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TYLOPUR® 606

Sold by Shin-Etsu Pharma, Nutra and Food
Chemical Name: Hypromellose
Function: Thickener, Binder, Coating System, Viscosity Modifier, Taste Masker
CAS Number: 9004-65-3
Dosage Form: Tablets, Pellets, Orally Disintegrating Films (ODFs)
Labeling Claims: Plant-Based, Kosher, Allergen-free, Non-GMO, Halal
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Alysia McleodPlease reach out to me with any questions, I am happy to assist you in finding the right product or learning more about our storefront.
Please reach out to me with any questions, I am happy to assist you in finding the right product or learning more about our storefront.

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Identification & Functionality

TYLOPUR® 606 Features & Benefits

Applications & Uses

Properties

Physical Form
Typical Properties
ValueUnitsTest Method / Conditions
Bulk Density (Fluid Bed 1% Tylopur 606)0.41g/cm3-
Bulk Density (Fluid Bed 4% Tylopur 606)0.3g/cm3-
Heavy Metalsmax. 20ppmEP
Hydroxypropoxy Content7.0 - 12.0%EP
Loss on Dryingmax. 5.0%-
Loss on Drying (Fluid Bed 1% Tylopur 606)0.5%-
Loss on Drying (Fluid Bed 4% Tylopur 606)1.1%-
Methoxy Content28.0 - 30.0%-
pH5.0 - 8.0-EP
Sulphated Ash /Residue On Ignitionmax. 1.5%EP
Visocity4.8 - 7.2mPas-
Coating Properties
ValueUnitsTest Method / Conditions
Inlet Air Flow (Coating Parameters)Constantm3/h-
Inlet Air Flow (Coating Parameters)400.0m3/h-
Inlet Air Temperature (Coating Parameters)80.0⁰C-
Nozzle Pressure Bar (Coating Parameters)0.65bar-
Nozzle Pressure Bar (Coating Parameters)2.9bar-
Pan Speed (Coating Parameters)22.0rpm-
Pan Speed (Coating Parameters)11.0rpm-
Spray Rate (Coating Parameters)4.3 - 6.1g/minEP
Spray Rate (Coating Parameters)9 - 23g/minEP
Tablet Bed Temperature during Coating38 - 40⁰C-
Tablet Bed Temperature during Coating35 - 40⁰C-
Tablet Bed Temperature during Coating40.0⁰C-
Processing Parameters
ValueUnitsTest Method / Conditions
Air Flow (Granulation Parameters for 4% Tylopur 606)40.0m3/h-
Air Flow(Granulation Parameters for 1% Tylopur 606)40.0m3/h-
Angle of Response (Fluid Bed 1% Tylopur 606)46.4-
Angle of Response (Fluid Bed 4% Tylopur 606)44.4-
Bowl (Granulation Parameters for 4% Tylopur 606)3.0L-
Bowl (Granulation Parameters for1% Tylopur 606)3.0L-
Disintegration Time728.0S-
Dissolution(>80%) min10.0-EP
Filter Cleaning / pause (Granulation Parameters for 1% Tylopur 606)5 / 0.5SEP
Filter Cleaning / pause (Granulation Parameters for 4% Tylopur 606)5 / 0.5SEP
Filter Pressure (Granulation Parameters for 1% Tylopur 606)1.5 - 2.0barEP
Filter Pressure (Granulation Parameters for 4% Tylopur 606)1.5 - 2.0barEP
Inlet Air Temperature (Granulation Parameters for 1% Tylopur 606)65.0⁰C-
Inlet Air Temperature (Granulation Parameters for 4% Tylopur 606)65.0⁰C-
Nozzle Position / Pressure (Granulation Parameters for 1% Tylopur 606)1.2mm / 1.5 bar--
Nozzle Position / Pressure (Granulation Parameters for 1% Tylopur 606)1.2/ 1.5mm / bar-
Nozzle Position / Pressure (Granulation Parameters for 4% Tylopur 606)1.2mm / 1.5 bar--
Nozzle Position / Pressure (Granulation Parameters for 4% Tylopur 606)1.2/ 1.5mm / bar-
Process time - Drying (Granulation Parameters for 1% Tylopur 606)8.0minutes-
Process time - Drying (Granulation Parameters for 4% Tylopur 606)4.0minutes-
Process time - Granulation (Granulation Parameters for 1% Tylopur 606)20.0minutes-
Process time - Granulation (Granulation Parameters for 4% Tylopur 606)85.0minutes-
Product Temperature - Drying (Granulation Parameters for 1% Tylopur 606)31.0⁰C-
Product Temperature - Drying (Granulation Parameters for 4% Tylopur 606)29.0⁰C-
Product Temperature - Granulation (Granulation Parameters for 1% Tylopur 606)25.5⁰CEP
Product Temperature - Granulation (Granulation Parameters for 4% Tylopur 606)28.3⁰CEP
Product Temperature - warm up (Granulation Parameters for 1% Tylopur 606)31.0⁰CEP
Product Temperature - warm up (Granulation Parameters for 4% Tylopur 606)31.0⁰C-
Spraying Speed (Granulation Parameters for 1% Tylopur 606)5.4 - 11g/min-
Spraying Speed (Granulation Parameters for 4% Tylopur 606)upto 12g/min-
Particle Size Distribution
ValueUnitsTest Method / Conditions
Particle Size (x50) (Fluid Bed 1% Tylopur 606)104.0µm-
Particle Size (x50) (Fluid Bed 4% Tylopur 606)188.0µm-

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