Pharm-Rx Tacrolimus

Identification & Functionality

Chemical Name

Tacrolimus

Molecular formula

C₄₄H₆₉NO₁₂ · H₂O

Technologies

Pharmaceuticals & Nutraceuticals

Product Families

Pharmaceuticals & Nutraceuticals — Pharmaceutical Actives & Precursors

Active Pharmaceutical Ingredients (APIs)

Chemical Structure

Definition

Tacrolimus contains NLT 98.0% and NMT 102.0% of tacrolimus (C₄₄H₆₉NO₁₂), calculated on the anhydrous and solvent-free basis.

Applications & Uses

Markets

Healthcare & Pharma

Applications

Healthcare & Pharma — Drug Delivery & Care Solutions

Other Drug & Care Solutions

Properties

Typical Properties

	Value	Units	Test Method / Conditions
Molecular Weight	822.03	—	—

Regulatory & Compliance

USP Reference Standards

USP Tacrolimus Related Compound A RS(E)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(E)-2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21-(4H,23H)-tetrone.
C₄₃H₆₉NO₁₂ 792.02(ERR 1-Sep-2021)
USP Tacrolimus 8-epimer RS(3S,4R,5S,8S,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Allyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone.
C₄₄H₆₉NO₁₂ 804.03 (ERR 1-Sep-2021)
USP Tacrolimus 8-propyl Analog RS(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-8-propyl-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone.
C₄₃H₆₉NO₁₂ 792.01 and tacrolimus 8-propyl analog (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R, 19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24, 25,26,26a-Hexadecahydro-5,19-dihydroxy-3-{(E)-2- [(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-8-propyl-3H-pyrido[2,1-c][1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone.
C₄₄H₇₁NO₁₂ 806.03

Storage & Handling

Storage Information

Preserve in tight containers. Store at controlled room temperature.