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Sidley Chemical COA-LH 11

Sidley Chemical COA-LH 11 is a disintegrant to prevent the tablet crack and for direct compression.

Chemical Name: Low-Substituted Hydroxypropyl Cellulose

CAS Number: 9004-64-2

Functions: Disintegrant

Synonyms: 2-Hydroxypropyl cellulose, Cellulose hydroxypropyl ether, Hydroxypropyl cellulose, Hydroxypropyl cellulose ether, Hydroxypropyl ether of cellulose, O-(2-Hydroxypropyl)cellulose, O-(Hydroxypropyl)cellulose, Oxypropylated cellulose

Technical Data Sheet
  • TypeDocument Name
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Knowde Enhanced TDS

Identification & Functionality

Pharma & Nutraceuticals Functions
CAS No.
9004-64-2
EC No.
618-388-0

Features & Benefits

character
  • White or off-white powder,no smell,tasteless;insoluble in ethanol, acetone and ether.
Execution Standard
  • Execution standard:CP2015,USP

Applications & Uses

Application
  • Mainly used as disintegrant and adhesive of solid dosage. Its powder has a large surface area and porosity so that accelerates the absorption temperature,increasing the swelling property which makes tablet easy to collapse. In the meanwhile, a larger mosaic effect among its rough structure,drugs and particles improvs the hardness and gloss of the tablet. To the drug that cannot easily be shaped, it will promote it molding, improve its hardness. To the drug with poor disintegrating property, it will accelerate the collapse so that improve the dissolution to enhanced bioavailability.

Properties

Appearance
Conforms
Typical Properties
ValueUnitsTest Method / Conditions
CategoryPharmaceutic adjuvant
Assay10.0-12.9%
Assay11.2%
Particle55μm
IdentificationConforms
PHPH 5.8
Chlorides0.05%
Loss on Drying5.2%
Residue on Ignition0.4%
Particle SizeConforms
Heavy Metalmax. 20
Femax. 0.010
Asmax. 0.0002

Packaging & Availability

Packaging Type
Packaging
  • Package - 25kg/barrel;25kg/bag