the following three compounds: Paroxetine hydrochloride. Paroxetine related compound A: (3S,4R)-3- [(Benzodioxol-5-yloxy)methyl]-4-(4-methoxyphenyl)piperidine hydrochloride; Also known as piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-methoxyphenyl)-, hydrochloride (3S-trans)-.

C₂₀H₂₃NO₄∙HCl 377.86

Paroxetine related compound B: (3S,4R)-3-[(Benzodioxol-5-yloxy)methyl]-4-phenylpiperidine hydrochloride;

Also known as piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-phenyl-,hydrochloride (3S-trans)-.
C₁₉H₂₁NO₃∙HCl 347.84

Pharm-Rx Paroxetine HCL Hemihydrate

Knowde Enhanced TDS