Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Bifidobacterium Lactis, Bifidobacterium Longums, Bifidobacterium Breves, Bifidobacterium animalis
Features & Benefits
- Food Ingredients Features
- Product Background
The gastro-intestinal (GI) tract and microbiota of a newborn baby distinctly differ from that of adults. The first years of life are a critical period for gut colonization and the development of a healthy, balanced core gut microbiota.
Figure 1: Main mechanisms of probiotic activities in infants. Source Chassard et al.1
After birth, a newborn is exposed to environmental microbes which immediately colonize the GI tract. The first two till three years of life a dynamic interplay occurs between host cells, the immune system, and successive bacteria. The first microbes to colonize the infants’ gut are mostly Bifidobacterium species. These first bacterial species are critical for the development of a healthy adult microbiota and a properly functioning immune system later in life.1 Several factors influence the development of the microbiota of the baby. Natural delivery and breastfeeding have been associated with beneficial health effects related to gut colonization and development and low incidence of immunological disorders. More and more diseases are linked to dysbiosis of the microbiota of neonates. Allergy, colic, and even obesity are now associated with a less diverse microbiota or lack of bifidobacteria and lactobacilli in the infant’s gut.2 Probiotics can provide infants with the necessary beneficial microbes to prevent diseases and restore the microbial balance. Winclove Baby is well tolerated by infants and is safe to use.
- Strain Selection
Winclove Baby is a broad-spectrum, multispecies probiotic formulation developed for managing and maintaining the intestinal balance of infants. The formulation contains 4 specially selected probiotic strains. Probiotic strains can exert health effects at different levels in the gut (see figure 2). The probiotic strains of Winclove Baby are active on all three levels. The strains have been screened for their capacity to:
- inhibit various pathogens such as C. difficile and E. coli
- improve the barrier function
- influence the immune system
Figure 2: Probiotic strains can be active on three levels in the gut. The strains in Winclove Baby have been proven active at all three levels.
Applications & Uses
- Markets
- Applications
- Food & Nutrition Applications
Properties
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- In Vitro Evidence
The most dominant genera in the healthy infant’s gut is Bifidobacterium. Therefore, Winclove Baby consists of four Bifidobacterium species, of which research has shown to be present in the gut of infants.3 These Bifidobacterium species can restore the balance of the new-born’s microbiota. Three strains of Winclove Baby have been added for their ability to inhibit growth of E. coli, a pathogen associated with infant colic. These strains have shown good capability to inhibit growth of E. coli (figure 3). Maintenance of the intestinal barrier function is critical for essential physiological processes. Three strains of Winclove Baby have been added for their ability to protect the integrity of the intestinal lining. Their efficacy has been tested in a Trans Epithelial Electrical Resistance (TEER) model. All strains were capable to strengthen the intestinal barrier function when a stressor was added. (figure 4). Disruptions in the early microbiota can cause an imbalance in immune response regulating cells (Th1/Th2), which is one of the main mechanisms behind the development of allergies and asthma. All the strains in Winclove Baby are selected and tested to maintain a balanced immune system by inducing the production of IL-10; a cytokine with anti-inflammatory effects. (figure 5).
Figure 3: Inhibition of E.coli by three strains in Winclove Baby. The larger the zone, the better the inhibition
Figure 4: TEER data of three strains in Winclove Baby. The higher %TEER, the better the barrier function.
