Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Animal Feed & Nutrition Functions
- Ingredients
- Albendazole
- Technologies
Features & Benefits
- Animal Feed & Nutrition Features
Applications & Uses
- Markets
- Dose
Oral route of administration
- Cattle: Treatment of nematodosis and cestodosis: 0.75 ml of medicine/10 kg bw, in a single dose
- Sheep: Treatment of nematodosis and cestodosis: 0.5 ml of medicine/10 kg bw, in a single dose
- Wait Time
- Meat:
- Cattle: 14 days
- Sheep: 10 days
- Milk: 96 hours
- Meat:
Properties
- Physical Form
- Active Ingredient
- Pharmacological Properties
Pharmacodynamic properties:
Albendazole is an antiparasitic used for the treatment of diseases caused by nematodes, trematodes and cestodes sensitive to its parasiticidal action, both in adult forms and in larvae. It acts by inhibiting the energy metabolism of parasites thanks to its ability to act on enzyme systems and on the capture of their energy sources. This interference causes a decrease in the availability of the energy necessary for the normal functioning of the vital organs of the parasites, which leads to a depletion of their energy sources causing their death. It also has a high affinity for tubulin in parasite cells, preventing its polymerization. Its binding to tubulin during microtubule growth causes inhibition of mitosis. Resistance to benzimidazole anthelmintics develops primarily through loss of receptors or reduced affinity of receptors for drugs. In the case of albendazole, resistance is strongly linked to reduced affinity forβparasitic tubulin. However, the resistance mechanism is quite complex and can vary between different genera and species of parasites. The resistance of parasites to benzimidazoles can be crossed, between drugs of the same or different family. Resistance to benzimidazoles can be considered to exist when the percentage reduction of eggs in feces is less than 95% with a confidence interval of less than 90%.
Pharmacokinetic data:
Albendazole is relatively well absorbed after oral administration in cattle and sheep (approximately 50% bioavailability). It undergoes a complex process of biotransformation and enterohepatic recirculation. The main metabolites are albendazole sulfone and albendazole sulfoxide. The latter has anthelmintic activity and is supposed to be the main responsible for the systemic activity of albendazole treatments.
| Value | Units | Test Method / Conditions | |
| Albendazole | 100.0 | mg | — |
| Benzoic Acid | 1.0 | mg | — |
| Potassium Sorbate | 1.5 | mg | — |
Packaging & Availability
- Packaging Type
- Available Packaging
- 100ml
- 1L
- 5L
- Nature and composition of primary packaging
- Opaque high-density polyethylene bottle, white, closed with a screw cap of the same nature and sealed by induction.
- White high-density opaque polyethylene container, closed with a screw cap of the same nature and sealed by induction.
Storage & Handling
- Special Precautions for Storage
This veterinary medicinal product does not require any special storage conditions.
- Disposal
Any unused veterinary medicinal product or residues derived from it must be disposed of in accordance with local regulations.