Knowde Enhanced TDS
Identification & Functionality
- Chemical Name
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 9005-80-5
- EC No.
- 232-684-3
- Technologies
Features & Benefits
- Benefit Claims
- Labeling Claims
- Key Features
- Microbiota support against preservatives
- Skin hydration that outperforms hyaluronic acid
- Supports skin microbiota to reduce effects of aging
- Natural inulin-based prebiotic derived from chicory and agave
- Selectively supporting benefi cial organisms
- Global compliance (including China)
Applications & Uses
- Markets
- Applications
- Use Level
- 0.5 – 3%
- Formulation Guidelines
- Recommended dosage: 0.5 – 3%
- pH range: 4.3 – 10.0
- Temperature: <60°C for durations up to 8 hours
- Add to and dissolve in the water phase
- Can be dispersed in oil and esters
- Prolonged and high-temperature exposure can lead to slight yellowing
- Avoid strong oxidizing agents (e.g. peroxides)
- Avoid reducing agents
Properties
- Odor
- Typical, slight
- pH
- 4.3 – 10.0
Technical Details & Test Data
- Skin Hydration by preBIULIN AGA
preBIULIN AGA provides skin hydration that outperforms hyaluronic acid as demonstrated in short- and long-term tests. Creams formulated with 0.1% of high MW hyaluronic acid (1.6MDa) and 1.5% preBIULIN AGA were tested up to 28 days, showing consistently higher hydration levels for preBIULIN AGA.
Skin hydration in a function of time after 1 application of cream containing 0.1% HA and
1.5% preBIULIN AGA, expressed as a percentage improvement verses initial value. Measuring using Corneometer CM285.
Skin hydration after 28 days of twice daily application of cream containing 0.1% HA and
1.5% preBIULIN AGA, expressed as a percentage improvement verses initial value. Measured using a Corneometer CM285.- Protection Against Preservatives
- Preservatives are a must in a finished formulation. Although they are beneficial in maintaining the integrity of a formulation by protecting it from contamination, they can have a negative impact to the skin microbiota. preBIULIN AGA supports the microbiota against the changes that happen to skin when exposed to preservatives, with the additional benefit of skin hydration.
- Tests were performed where creams containing a strong preservative system with and without preBIULIN AGA were applied onto cheeks. The total count and diversity of the microbiota in function of time shows how preservatives disrupt the microbiota. Without preBIULIN AGA the microbiota had not recovered after 4 hours, whereas preBIULIN AGA accelerated the recovery. It was also found that the diversity of the microbiota is closer to the original situation, suggesting less colonization by foreign organisms than without preBIULIN AGA.
Skin Microbiota Population
Microbiota count in function of time after applying cream containing a strong preservative system, with and without preBIULIN AGA. Microbiota count is measured using dip slides, incubated at 37°C for 48h.
Diversity of Skin Microbiota
Microbiota diversity 4h after application of cream containing a strong preservative system with and without preBIULIN AGA. Profiling done by DNA sequencing using 16S (bacteria) and UNITE ITS (fungi) gene databases. Values expressed as percentage difference verses initial situation.
- preBIULIN AGA supports the growth of the microbiota, leading to a count that can exceed its initial value which can be beneficial for aging skin where microbiota counts are typically low due to lower skin cell renewal and levels of sebum production, providing less food for microorganisms than younger skin.
- preBIULIN AGA does not alter the preservative effects in formulations.