Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Bifidobacterium Lactis, Lactobacillus Acidophilus, Lactobacillus Casei, Streptococcus salivarius
Features & Benefits
- Food Ingredients Features
- Product Background
The human gastro-intestinal (GI) tract harbors trillions of microbes, the so-called gut microbiota, which plays an essential role in infant and child health. Disturbances in the gut microbiota have been associated with a variety of health problems.
Figure 1: Diseases linked to disturbances in the gut microbiota of children.
The development of the microbiota already starts in utero and continues to evolve the first years of life1 . During our lifetime the microbiota co-develops with our immune system. The establishment of a diverse and stable microbiota in early life is important to maintain health later in life.1,2 Besides successful early life colonization, the microbial composition is largely influenced by environmental factors such as; antibiotic-use, unhealthy diet, householdsetting, spoiled food or medical interventions.2,3,4 Disturbances in the gut microbiota have been shown to affect the child’s health and behavior. Pediatric diseases known to be associated with gut-dysbiosis include; antibiotic associated diarrhea, functional gastro-intestinal diseases, constipation, obesity, gastrointestinal infection, atopic disorders, (food) allergies, inflammatory bowel disease, celiac disease, type 1 diabetes and urinary tract infections.5 Fortunately, as described in a report of the World health Organization (WHO), the use of probiotics can be used as a therapeutic intervention to manage the microbial populations.6 Probiotics can provide infants with the necessary beneficial microbes to restore the microbial balance and prevent diseases.
- Strain Selection
Winclove Junior is a broad-spectrum, multispecies probiotic formulation developed for managing and maintaining the intestinal balance of children. The formulation contains 6 specially selected probiotic strains. Probiotic strains can exert health effects at different levels in the gut (see figure 2). The probiotic strains of Winclove Junior are active on all three levels. The strains have been screened for their capacity to:
- inhibit various pathogens such as; C. difficile, E. coli, Salmonella, Shigella and P. agglomerans
- improve the barrier function
- stimulate a less allergic response of the immune system by; inducing T-and B-cell proliferation, increasing IFN-y and IL-10 production and decreasing IL-5 and IgE production
Figure 2: Probiotic strains can be active on three levels in the gut. The strains in Winclove Junior have been proven active at all three levels.
Applications & Uses
- Markets
- Food & Nutrition Applications
Properties
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Clinical Evidence
In a post-marketing study among therapists in the Netherlands it was investigated for which indications Winclove Junior is prescribed and how its use is experienced (positive/negative). The results of this survey are shown in figure 3. As can be seen in the graph, Winclove Junior is prescribed for many health problems and shows the most satisfying effect (100%) for use during antibiotic use. Also for the other indications, high satisfaction scores (60%-80%) were obtained (data not published).
Figure 3: Results of a post-marketing survey with Winclove Junior
In addition, Winclove Junior has been studied in another post-marketing survey investigating the effect of Winclove Junior on childrens’ health. 80 children in the age of 0.5 – 6 years old used the probiotic for 6 weeks. A general health questionnaire was filled out by their healthcare professional together with the parent(s). Results showed that Winclove Junior significantly increased health and improved appetite, see figure 4. The researchers reported no side-effects (data not published).
Figure 4: Results of a post-marketing survey with Winclove Junior. * Significant effect.
