Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Vitamin Type
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Technical Advancement of WS Biotinᵀᴹ
WS Biotinᵀᴹ is a water-soluble, dry powder form of D-Biotin (50% w/w). Tagra’s unique technology makes life easier for formulators: Formulating with WS Biotinᵀᴹ results in a pH of 6-8 and does not require using any solvents for solubilizing Biotin. It prevents any risk of crystallization in the formula, therefore, maintaining its potency, and it is added to the formulation at room temperature using a simple paddle mixer or homogenizer, as needed. With this increased versatility and redefinition of biotin as an easy-to-incorporate ingredient, Tagra's WS Biotinᵀᴹ solution becomes the perfect addition to a wide range of cosmetic products.
- WS Biotinᵀᴹ Benefits for End Users
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WS Biotinᵀᴹ is highly beneficial for the end-user, as Biotin is known for its ability to strengthen hair and nails, and improve skin health, and with our water-soluble technology, the biotin in our product is more readily available for the hair and skin to absorb, providing more effective treatments for the user. By offering a dramatically higher solubility level of 2g/100ml compared to 0.02g/100ml for free Biotin, WS Biotinᵀᴹ also creates highly concentrated formulas for customers. Tagra revolutionizes the skin, hair, and scalp care industries by enabling cosmetic manufacturers to deliver previously unattainable formulas and performance.
Applications & Uses
- Markets
- Application Format
- Hair Care Applications
- Skin Care Applications
- Use Level
- 1.2%
Properties
- Physical Form
- Soluble in
- Water
- Typical Properties
- Solubility
| Value | Units | Test Method / Conditions | |
| pH | 6 - 8 | — | — |
| Value | Units | Test Method / Conditions | |
| Water | 2.0 | g/100ml | — |
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
Technical Details & Test Data
- In-vitro (Hair Care)
The in vitro treatment with 0.1% of WS Biotinᵀᴹ water solution in Human Follicle Dermal Papilla Cells (HFDPC), displays hair growth-stimulating eects, substantiated in a significant upregulation of Fibroblast Growth Factor 7 (FGF7) compared to the untreated control.
In-vitro assay results for stimulating the gene expression of Fibroblast Growth Factor 7 (FGF7).
The results show that the treatment with WS Biotinᵀᴹ at 0.1% significantly upregulated gene expression by 122.1 %, versus untreated control.- In-vitro (Skincare)
Melanin is primarily responsible for the pigmentation of human skin, eyes and skin. Among other stimuli, ultraviolet radiation triggers the biosynthesis of melanin and the subsequent melanosome transfer to epidermal keratinocytes.
We assessed the inhibitory capabilities of WS Biotinᵀᴹ on melanin biosynthesis through a 72-hour in vitro treatment on Normal Human Epidermal Melanocytes (NHEM) that were subjected to irradiation with ultraviolet A (UVA) irradiation, followed by a 48-hour period of intracellular melanin accumulation.
Results obtained from cells co-exposed to UVA and WS Biotinᵀᴹ for 72 hours, strongly suggested that this product at 0.1 % displays whitening activity demonstrated by a reduction of UVA-induced melanin levels by 18.4 % compared to the untreated Control + UVA.
Effect of WS Biotinᵀᴹ on the UVA-induced accumulation of melanin:
Bar graph representing intracellular melanin levels, after 3 days of simultaneous exposure to UVA (30 J/cm2) and treatment with WS BiotinTM, followed by 2 days of melanin accumulation in the presence of WS Biotinᵀᴹ in Normal Human Epidermal Melanocytes
- Formulate with WS Biotinᵀᴹ
Hair Care: WS Biotinᵀᴹ is a pertinent solution for haircare (shampoos, conditioners, serums, aerosol) products Formulating with WS BiotinTM results with a pH of 6-7 and does not require using any organic solvents for solubilizing D-Biotin. It prevents any risk of crystallization in the formula, and it is added to the formulation at room temperature. No mixing process is required as the WS Biotinᵀᴹ is being solubilized spontaneously.
Skin Care: WS Biotinᵀᴹ is a potent and practical solution for skincare (serum, creams, gel) products. Formulating with WS BiotinTM results in a pH of 6-7 and does not require using any organic solvents for solubilizing D-Biotin. It prevents any risk of crystallization in the formula, and it is added to the formulation at room temperature. No mixing process is required as the WS BiotinTM is solubilized spontaneously.
Left: WS Biotinᵀᴹ water solution at 4% (equivalent to 2% free D-Biotin) after 30days incubation at 10°C.
Right: 0.1% water solution of free D-Biotin after 24h incubation at 10°C.
Water solubility of WS Biotinᵀᴹ in comparison to free Biotin
Crystals were formed in the free D-Biotin solution while no crystals were formed in the WS Biotinᵀᴹ water solution
Storage & Handling
- Storage Condition
Closed container at ambient temperature