Knowde Enhanced TDS
Identification & Functionality
- Carrier
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Country of Origin
- Italy
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Features
- L. rhamnosus LRH020 probiotic-derived
- Help avoiding pathogens colonization
- Skin surface strengthening for better resistance vs. environmental stresses
- Promotion of natural skin defenses
- “Prebiotic” effect: nourishment and support for resident microbiota growth
- Enhancement of skin healthy barrier and hydration
Applications & Uses
- Markets
- Applications
- Use Level
- 0.01
Properties
- Typical Properties
- Composition
- Properties
- EquiBiotics® LRh is the new tyndalized active ingredient developed by Roelmi HPC.
- It contains a minimum of 10Billion/gram of L. Rhamnosus cells (Strain code: LRH020 – collection number: LMG P-29513/DSM 25568).
| Value | Units | Test Method / Conditions | |
| Average Particle Size (D50) | 3 - 7 | µm | — |
| Value | Units | Test Method / Conditions | |
| Maltodextrin | min. 75 | % | — |
| Lactobacillus | max. 1 | % | — |
Regulatory & Compliance
Technical Details & Test Data
- Manufacturing Flow Chart
- In-Vitro Efficacy Dossier: Modulation of Inflammatory Status
- Evaluation of the anti-inflammatory activity in cell cultures (human keratinocytes), in presence of an inflammation agent (SDS 0.05 mg/ml).
- Compared to alive probiotics, EquiBiotics® LRh comparably modulates the release of TNF-α.
- Biomimetic behavior
- Cellular defense
* p<0.05 vs CTR-, ° p<0.05 vs CTR+
- In-Vitro Efficacy Dossier: Prevention of Pathogens Colonization
- Evaluation of the bacteriostatic activity on C. acnes, identified as etiological agent responsible for cutaneous distresses, like acne.
- EquiBiotics® LRh, at different dosages %, shows a modulation of pathogen growth.
- Skin microbiota equilibrium
- Co-aggregation mechanism
- In-Vivo Efficacy Dossier: Reduction of SLS-Induced Redness
- Evaluation of the capability in reducing skin sensitization after chemical stress.
- After 14 days, 1% EquiBiotics® LRh cream resulted statistically significant and effective in decreasing the SLS-induced skin erythema by -17.0%.
- Skin recovery
- Skin barrier strengthening
Protocol: placebo-controlled study carried out on 20 female subjects. The study duration is 14 days and products efficacy in decreasing the SLS (Sodium Lauryl Sulfate)-induced skin redness is assessed by means of instrumental evaluation of skin redness (a* parameter) and evaluated before and after 14 days of product use. Material: colorimeter CM-700D (Konica Minolta). Results are reported as variation % vs. untreated skin (T0).
Storage & Handling
- Shelf Life
- 24 Months
- Storage Conditions
Keep the product in the original container, well closed, in a cool and dry place (15- 30°C), protected from humidity, light or heat sources.