Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Lactobacillus Fermentums
Features & Benefits
- Benefit Claims (Health)
- Food Ingredients Features
- Probiotic Strain Of Human Origin
Lactobacillus fermentum ME-3® was isolated in 1995 at the University of Tartu, Estonia, from a healthy one year old child. The strain displays excellent probiotic properties, resistance to gastro-intestinal environment (bile acids, low pH), lectin profile suitable for adhesion to gut epithelial cells. QPS status, safety demonstrated by human clinical trials and long history of human consumption without side effects.
- Metabolic Health, Fatty Liver
A recent animal study on obese, diabetic mice has shown more remarkable benefits of L. fermentum ME-3® consumption. Animals treated with the probiotic had reduced weight gain compared to controls, as well as improved glucose tolerance. Liver health was improved with a 40% reduction of fatty acid accumulation (ME-3® prevents fatty liver/NASH) and lower liver inflammation markers. L. fermentum ME-3® also exerted a protective action against glycation-induced kidney damage.
Applications & Uses
- Applications
- Dosage Form
Technical Details & Test Data
- ME-3® Antioxidant Effects
ME-3® is one of the very few probiotic strains to contain a complete enzymatic system enabling synthesis, uptake and redox regeneration of reduced glutathione. Glutathione is a major free radical scavenger and antioxidant, used by the enzyme glutathione peroxidase to inactivate harmful peroxides. Glutathione also contributes to maintain other antioxidants like vitamin C and vitamin E in their active forms. ME-3® consumption leads to an increase of the reduced/oxidized glutathione ratio in the body, and to an overall improvement of oxidative status.
In addition to its effect on glutathione pathways regulation, L. fermentum ME-3® expresses Mn-SOD, a potent antioxidant enzyme. This is another mechanism by which the strain contributes to protection against oxidative damages.- ME-3® And Cardiovascular Health
Several properties of ME-3® make it a strain of choice for use in cardiovascular health formulations. The most remarkable is its capacity to reduce LDL cholesterol oxidation. Oxidized LDL (oxLDL), whose formation is favored by increased oxidative stress, inflammation, high homocysteine levels, is a major contributor to atherosclerosis.
ME-3® consumption also raises the levels of paraoxonase enzyme in the blood; paraoxonase is an antioxidant enzyme which protects LDL particles against oxidation. Paraoxonase also inactivates toxic derivatives of homocysteine, a molecule associated with inflammation and cardiovascular disease.Another beneficial effect of ME-3® is the regulation of lipid metabolism. L. fermentum ME-3® consumption led to a reduction of borderline high LDL-cholesterol and triglyceride levels in several food interventions and clinical studies. LDL-C to HDL-C ratio, oxLDL values, and postprandial lipemia were also improved.
- Anti-bacterial Effects
L. fermentum ME-3® shows potent anti-bacterial activities against several gastro-intestinal pathogens: E. coli, Salmonella enterica, Shigella sonnei (in vitro studies); Salmonella typhimurium (mouse model for enteric fever), Citrobacter rodentium (mouse model for E. coli infections). These anti-microbial properties correlate with the production of lactic acid, acetic acid and succinic acid.