Knowde Enhanced TDS
Identification & Functionality
- Surface Modification/Functionality
Aqueous Non Aqueous C4 SiO2 Phenyl Cyano (Can be used in both NP & RP systems)
C8 Diol (Can be used in both NP & RP systems)
C18 NH2 (Can be used in both NP & RP systems)
- NH2P - SAX Thiol (SH) & NH2 phases available for scavenging electrophiles and toxic heavy metals
Applications & Uses
- Chromatographic Separations/ Purification of
- Analytic- up to Process-Scale
- (Bio) Pharmaceuticals
- APIs and Intermediates
- Typical Applications
- API
- Intermediates
- Small Molecules
- Natural Products
- Food
- Flavors
- Fragrances
- Lipids/oils/fats
- Carbohydrates
- Pigments
- Cosmetics
- Biomolecules
- Peptides
- Insulin Analogs
- Oligonucleotides
- Proteins
- Heavy metal scavengers
- Specialized in the Purification of
- Peptides
- Insulins (Analogs)
- Oligonucleotides
- Proteins
- Applications
Peptides
- Although reversed phase has proven to be an acceptable technique, its selectivity shortcomings and enormous costs have urged the need for more efficient separation techniques.
- ZEOsphere® DRPs orthogonality leads to enhanced separation.
- Sharper peaks, faster retention, better selectivity. Significant yield improvement. Lower organic solvent consumption.
Insulins
- In crude insulins, differences in structures are very minimal. Presently used separation techniques like ionexchange and reversed phase lead to low production efficiency due to inadequate selectivity.
- Dual interaction ZEOsphere® DRP. Substantially increased selectivity. Higher yield and loadability. Enhanced productivity.
Oligonucleotides
- Synthetic oligonucleotides gain increasing importance in new therapeutic concepts.
- Standard used reversed phase chromatography shows insufficient and strongly retained separation, which leads to low yields and a subsequent increase in costs.
- ZEOsphere® DRP produces improved selectivity. Substantial higher yields. Unequaled efficiency.
- Column Packing Material for
- Analytical (HP) LC
- Preparative (HP) LC
- Supercritical fluid chromatography (SFC)
- Continuous chromatography
Technical Details & Test Data
- Faster Retention Time
Goserelin, Positive Charged Peptide
- Increased Selectivity
Goserelin, Positive Charged Peptide
- Higher Purity & Yield
- Goserelin, Positivity Charged Peptide
- Yield Versus Purity Ratio
- Process
- Purification of charged API currently processed via reversed phase and/or ion-exchange chromatography. The unique method of ZEOsphere® DRP (Doped Reversed Phase) is based on attraction-repulsion by merging a high performance reversed-phase with ion-exchange (anion or cation) material.
- ZEOsphere® DRP. Mixed mode. Spherical silica gel. Highly efficient and extremely powerful.
- Enhanced Loadability
