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HPMCP
Shin-Etsu Pharma, Nutra and Food Brand
Supplier:Shin-Etsu Pharma, Nutra and Food
Products:3
An enteric coating agent is used to protect drugs from degradation by gastric acid or to protect gastric mucosa from irritating drugs. HPMCP (Hypromellose Phthalate), since its introduction into the market in 1971 as an alternative cellulose derivative for enteric coating, has been demonstrated to be an effective and safe material by many researchers and is widely used as an enteric coating agent by the pharmaceutical industry. HPMCP has been admitted into the U.S. National Formulary (USP/NF), European Pharmacopeia (EP), and Japanese Pharmacopeia (JP).
The chemical structure of HPMCP is a monophthalic acid ester of Hypromellose (hydroxypropyl methylcellulose), and the threshold pH value for rapid disintegration of HPMCP can be controlled by varying the phthalyl content. Two types of HPMCP with different in pH-solubilities, HP-55 and HP-50, are available. Moreover, HP-55S, a special type of HP-55, which is distinguished by its higher molecular weight, greater film strength and higher acid resistance properties, has also been introduced. A suitable grade of HPMCP for a particular purpose should be selected in accordance with each preparation.
Knowde Brand Highlights
- Brand Highlights
- Suitable for solvent coating system. As co-solvents, mixture of ethanol and water (80/20 w/w%) or mixture of acetone and water (95/5 w/w%) are recommendable.
- Relatively stable, due to less hydrolysis.
- Available as a solid dispersion carrier for solubility enhancement.