Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- CAS No.
- 1900-01-01
- Molecular formula
- C25H22O10
- Ingredients
- Milk Thistle Extract
- Product Families
- Latin Name
Silybum marianum (L.) Gaertn.
- Source of milk Thistle
Distributed in Europe, the Mediterranean region, North Africa and central Asia. It is cultivated in parks, botanical gardens or gardens all over China. Place of processing is in Shaanxi province.
- Structure of Major Constituents of Silymarin
- Active Ingredients
Silybin, Silychristin, Silydianin, Isosilybin A, Isosilybin B.
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Milk Thistle Extract Powder Benefits
a) Hepatoprotective and antioxidant effect
Silymarin can protect liver cell membranes by preventing lipid peroxidation and maintain the fluidity of cell membranes. It can also inhibit the release of superoxide anions from neutrophils to reduce liver cell damage caused by inflammatory cells. Studies have also shown that silibinin can increase the expression of superoxide dismutase (SOD) in lymphocytes in mice with chronic alcoholic liver disease, thereby playing an antioxidant role. In addition, studies have also reported that silibinin can reduce the production of reactive oxygen species (ROS) and malondialdehyde (MDA).
b) Anti-liver fibrosis
A number of studies have confirmed that silymarin can achieve anti-fibrosis effects through antioxidant and direct inhibition of the activation of various cytokines on hepatic stellate cells (HSC).
c) Liver protection and lipid-lowering effect
Experiments in mice have confirmed that silibinin can reduce the levels of triglycerides (TG) in the liver and the levels of serum TG and total cholesterol (TCh). And these animal experiments also showed that after the intervention of silibinin, the liver pathology (such as steatosis, inflammation and hepatocyte ballooning) were improved to varying degrees. Studies have also suggested that the drug can reduce the weight of test animals.
d) Anti-inflammatory effect
Silybin can reduce the levels of many pro-inflammatory cytokines, such as IL-8, IL-6, MCP-1 and TNF-α, thereby exerting anti-inflammatory effects. This effect is achieved by inhibiting the activities of IKK-β and p50 and p65, thereby inhibiting the effect of NF-κB.
- Supplements Containing Milk Thistle Extract Powder
- Puritans Pride Milk Thistle 4:1 Extract 1000 Mg (Silymarin) Softgels, 180 Count.
- Best Liver Supplements with Milk Thistle – Artichoke – Dandelion Root Support Healthy.
- Jarrow Formulas Milk Thistle, Promotes Liver Health, 150 mg Caps, 100 Count.
- Milk Thistle 1000mg Silymarin Marianum & Dandelion Root Liver Health Support.
- Zazzee USDA Organic Milk Thistle Extract Capsules, 120 Count, Vegan, 7500 mg Strength
- NOW Supplements, Liver Refresh with Milk Thistle Extract and unique Herb-Enzyme blend, 180 Veg.
- Nature’s Bounty Milk Thistle Pills and Herbal Health Supplement, Supports Liver Health.
- Life Extension European Milk Thistle-Advanced Phospholipid Delivery Soft Gels, 60 Count.
- Gaia Herbs Milk Thistle Seed, Vegan Liquid Capsules, 60Count – Liver Cleanse Supplement.
Applications & Uses
- Markets
- Food & Nutrition Applications
- Dosage of Milk Thistle Extract Powder
Although there is no standardized dose of milk thistle extract, the optimal daily intake for most people is 20-300 mg. If you want to take milk thistle to treat the liver, the recommended daily intake of milk thistle extract is 150 mg, taking 1 to 3 times a day. This is a higher dose and can be used as a natural liver detox. For continuous use and liver support, take 50 to 150 mg daily.
Properties
- Appearance
- Amorphous Powder
- Odor
- Slight, Specific
- Partially Soluble in
- Water
- Soluble in
- Methanol and Acetone
- Microbiological Values
- Specifications
| Value | Units | Test Method / Conditions | |
| Bacteria Content | max. 103 | ppm | CFU/g |
| Moulds and Yeasts | max. 102 | cfu/g | — |
| E.coli, Salmonella, S. aureus | Absence | — | CFU/g |
| Value | Units | Test Method / Conditions | |
| Molecular Weight | 482.44 | g/mol | — |
| Total Ash Content | max. 0.45 | — | — |
| Heavy Metals | max. 20 | ppm | — |
| Lead Content | max. 0.5 | ppm | ICP-MS |
| Cadmium Content | max. 1.5 | ppm | ICP-MS |
| Mercury Content | max. 0.1 | ppm | ICP-MS |
| Arsenic Content | max. 3.0 | ppm | ICP-MS |
| Loss On Drying (2h at 105°C) | max. 5 | % | — |
| Powder size (80 Mesh) | min. 90 | % | — |
| Assay of Silymarin (Standard in House) | min. 80.0 | % | UV test |
| Assay of Total Silymarin (Determined as silybin) | 30.0 - 65.0 | % | HPLC |
| Sum of silycristin and silydianin (per cent of the total) | From 20,0 to 45,0 | — | HPLC |
| Sum of isosilybin А and isosilybin В (Total %) | From 40,0 to 65,0 | — | HPLC |
| Sum of isosilybin А and isosilybin В (Total %) | From 10,0 to 20,0 | — | HPLC |
| N-hexane | max. 290 | ppm | — |
| Methanol | 3000.0 | ppm | — |
| Acetone | max. 5000 | ppm | — |
| Ethyl Acetate | max. 5000 | ppm | — |
| Ethanol | max. 5000 | ppm | — |
Regulatory & Compliance
Technical Details & Test Data
- MR Natural Milk Thistle Extract Specifications
All Available Specification:
No Product Name Specification 1 Silymarin Extracted By Acetone UV70% UV80% UV80%, Silybin + Isosilybin≥30%
HPLC 50% HPLC 55% HPLC 60% 2 Silymarin Extracted By Ethyl Acetate UV 70% UV80%, Silybin + Isosilybin≥30%
HPLC 50% HPLC 55% HPLC 60% 3 Silymarin Extracted Ethanol UV70% UV80% UV80%, Silybin + Isosilybin≥30%
HPLC 50% HPLC 55% HPLC 60% 4 Water Soluble Silymarin UV 20% UV 40% UV 45% 5 Silymarin Low Residual Solvent HPLC40% HPLC45% HPLC50% HPLC55% 6 Water soluble silybin HPLC75%, UV96%
7 Silybin HPLC70%-HPLC98%
8 Silymarin Granular/Micronization Accoroding To Customer’ Requirements
9 Silybum Marianum Oil Refine - MR Natural Milk Thistle Extract Specifications
Most popular Specifications
-
Silymarin 80% UV, no other requirements
- Silymarin UV80% & Silybin+Isosilybin HPLC30%
All available specification:
No Product Name Specification 1 Silymarin Extracted By Acetone UV70% UV80% UV80%, Silybin + Isosilybin≥30%
HPLC 50% HPLC 55% HPLC 60% 2 Silymarin Extracted By Ethyl Acetate UV 70% UV80%, Silybin + Isosilybin≥30%
HPLC 50% HPLC 55% HPLC 60% 3 Silymarin Extracted Ethanol UV70% UV80% UV80%, Silybin + Isosilybin≥30%
HPLC 50% HPLC 55% HPLC 60% 4 Water Soluble Silymarin UV 20% UV 40% UV 45% 5 Silymarin Low Residual Solvent HPLC40% HPLC45% HPLC50% HPLC55% 6 Water soluble silybin HPLC75%, UV96%
7 Silybin HPLC70%-HPLC98%
8 Silymarin Granular/Micronization Accoroding To Customer’ Requirements
9 Silybum Marianum Oil Refine -
- Manufacturing Flow Chart of Milk Thistle Extract
Raw Material → Ethanol Extraction → Concentration → Precipitation → Degreasing → Drying → Crushing, Mixing, Packaging → Product.
Safety & Health
- Milk Thistle Extract Powder Side Effects
Side effects are not common, but include: Itch, headache, diarrhea, nausea. Allergic reactions are rare but have been reported.
- Safety of Milk Thistle Extract Powder
Since milk thistle is classified as a supplement rather than a drug, it is not subject to the supervision and quality control of the Food and Drug Administration (FDA). Milk thistle is generally considered safe and well tolerated, with few reports of side effects.
Packaging & Availability
- Packaging Type
- Milk Thistle Extract Powder Package
- 25kgs/ drum, inner by double plastic bags.
- N.W./G.W.: 25kgs/ 28kgs.
- Drum size: 35cm(diameter)*51cm(height).
- Small order is accepted too. Such like 1kg/ 5kgs/10 kgs.
- Package for small quantity is by aluminum foil bag and carton box.
Storage & Handling
- Notes for Shipping
- For 1-50kg, we suggest shipping by courier, such as DHL, fedex. HS code we use is 2932999099.
- For 50-300kgs, we suggest shipping by air. HS code we use is 2932999099/1302199099.
- For more than 300kgs, we suggest shipping by sea. HS code we use is 1302199099.