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Identification & Functionality
- INCI Name
- Cosmetic Ingredients Functions
- Technologies
Features & Benefits
- Product Information
SalSphere™ Severe Acne Relief is an advanced technology that delivers salicylic acid (SA) and other functional ingredients to fight the various signs and causes of the more severe cases of acne. This comprehensive formula is the last resort topical solution before seeking treatment by a dermatologist.
In typical skincare formulations, it is challenging to formulate with functional ingredients that require different pH levels for optimal activity in a single product. SalSphere® technology keeps the ingredients from counteracting one another and maximizes efficacy.
SalSphere™ Severe Acne Relief is a sub-micron sphere delivery system ranging from 0.1 to 0.3 microns in diameter. The sphere consists of a polymer shell that enhances adhesion to lipids, such as comedones, to facilitate targeted treatment where it is needed most. The core is made up of lipophilic ingredients that modulate the release of the multiple functional ingredients as the system partitions into the skin. The slow release mechanism of SalSphere™ technology facilitates skin-friendly treatment by delivering smaller “dosages” of functional ingredients over time.
Functional Ingredients
Acne is the most common skin disorder, affecting 40 to 50 million people in the United States alone. More than 40% of teens suffer from acne and acne scarring, and the condition can also develop during adulthood. Billions of dollars are spent each year for the treatment of acne, including the costs for prescription products.
SalSphere™ Severe Acne Relief provides multiple benefits to the skin including powerful, yet skin-friendly exfoliation, reduction of excess sebum, and antimicrobial, anti-inflammatory, and skin reparative activity. The technology is designed to provide an alternative treatment prior to the use of expensive prescription medications and their accompanying side effects.
- Product Highlights
- ALL-IN-ONE SOLUTION Single system addresses multiple cause of acne. Delivers optimal exfoliation, controls sebum, reduces scars and blemishes, and moisturizes skin.
- EASY TO FORMULATE WITH One system contains all the required ingredients.
- COST EFFECTIVE Reduces time spent on formulation, purchasing, and managing inventory of multiple ingredients.
Applications & Uses
- Markets
- Skin Care Applications
- Treatment Product Applications
Properties
- Odor
- Characteristic
- Appearance
- Translucent Liquid
- Miscible In
- Water
Technical Details & Test Data
- Efficacy Tests
Sebum Control without Drying
SS SAR reduces sebum from oily skin without causing dryness. SS SAR reduced sebum nearly to the ideal level, as contrasted to the free ingredients.
Figure: Oil level of SS SAR vs free components during in-vivo study (n=3). Levels taken using Hydr8 Digital Skin Analysis System (Epicureanist, LLC).
Skin Moisture Content
Figure: Moisture content of SS SAR vs free during in-vivo study (n=3). Levels taken using Hydr8 Digital Skin Analysis System (Epicureanist, LLC).
Improved Retention on Skin
When used in a wash, SS SAR deposits almost 10 times more salicylic acid onto skin.
Figure: Salicylic acid remaining on skin postrinse after treatment with a 2% SA (wt%) facewash formulation during in-vivo study (n=3).
Targeted Treatment
SalSphere™ Severe Acne Relief demonstrates enhanced penetration compared to the free form of salicylic acid. In a clinical study (n=6), SalSphere™ Severe Acne Relief in a lotion and free salicylic acid in a lotion were applied to the forearms of volunteers. Ethanol extractions were performed over a period of six hours and analyzed by HPLC.
Figure: Amount of salicylic acid detected on skin from a lotion containing SalSphere™ Severe Acne Relief and a lotion containing free salicylic acid.
SalSphere™ Severe Acne Relief is better able to maintain salicylic acid on the skin for a period of six hours. The delivery system makes functional ingredients available on the skin for a longer period of time to enhance treatment benefits.
Skin- Friendly
SalSphere™ Severe Acne Relief delivers a powerful complex of acne-fighting ingredients in a slow release manner in order to maintain a skin-friendly pH in the range of 4.5 to 5.5. A study was done comparing SalSphere™ Severe Acne Relief in a face wash to free salicylic acid in a face wash (Figure 3). Volunteers (n=6) washed allocated areas with each application. Skin pH was measured using the Hanna® HI 99181 pH meter over four hours.
Figure: Skin pH of allocated areas after using a face wash containing SalSphere™ Acne Relief and a face wash containing free salicylic acid.
The area on the skin treated with SalSphere™ Severe Acne Relief maintains a skin-friendly pH throughout the four hours. The area treated with free salicylic acid, however, experiences a drop in pH below 4.0 at application. This low level of pH is conducive to skin irritation, a side effect that will further disturb the acne problem being treated in the first place. By four hours, the skin treated with free salicylic acid fails to re-balance itself and remains outside the skin-friendly pH range.
Storage & Handling
- Shelf Life
- 36 months
- Storage and Handling
Closed container at 12-32°C