Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Ingredient Name
- Country of Origin
- Spain
- Ingredients
- Olive Extract
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Product Highlights
- Controlled process and traceability.
- Natural immune booster, with microbicidal and immunomodulatory effect
- Traditional ingredient that appeals to consumers as natural, effective and safe solution
- Unique olive leaf extract with double standardization: 20% oleuropein + 2% bioflavonoids by HPLC.
- Improved stability due to strong antioxidant capacity.
- Multi-target mechanism of action.
- Locally-sourced. Environmentally responsible.
- Olivactive® is locally sourced from olive trees grown in fields in the Mediterranean and uses an extraction process that is fully controlled and completely traceable, leveraging ancestral know-how in order to provide a final extract of the highest quality and purity.
- Benefits of Olivactive®
- Natural immune booster.
- Traditional roots that appeal to consumers as natural, effective, and safe solution.
- Unique olive-leaf extract with double standardization.
- Multi-target mechanism of action.
- Locally sourced. Environmentally responsible.
Applications & Uses
- Markets
- Use Level
- 300 mg/day (Maintainance RDD), 500 mg/day (Intensive RDD)
- Mechanisms of Action
Olivactive® and its bioactive compounds have shown three main mechanisms of action:
- Macrophage and granulocytes stimulation to initiate a proinflammatory pathway to help combat pathogens*.
- Oleuropein breaks down hydroxytyrosol during the digestion, which may promote bacteria cell walls breaking, and cellular membrane damaging*.
- Olivactive® may attenuate the overall inflammatory state*, reducing inflammation in several cell types.
- Olivactive® may as well have a positive effect on glycemia regulation*, thanks to the modulation of the activity of several enzymes.
- Application of Olives
- Traditionally used to lower fever
- The olive tree has been cultivated throughout the Mediterranean basin for centuries.
- The use of olive leaves for medicinal purposes dates back to Ancient Egypt, where it was used as a popular remedy to combat fever.
- Olive is familiar to a wide range of population worldwide.
- Immune-boosting botanicals that come from ancient or traditional medicine, appeal to consumers, who perceive them as natural, effective and safe.
Properties
- Solubility
- Soluble in
- Water
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Bioflavonoids | min. 2 | % | HPLC. |
| Oleuropein | min. 20 | % | HPLC |
Regulatory & Compliance
Technical Details & Test Data
- Olivactive® Immunomodulatory Activity
The oleuropein present in Olivactive® regulates the immune response of macrophages and granulocytes by controlling:
- · The release of Nitric Oxide (NO) and Reactive Oxygen Spices (ROS) that exert an antimicrobial effect
- · The expression of inflammatory mediators that promote adaptative immune response (such as TNF-a, IL-6, or COX-2)).
- Olivactive® Anti Microbial Activity
- The oleuropein present in Olivactive® has shown strong antimicrobial activity against bacteria (Gram-negative and Gram-positive), mycoplasma and viruses. Moreover, it seems to be especially useful in antibiotic-resistant infections.
- The oleuropein breaks down into hydroxytyrosol, which promotes the breakage of bacteria cell walls, and damages cellular membranes (via the action of ortho-diphenols).
- Olivactive® Activity as Systemic Anti Inflammatory
- Bioflavonoids and oleuropein present in Olivactive® attenuate the overall inflammatory state, reducing inflammation in several cell types, including muscle and lung cells. Bioflavonoids regulate the expression of inflammatory mediators, such as TNF-a, IL-613 and IL-4.
- Olivactive® Glycemia Balance Activity
- The bioflavonoids present in Olivactive® inhibit two enzymes involved in glucose absorption in the gastrointestinal tract (a-amylase and a-glucosidase) leading to a positive effect on immune system strength.
- The oleuropein present in Olivactive® has shown to regulate glycemia through NOX2 (NADPH Oxidase 2) gene expression modulation (which is overexpressed in these cases), contributing to a reduction in the generation of metabolic oxidative stress.
Numerous scientific publications have related pathological glycemia (characterized by high levels of glucose in the blood] with increased frequency of infections and decreased ability to fight them.
Some of the consequences of unbalanced glucose levels are:
- Defective leucocyte performance.
- Reduced capacity for leucocytes to phagocytize and effectively kill bacteria.
- Less ability for Immunoglobulin G to recognize bacteria.
Packaging & Availability
- Minimum Order Quantity
25 Kg
Storage & Handling
- Shelf Life
- 2 years