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Sidley Chemical HPMCAS

Sidley Chemical HPMCAS is mixed ester of HPMC acetate and succinic acid. It is tasteless, white to light yellow powder or granule, and mainly used for enteric coating. As enteric coating material, it has good film-forming property without plasticizer, good solubility in the upper part of small intestine (duodenum), thus can increase medicine absorption in small intestine. It can be well dissolved in acetone, ethanol- dichloromethane, acetone- ethanol- water and other solvents.

Functions: Enteric Coating System

Synonyms: 2-Hydroxypropyl methyl cellulose acetate succinate, HPMCAS, Hydroxypropyl methyl cellulose acetate succinate

    Knowde Enhanced TDS

    Identification & Functionality

    Chemical Family
    Pharma & Nutraceuticals Functions
    CAS No.
    71138-97-1
    EC No.
    615-255-9

    Applications & Uses

    Manufacturing Technology

    Properties

    Typical Properties
    ValueUnitsTest Method / Conditions
    Viscosity2.4-3.6mPa.s
    Methoxy12 - 28wt, %
    Free acetic27.0-35.0wt, %
    Hydroxypropoxy4 - 23wt, %
    Loss on dryingmax. 5.0%
    Residue on ignitionmax. 0.20%
    Heavy metalsmax. 10ppm

    Regulatory & Compliance

    Compliance
    • Comply with USP33

    Technical Details & Test Data

    Content
    Content LG MG HG
    Acetyl group 5.0-9.0 7-11 10-14
    Butyl two acyl group 14-18 10-14 4-8

     

    Packaging & Availability

    Packaging Type
    Packaging
    • PACKAGING: 10KG/barrel or 25KG/barrel lined with inner PE bag.