Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Ingredient Origin
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Beta-Glucans
Features & Benefits
- Benefit Claims (Health)
- Food Ingredients Features
- Product Background
- Beta-glucans are polysaccharides that naturally occur in cereals, yeast, fungi and algae. It is touted as nature’s immune-modulator, helping to prime immune cells and support and balance natural immunity. Beta-glucans are found on the surface of disease-causing fungi. The immune system has evolved to recognize these molecules with a specific receptor on white blood cells that activate the immune system following the binding to the beta-glucans.
- BioGlena™ a high source of Beta-Glucans: Euglena gracilis is a single-cell microalga, living in most freshwater habitats. It naturally produces linear 1-3 beta-glucans called paramylon, which are stored as free-floating granules in the cell, and known for their immunomodul functions. Euglena grcaillis accumulates a large amount of beta-glucans within its cells and uses them as a major energy storage compound. The algae also contain complete proteins, essential vitamins, and minerals.
- Product Benefits
- BioGlena™ taken orally is easily digested in the stomach, effectively releasing the beta-glucans from within the algal matrix where they are picked up by immune cells in the intestine and transported to key sites in the body. This initiates a cascade of immune signaling and immune cell priming, helping to naturally strengthen the innate and adaptive immune system against pathogens.
- Beta Glucan Immune Support Mechanism - Triggering of trained immunity, priming of key immune cells, activation of the immune cascade, strengthening of innate & adaptive immunity.
- Beta-Glucans Induce Trained Immunity - Trained immunity is a newly identified immune mechanism that describes a functional reprogramming of innate immune cells following exposure to stimuli, which leads to an enhanced response toward a second stimulus.
- Vegan, NON-GMO, Gluten free, Allergen free
- BioGlena™ Immune Supporting Ingredient
- Beta-glucan is an active ingredient scientifically proven to support the immune response.
- BioGlena™ is easily digested in the stomach and the Beta-glucan is released from within the alga.
- Beta-glucan is picked up in the digestive system by immune cells which shuttle it throughout the body to key immune sites. This initiates a cascade of immune signaling and immune cells priming, ultimatelystrengthening our natural innate and adaptive immune Support to pathogens.
- Support of innate & adaptive immunity
- Priming of key immune cells
- Supports immune balance
- Triggering of "trained immunity"
Applications & Uses
- Applications
- Food & Nutrition Applications
- Use Level
- 375 mg/day (Dietary supplements), max. 450 mg/serving (Food)
- Product Applications
- Capsules
- Tablets
- Soft gels Gummies
- Powder
- Functional food
- This food ingredient is applicable to multiple food categories
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Beta Glucans Induces Trained Immunity
Beta-glucans are typical inducers of trained immunity, which can be induced in three phases:
- Unstimulated immune cells, such as macrophages, bind Beta-glucans via the dectin-1 receptor and are thereby activated and undergo functional epigenetic reprogramming and associated metabolic changes, preparing the cells for future encounters with pathogens.
- The cells are resting (not active) but are trained (primed) and ready for action.
- Trained/primed cells encounter a pathogen (or experimental pathogen mimic) and respond more effectively and powerfully than non-trained/non-primed cells.
Test Data: The effect of BioGlena was evaluated in an in vitro study with human macrophages. The cells were incubated with BioGlena or neutral controls for 24 hours, followed by a five-day rest period. At the end of the resting period, the cells were incubated with bacteria and viruses. The results demonstrated that macrophages exposed to BioGlena responded more effectively to the pathogens compared to controls.
Storage & Handling
- Shelf Life
- 3 Years