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ESC® Eggshell Calcium

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Ingredient Name: Eggshell Calcium
Function: Supplement, Mineral
Animal Species: Rabbit, Pets, Cats, Dogs
Labeling Claims: Gluten-free, TSE-free, Natural, Organic, Halal, Kosher, Naturally Derived, Solvent-free, Non-GMO, BSE-free
Certifications & Compliance: NSF Approved, California Proposition 65, Oregon Tilth Certified Organic (OTCO), GMP, Halal, United States Pharmacopeia (USP), Generally Recognized As Safe (GRAS), USDA Organic, Organic Certified, Kosher
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TypeDocument Name
ESC® Information Sheet
ESC® Information Sheet

Knowde Enhanced TDS

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Identification & Functionality

ESC® Eggshell Calcium Features & Benefits

ESC® Standard Eggshell Calcium Overview

ESC combines ultra-pure calcium carbonate with inherent transport proteins for better absorption and essential trace minerals for supporting bone mineral density. The high elemental calcium (minimum 35%) allows for a smaller dose and greater formulation ease.

  • Bone Support
  • Healthy Aging
  • Sports Nutrition
  • Ovo-Vegetarian

Applications & Uses


Physical Form
Off-white to light pink powder
Physical Properties
ValueUnitsTest Method / Conditions
Bulk Density (loose)min. 0.7g/ccESM-TM-PH003
Bulk Density (tapped)min.1.0g/ccESM-TM-PHO03
Particle Size (Retained On #60 Mesh)max. 5%ESM-TM-PHOO2
Typical Properties
ValueUnitsTest Method / Conditions
Moisture Contentmax. 5%ESM-TM-CHOO5
Microbiological Values
ValueUnitsTest Method / Conditions
Coliformmax. 100cfu/gAOAC 991.14 or ESM-TM-MBO06
Escherichia coliNegative/25gUSP 30 <61> or ESM-TM-MBO006
Pseudomones aeruginosaNegative/25gUSP 30 <61> or ESM-TM-MBO06
SalmonellaNegative/25gUSP 30 <61> or ESM-TM-MBO006
Staphylococcus aureusNegative/25gUSP 30 <61> or ESM-TM-MBO06
Total Aerobic Countmax. 5,000cfu/gAOAC 990.12 or ESM-TM-MBO06
Yeast and Mold Countmax. 300cfu/gAOAC 997.02 or ESM-TM-MBO06
Nutritional Information
ValueUnitsTest Method / Conditions
Calcium Carbonatemin.87%ESM-TM-CHO01 (USP 30)
ValueUnitsTest Method / Conditions
Elemental Calciummin. 35%ESM-TM-CHO01
Heavy Metals
ValueUnitsTest Method / Conditions
Arsenic Contentmax. 0.15ppmAOAC 993.14 (ICP-MS)
Cadmium Contentmax. 0.05ppmAOAC 993.14 (ICP-MS)
Lead Contentmax. 0.05ppmAOAC 993.14 (ICP-MS)
Mercury Contentmax. 0.05ppmAOAC 993.14 (ICP-MS)

Regulatory & Compliance

Technical Details & Test Data

Test Data

Eggshell Calcium Increases Bone Mineral Density in Healthy Post-menopausal Women*

A randomized, double-blind, placebo-controlled human clinical trial - the gold standard of scientific research - took place over 12 months observing the long-term effects of eggshell calcium on bone mineral density. Eighty-five healthy women, 50-70 years of age who were at least 5 years post-menopausal were studied. The subjects were given either calcium carbonate or eggshell calcium, both supported with Vitamin D and Magnesium, and the effects on bone mineral density (BMD) of the femoral neck were evaluated. The published study can be found in the British Journal of Nutrition.

Figure 1. % Change in Femoral Neck Bone Density with Eggshell Calcium, Calcium Carbonate & Control

ESC® Eggshell Calcium - Test Data

  • After 12 months of supplementation, women given eggshell calcium demonstrated a significant increase in BMD of the femoral neck (Figure 1). Similar supplementation with calcium carbonate resulted in nearly a third smaller increase in BMD, while the control group actually lost BMD. The study concluded that supplementation with eggshell calcium can increase BMD of the hip within 12 months in healthy, late post-menopausal women.
  • Eggshell calcium is supported by many other clinical studies, as well.


Eggshell Calcium’s Crucial Transport Proteins Enhance Absorption & Utilization in the Bones

  • Two studies were conducted for seven days on 23 piglets that looked at the bioavailability of eggshell calcium in comparison with calcium carbonate (CaCO3). In addition, the influence of casein and soy protein on calcium absorption was studied. Results showed that eggshell calcium was more digestible than the calcium from purified CaCO3. In the case of casein-based protein diets, eggshell calcium was as good a source of calcium as CaCO3, and in the case of soy-based protein diets, eggshell calcium significantly outperformed CaCO3. The study concluded that eggshell calcium is a good source of calcium for growing piglets, which have similar digestive systems to humans.
  • Furthermore, a separate in vitro study was conducted to evaluate calcium transport of eggshell calcium in human intestinal epithelial cells. The study found that soluble eggshell matrix proteins remarkably enhance calcium transport across Caco-2 monolayers. In the presence of whole eggshell matrix proteins, 64.3% more calcium was transported.


Packaging & Availability

Packaging Type

Bulk Packaging : 20 Kg Poly-Lined Boxes

Storage & Handling

Recommended Retest Interval <36 MO.
Reserve Sample Quantity 400 - 500 g
Bulk & Sample Storage Condition 65 - 85 °C
Reserve Sample Container min. 16 OZ. POLY BAG


ESC® Eggshell Calcium
Stratum Nutrition