TopicOil™

Identification & Functionality

Cosmetic Ingredients Functions

Carrier

Pharma & Nutraceuticals Functions

Carrier

Technologies

Cosmetic Ingredients,

Pharmaceuticals & Nutraceuticals

Product Families

Pharmaceuticals & Nutraceuticals — Excipients

Carriers & Bulking Agents

Cosmetic Ingredients — Functionals

Solvents & Carriers

Features & Benefits

Benefit Claims

Free Of Off-Odors,

Freeze Stability,

Hydrating,

Improves Hydrophobic Properties,

Moisturizing

Labeling Claims

Emulsifier-free

Features

• Steam sterilizable, free of emulsifiers
• Formulated for RT° stability at pH 4.5 as a topical
• It forms a sealing surface, lasting hours after the antifungal or drug is delivered
• Yoil-Cream is formulated as pure neutral pH cream
• Yoil-Cream resists gastric acid, for oral delivery
• Non-emulsion, white cream, gastric acid tolerant, freezable
• High availability
• High drug loading
• Low manufacturing complexity
• High physical and chemical stability
• Steam sterilizable

Product Highlights

• Topicoil™ with higher drug-carrying capacity, smoother texture and sealing properties unlike anything else on the market.
• Topical formulations for hydrophobic drugs have limited options. Hydrophobic drug formulations feel oily and skin-drying emulsifiers are undesirable.
• Commercial liposomes have been used, but their diameters are less than 0.2 microns. Low volume to surface ratios affect drug loading. Emulsion formulations have similar limitations.
• Xylome’s TopicOil™ drug delivery platform provides a radically new and greatly improved solution to hydrophobic and hydrophilic topical drug delivery. Xylome’s highly purified TopicOil™ lipid bodies are an order of magnitude larger in diameter – ranging from 5 to 12 microns on average.
• TopicOil™ are moisturizing macro-carriers for higher levels of hydrophobic drug delivery that feels aqueous

Applications & Uses

Markets

Healthcare & Pharma,

Personal Care

Applications

Personal Care — Beauty & Care

Skin Care

Healthcare & Pharma — Drug Delivery & Care Solutions

Oral,

Topical

Application Format

Creams,

Leave On,

Lotions

Dosage Form

Creams

Properties

Physical Form

Liquid,

Solid

Odor

Odorless

Taste

Tasteless

Technical Details & Test Data

Comparison of TopicOil™ by Xylome to ForumMax™

Comparable Product Comparison	Average Diameter (Mean Particle Size)	Volume (Cubic μMs)	Lipid content in 5ml	Expected Drug Loading
Topicoil
FormuMax*	7 microns	174 cubic μM	2500 mg	10-20 mg/ml
PEGylated liposomes for hydrophobic drugs	0.1 microns	0.00052 cubic μM	220 mg	1-2 mg/ml
The Difference	6.8 microns per particle	332,000x-fold	11.4x-fold	>10x per ml