SHIN-EI CHEMICAL Ag-P water

Identification & Functionality

Cosmetic Ingredients Functions

Anti-Septic,

Bacteriostatic Agent

Technologies

Cosmetic Ingredients

Product Families

Cosmetic Ingredients — Functionals

Antioxidants & Preservatives

Features & Benefits

Benefit Claims

Anti-Bacterial,

Antiseptic

Labeling Claims

Naturally Derived,

Paraben-free,

Phenoxyethanol-free

Applications & Uses

Applying Ag-P water to the Skin

Pm 2.5 and Hay Fever Measures

By applying Ag-P water to the skin, ag+ veils are worn, and it is considered that positive ion substances such as PM2.5 and pollen are repulsed. In addition, it can be expected to adsorb negative ion substances and suppress invasion from the nose and mouth. Furthermore, since the antibacterial effect is high, infection prevention from bacteria can be expected.

Properties

Physical Form

Liquid

Appearance

Colorless to light yellow, odorless liquid (good stability)

Typical Properties

	Value	Units	Test Method / Conditions
Recommended Amount of Formulation	5～50	％	-

Technical Details & Test Data

Test Method

20 g of specimens are taken in a single steril bottle and 1% (0.2 ml) of test bacteria solution is inoculated. The inoculated specimen was preserved and the number of live bacteria was measured on days 7, 14, and 21.

Bacterial and fungal challenge test in Ag-P water 10% (combined with BG5%) O/W emulsified.

Bacterial mixture
E.coli: E. coli
P.aeruginosa: Pseudomonas aeruginosa
S.aureus: Staphylococcus aureus

Fungal mixed fungus
A.niger: Black mold
C.albicans: Candida
P.citrinum: blue mold
A.pullulans: Black yeast

 

Specimen	Inoculation bacteria	Number of inoculated bacteria	7th	14th	21st
Ag-P water 10%	Bacteria mixed bacteria	2.4×108	1.0×102	<101	<101
Compounding Cream pH6.9	Fungal mixed bacteria	2.7×107	2.0×101	<101	<101

Test Method

20 g of specimens are taken in a single steril bottle and 1% (0.2 ml) of test bacteria solution is inoculated. The inoculated specimen was preserved and the number of live bacteria was measured on days 7, 14, and 21.

Challenge test of bacteria and fungi in Ag-P water 10% (2% combined with pentylene glycol) lotion

Bacterial mixture
E.coli: E. coli
P.aeruginosa: Pseudomonas aeruginosa
S.aureus: Staphylococcus aureus

Bacterial mixture
A.niger: Black mold.
C.albicans: Candida.
P.citrinum: Blue mold.
A.pullulans: Black yeast.

 

Test results 1 and 2

The challenge test showed the good result in the Ag-P water 10% compound formulation. The synergistic effect was recognized by the combination combination of BG and pentylene glycol. (Challenge test is required for each prescription)

Specimen	Inoculation bacteria	Number of inoculated bacteria	7th	14th	21st
Ag-P water 10%	Bacteria mixed bacteria	1.6×108	<101	<101	<101
Compound lotion	Fungal mixed bacteria	2.4×107	1.3×103	<101	<101

 

Test Method

Sterilization Potency Test

Test method

The number of live bacteria per hour was measured by inoculated with Propionibacterium acnes, stag beetle co., Ltd. Corynebacterium, and tooth decay bacteria (S. mutans) in 10% diluted ag-P water. The measurement of the number of live bacteria is based on the agar medium mixing method (anaerobic culture).

Test Results

Acne, corinebacterium and tooth decay bacteria were generally killed by an hour-long action.

Specimen	Inoculation bacteria	Number of inoculated bacteria	1 hour	3 hours	5 hours	8 hours
Ag-P water 10% diluted water	Acne bacteria	4.2×106	<101	<101	<101	<101
	Corynebacterium	1.2×106	9×101	<101	<101	<101

 

Specimen	Inoculation bacteria	Number of inoculated bacteria	1 min	5 mins	60 mins
Ag-P water 10% diluted water	Tooth decay bacteria	1.8×106	4.9×105	6.9×103	<101

 

Sterilization Potency Test

Test Method

Ag-P water 10% diluted water was inoculated with Candida albicans and enterohemorrhagic Escherichia coli O-157 to measure the number of live bacteria per hour. The number of live bacteria is measured by GPLP Agar Medium (C.albicans), SCDLP Agar Medium (E.coli O-157), and mixed method.

Specimen	Inoculation bacteria	Number of Inoculated bacteria	10 min	1 hour	3 hour	8 hour
Ag-P water 10% diluted water	C.albicans	1.4×106	<101	<101	<101	<101
	E.coli O-157	1.1×106	2.2×105	8<101	<101	<101

Test Results

Candida bacteria were killed for 10 minutes and O-157 was killed for an hour. It was also found that the effect continued after 8 hours.

 

Coronavirus Inactivation Test

Test Method

Testing institution: kitasato environmental science center test was conducted using feline intestinal coronavirus of the same structure as the new coronavirus.

Test Results

After 5 hours, 97. It became data to inactivate 9% coronavirus as described above, it has a long-term antiviral action, and can be expected to be applied to a highly safe and persistent formulation.

 

Specimen	Inoculator virus	Number of inoculations 0 points	5 hours later	Rate of change
Ag P water 50% aqueous solution	Feline enteric coronavirus, WSU79-1683	130,000	2,700	97.90%
Subject	Feline enteric coronavirus, WSU79-1683	130,000	180,000	3996

 

Coronavirus structure and Ag+ mechanism of action.

Coronavirus is covered with an envelope of lipid bilayers. Ag-P water (Ag+) is thought to have binds to the S (spike) part of the protein and inactivated the coronavirus.

Coronavirus structure and Ag+ mechanism of action