Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Country of Origin
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 89958-09-8
- EC No.
- 289-631-2
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Features
- Anti-pollution
- Cutaneous Microbiota Balance/Protection
- Antioxidant
- Anti-inflammatory
- Barrier Function Improvement
- Biome-Friendly
- Key Attributes
- Protects skin from daily aggressions
- Reinforces the skin barrier function
- Helps to reduce cutaneous inflammation
- Enhances skin complexion
- Reduces yellowish complexion
- Reduces oxidative stress
- Reinforces the skin microbiota
- Maintains the skin microbiota balance
Applications & Uses
- Markets
- Applications
- Skin Care Applications
- Suggested Use Level
- 3%
Properties
- Physical Form
- Odor
- Characteristic
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Ex Vivo
Mechanisms of Action
Anti-inflammatory effect
Cell’intact™ fights against the harmful effects of pollution, tobacco smoke and UV rays by decreasing the pro-inflammatory response by 26%.
Skin barrier function is reinforced
Cell’intact™ prevents the degradation of Claudins-1 and -4 and restores tissue integrity, homeostasis, and the epidermal barrier.
- Microbiota Study
Air Microbiome Analysis
Sequence number of paracoccus aminovorans, according to the different zones
Trend towards an increase in the number of Paracoccus aminovorans in the highly polluted zone shows an atmospheric adaptation.
- In Vivo
Skin complexion is enhanced
PROTOCOL
- 26 women between 24 and 59 years old, living in or close to highly polluted zones.
- Hemi-face application twice a day for 28 days with Cell’intact 3% formulation and a placebo formulation.
- Evaluation at D0, D28, chromameter
- Skin complexion
- Evaluation at D0, D28, carbonyl score
- Protein oxidation
- Evaluation at D0, D28, Sequence number of Paracoccus aminovorans
- Skin microbiota
Cell’intact at 3% helps to balance skin tone by maintaining a rosy complexion and decreasing yellowish tones.
Protein oxidation is significantly reduced
As an antioxidant active ingredient, Cell’intact™ significantly reduces protein oxidation by 19.7%.
Cell’intact boosts skin microbiota
Sequence number variation of Paracoccus Aminovorans after 28 days of Application.
As a preventative anti-pollution active ingredient, Cell’intact™ significantly increases PAH-eating bacteria by up to 3 times in the skin microbiota.
Shannon index at D28 and D0 for the placebo and cell’intact™ 3%
Cell’intact™ at 3% enhances the skin microbiota composition with pollutant-eating bacteria while maintaining skin microbiota balance.