Knowde Enhanced TDS
Identification & Functionality
- Chemical Name
- Pharma & Nutraceuticals Functions
- CAS No.
- 71138-97-1
- EC No.
- 615-255-9
- Technologies
Features & Benefits
- Labeling Claims
- Features
- For enteric coating, various coating methods can be applied such as aqueous, organic solvent, ammonia neutralized and dry coating. Coating methods can be selected depending on the characteristic of API. For example, dry coating is suitable for water and solvent sensitive API.
- Shin-Etsu AQOAT® is also used in solid dispersion for solubility and bioavailability enhancement. In order to prepare solid dispersion, various methods are applicable such as spray dry, spray coating, hot melt extrusion (HME), coprecipitation etc. As Shin-Etsu AQOAT® can dissolve into various organic solvents and has relatively low glass transition temperature (Tg), it is one of the most suitable polymers in solid dispersion. Numerous scientific papers reported that Shin-Etsu AQOAT® was able to enhance the drug solubility more effectively compared to other polymers.
Applications & Uses
- Markets
- Applications
Properties
- Typical Properties
- Particle
- Fine**
- Note
*Viscosity of 2 w/w% solution of sodium hydroxide aqueous solution at 20oC
**D 50: NMT10 μm, D 90: NMT20 μm by laser diffraction method
***D 50: 70 - 300 μm by laser diffraction method
Abbreviation; HPMCAS
| Value | Units | Test Method / Conditions | |
| Acetyl Content | 10.0 - 14.0 | % | — |
| Hydroxypropoxy Content | 6.0 - 10.0 | % | — |
| Methoxy Content | 22.0 - 26.0 | % | — |
| pH Solubility | min. 6.5 | — | — |
| Succinoyl Content | 4.0 - 8.0 | % | — |
| Viscosity | 2.4 - 3.6 | mPas | — |
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
- Grade
Packaging & Availability