Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Bifidobacterium Lactis, Vitamin D3, Lactobacillus Paracasei, Lactobacillus Acidophilus, Bifidobacterium Bifidum, Streptococcus salivarius, Lacticaseibacillus rhamnosus, Lactiplantibacillus plantarum
Features & Benefits
- Food Ingredients Features
- Product Background
Global life expectancy for men and women has increased about six years over the past two decades.¹ However, aging comes hand in hand with all sorts of infirmities of which many of them are related to age-impaired functioning of the gut microbiota.
Figure 1: The microbiota over time and inflammaging. Source; Nikoletopoulou V, et al. (2014) and Ottman et al. (2012).
The microbiota changes during life and an aging microbiota is characterized by decreased diversity, reduced levels of beneficial bacteria and increased pathogenic and inflammatory species.2,3 Also, an aging immune system gradually decreases in functioning, resulting in a low-grade chronic inflammatory state, also referred to as “inflammaging”.4 Inflammaging is linked to most age-related health problems, such as; dementia, Alzheimer or atherosclerosis2 . This inflammatory state affects the gut microbiota and vice versa, as age-related changes in gut microbiota composition nurture an abnormally activated immune response2 . Moreover, the gut microbiota of elderly is affected by modifications in lifestyle and nutritional behavior. Physical activity is reduced and often more than one medicine is used. Dietary choices and food digestion are changed by reductions in dentition, chewing ability and taste.5 These alterations in composition and functioning of the intestinal microbiota are related to the progression of diseases and frailty in the elderly population. Therefore, balancing intestinal health and maintaining a healthy gut microbiota composition is essential for healthy aging and quality of life. Manipulation of the gut microbiota of elderly by probiotics is an effective strategy to influence the development of infirmities associated with aging.
- Strain Selection
Winclove Senior is a broad-spectrum, multispecies probiotic formulation developed for managing and maintaining the intestinal balance of older adults. The formulation contains 10 specially selected probiotic strains. Probiotic strains can exert health effects at different levels in the gut (see figure 2). The probiotic strains of Winclove Senior are active on all three levels. The strains have been screened for their capacity to:
- inhibit various pathogens such as; E. coli, Salmonella, Shigella and P. agglomerans
- improve the barrier function
- influence the immune system.
Figure 2: Probiotic strains can be active on three levels in the gut. The strains in Winclove Senior have been proven active at all three levels.
Applications & Uses
- Markets
- Food & Nutrition Applications
Properties
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- In Vitro Evidence
Winclove Senior contains 10 bacterial strains. In addition, vitamin D3 has been added to the formulation. Vitamin D contributes, among others, to the maintenance of normal bones, teeth and muscle function. Vitamin D status is often impaired in elderly. Winclove Senior has been tested in vitro on:
Inhibition of Clostridium difficile. Elderly are more susceptible to C. difficile infections. Three bacterial strains have been added to the formulation to inhibit growth of C. difficile. In vitro testing has shown excellent capability of these strains to inhibit C. difficile, see figure 3.
Strengthening the barrier function. Aging comes with an impaired intestinal barrier function. Three bacterial strains have been added to strengthen the intestinal barrier function. The results of in vitro testing with two strains in a Trans Epithelial Electrical Resistance (TEER) model are shown in figure 4. Both strains are very well capable of strengthening the intestinal barrier function. The third strain also performed well in a different model
Boosting the immune system. The immune system gradually decreases in older people. Three bacterial strains have been added to the formulation to boost the immune system. These strains have shown good induction of Th1 cells, which are involved in promoting immune responses and defense. (Results not shown).
