Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Highlights
- Invigorating blast to the senses with activation MS ME burst releases menthol when exposed to moisture. However, the continuous release is modulated by the level of water at the proximate environment.
- Cost effective and safe production by reduced vapors MS ME reduces the initial menthol odor and allows production at higher temperatures that reduce menthol loss.
- Longer Shelf Life: Encapsulation reduces evaporation of menthol, leaving more menthol for the user
- Product Background
Menthol has analgesic properties that are mediated through a selective activation of k-opioid receptors. It also provides a cooling sensation by chemically triggering the cold-sensitive TRPM8 receptors in the skin. As a result of these properties, menthol is commonly used in various pain relief, skin care, lip care, and oral applications.
The challenge of formulating with menthol is that, though they are solid crystals at room temperature, they evaporate just above that temperature point, leading to significant loss of cooling sensation in final products. Additionally, menthol has a natural, medicinal odor that may be undesirable for certain applications.
- Product Information
MultiSal™ Menthol reduces the menthol odor and stabilizes and protects it from evaporation, even under elevated temperatures (up to 160˚ C).
MultiSal™ Menthol is a double encapsulation delivery system infused with menthol. The menthol is first encased in sub-micron spheres, approximately 0.1 to 0.3 microns in diameter, then encapsulated again within an outer microsphere shell that is about 30 microns in diameter. The extra protection results in a less intense menthol odor and maintains the menthol in its potent form. The system is activated by water, at which point the outer microsphere will break down and release the sub-micron spheres. These smaller spheres will then slowly release the menthol to provide a long-lasting cooling sensation.
The structure of MultiSal™ Menthol, a microsphere composed of water-triggered release properties and infused with sub-micron spheres containing menthol.
Applications & Uses
- Markets
- AP/Deo Applications
- Bath & Shower Applications
- Color Cosmetic Applications
- Skin Care Applications
Properties
- Typical Properties
| Value | Units | Test Method / Conditions | |
| pH (1% Solution) | 3 - 5 | - | - |
| Dosage (Lip) | 0.2 | kg/kg | |
| Dosage (Skin) | 0.4-1.0 | kg/kg | |
| Dosage (Pain) | 0.8-1.6 | kg/kg | |
| Dosage (Foot) | 1.4-4.0 | kg/kg |
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Efficacy Tests
Thermal Gravimetric Analysis
The MultiSal™ technology protects menthol at temperatures of up to 160˚ C (Figure 2, next page). Thermal Gravimetric Analysis (TGA) was utilized to measure the retention of menthol over a range of temperatures. MultiSal™ Menthol demonstrates greater thermal stability compared to free menthol, losing only 6% of its initial mass at 160˚ C. Without the protection of the technology, free menthol begins to break down at just 80˚ C, with complete loss occurring at 130˚ C.
The amount of menthol retained at varying temperatures up to 160˚ C from MultiSal™ Menthol and free menthol. Data was measured by Thermal Gravimetric Analysis (TGA).
Long Lasting Cooling Sensation
The cooling sensation from MultiSal™ Menthol was compared to that of free menthol from a body powder application . Five volunteers applied 0.3 grams of each sample to their forearms. After misting water onto the areas, cooling intensity was measured on a scale of zero to five, with five being the most intense cooling sensation.
Cooling intensity evaluated by a panel of volunteers after applying a body powder containing MultiSal™ Menthol and free menthol loaded at 0.8%.
MultiSal™ Menthol shows significant and consistently higher performance in terms of extending the cooling benefits of menthol over time.
Water-Triggered Release
The outer shell of MultiSal™ Menthol breaks down to release its contents when triggered with water. The effect of water on menthol odor intensity was evaluated in an anhydrous deodorant stick application on a scale of zero to five, with five being the most intense odor.
Odor intensity from a deodorant stick containing MultiSal™ Menthol and a deodorant stick containing free menthol once activated by water.
The deodorant stick containing free menthol exhibits similar odor intensity in both dry and wet conditions, indicating that the moisture trigger has little effect. The deodorant stick containing MultiSal™ Menthol, however, results in a significantly higher menthol odor burst after it is activated by water. This shows that the double encapsulation system is able to keep the menthol virtually odorless until its release is required.
Storage & Handling
- Storage and Handling
Closed container at 12-32° with <45% RH