Products in Formulation & Processing Aids

TABULOSE® SC 611 is an efficient suspending agent for suspensions, emulsions and reconstituable suspensions. Features Hydrates quickly Co-processing ensures perfect stability to the three-dimensional gel formed upon hydration

TABULOSE® SC-591 F is a co-processed microcrystalline cellulose (MCC) and carboxymethylcellulose sSodium (CMC) that can be used as a stabilizer, suspending agent and thickener in a variety of food and beverage applications. Benefits Gluten-free Sugar-free Calorie reduction Fat reduction Features Water dispersible Stable over wide temperature and pH ranges Smooth, creamy texture

TABULOSE® SC 681 Colloidal Microcrystalline Cellulose is a co-processed microcrystalline cellulose (MCC) and carboxymethylcellulose sodium (CMC) that can be used as a stabilizer, suspending agent and thickener in a variety of food applications. Benefits Gluten-free Sugar-free Features Water dispersible Stable over wide temperature and pH ranges Smooth and creamy texture

POLYSORB® 85/70/00 Partially dehydrated sorbitol liquid is a plasticizer in soft capsules and orally dissolving films. It can be used in pharmaceutical dosage forms.POLYSORB® 85/70/00 is an aqueous solution of D-sorbitol and 1.4- sorbitans that has been developed by Roquette as a plasticizer for soft gelatine capsule applications. The advantage of this product in soft gels relates to its remarkable compatibility with gelatin that ensures no migration over time thereby preventing any defects like graining when crystallizing plasticizers are used or leaching phenomena either into the filler media or at the surface of the soft gel.

Tooth-friendly NEOSORB® XTAB 300S is a directly compressible sorbitol powder for very hard sugar-free tablets with high flavor load. Benefits Delivers a smooth, hard and uniform colored surface. Provides a clean, cooling effect. Does not produce acids or cause dental plaque or tooth decay. Nutritional benefits (maintenance of tooth mineralization, tooth-friendly generic EU claims) recognized by European regulations.

NEOSORB® BioPharma Low endotoxin grade sorbitol provides protein stabilization in your biopharmaceutical downstream applications. Known for its high water solubility, it is a proven formulation aid for biopharmaceuticals. Sorbitol is used as an excipient in over 35 commercial mAbs, therapeutic proteins and vaccines. Roquette's in process quality controls ensure a consistent supply of raw materials and excipients to help bring your biologics to life. Through our integrated supply chain and rigorous quality systems, we reduce the risks associated in biopharmaceutical manufacturing. NEOSORB® BioPharma is suitable for use in biopharmaceutical manufacturing and as an excipient for injectable dosage forms. Contact us today to talk about our multi-compendial materials - EP, JP, and USP.

NEOSORB® PF pyrogen-free sorbitol is used: as a carbohydrate source and osmotic diuretic agent in large-volume parenteral injectables as an isotonic agent for Rx injectables as an irrigating fluid for surgical procedures, to prevent intra- and extra-cellular dehydration

NEOSORB®70/70 B Sorbitol liquid crystallizing and non-crystallizing products are widely used excipients as vehicle in liquid dosage forms and as a humectant in semi solids. They can be used in various pharmaceutical and nutraceutical applications including lozenges, medicated confectionary, syrups, suspensions, creams and pastes. These NEOSORB® 70/70 B brand materials are part of a large family of Roquette polyol compounds containing sorbitol and other hydrogenated long chain oligomers and polymers. NEOSORB®70/70 B solutions can be used as substitutes for sucrose and meet organoleptic (natural sweetness) and health requirements (i.e they are sugar-free, low-calorie, do not induce dental caries, and may be advised for diabetics). These grades will differ by a difference of composition and concentration in sorbitol and other polyols.

NEOSORB® 70/70 is a versatile ingredient offering low calorie and sugar-free benefits, making it ideal for various applications where sweetness and reduced calorie content are desired. Its clear, colorless, and syrupy nature, along with its water solubility, allows for easy incorporation into formulations, providing a sweet flavor without the addition of sugar.

TACKIDEX® Potato dextrins provide a variety of benefits to the manufacturer and consumer as both an excipient and a nutrient. They are white to yellow powders obtained from maize, tapioca, and potato starch by heat treatment. These are ingredients for clinical nutrition and nutraceuticals. Dextrins are starch polymers derived through solid-state heating from partially hydrolysed starch. Dextrinization is a classical starch processing technology that makes partial or complete solubility possible. As an excipient, dextrins are a binder, filler, stabilizer,  suspending agent, and viscosifier. As a nutrient, it is a carbohydrate and fiber source. TACKIDEX® can be used in various oral dosage forms in both pharmaceutical and nutraceutical applications, including swallowable tablets, chewable tablets, effervescent tablets, lozenges, hard capsules, soft capsules, coatings, orally dissolving films, blends, granules, pellet premix, medicated confectionary, syrups, suspensions, and liquids.

PEARLITOL® PF is a pyrogen-free mannitol that is used for parenteral preparations and Rx injectables. Applications Osmotic diuretic agent in small and large volume parenteral injectables Isotonic agent and bulking agent for freeze-dried powder for Rx injection or infusion Pharmaceutical API used to reduce elevated pressure in the brain (cerebral oedema) and in the eyes (note: production has to comply with the internationally accepted GMP standards)

LYCADEX® PF is a pyrogen-free dextrose monohydrate that can be used: as isotonic agent in Rx excipients and in injectable applications including large volume parenteral, total parenteral nutrition as a carbohydrate source and osmotic agent for hemodialysis and peritoneal dialysis

NEOSORB® XTAB 300S is a directly compressible sorbitol powder that can be used for very hard, sugar-free tablets with high flavor load. Benefits Delivers a smooth, hard and uniform colored surface Provides a clean, cooling effect Does not produce acids or cause dental plaque or tooth decay Nutritional benefits (maintenance of tooth mineralization, tooth-friendly generic EU claims) recognized by European regulations Features Non-cariogenic Sugar-free

STEPANQUAT® 50, benzalkonium chloride solutions, stand as a reliable choice for broad-spectrum preservation in personal care and pharmaceutical products. This clear liquid, maintaining its clarity at 25°C, is especially suitable for applications like eye contact lens solutions and topical antiseptics.

STEPANQUAT® 65, benzalkonium chloride solutions, stand as a reliable choice for broad-spectrum preservation in personal care and pharmaceutical products. This clear liquid, maintaining its clarity at 25°C, is especially suitable for applications like eye contact lens solutions and topical antiseptics.

SILFAR® S 188 is a 100% silicone antifoam agent that has been specifically formulated for use in the pharmaceutical and food processing industries. It functions by acting as an antifoam agent, effectively preventing or alleviating flatulence in the digestive system. Additionally, it forms a protective lining on various surfaces, such as the gastric mucous membrane, providing additional benefits.

SILFAR® 350 is a polydimethylsiloxane derived from the hydrolysis and polycondensation of dichlorodimethylsilane and chlorotrimethylsilane. Its degree of polymerization (n) is adjusted to achieve a mean kinematic viscosity of 350 mm²/s at 25°C. This versatile product finds application in both the pharmaceutical and food sectors. In the pharmaceutical industry, it is commonly used in antiflatulence and antacid preparations.

SILFAR® E 1049 is a silicone fluid emulsion specifically formulated for a wide range of applications, including those in the food and pharmaceutical industries. It is composed of components that meet the necessary standards outlined in the relevant EP and USP monographs. SILFAR® E 1049 can be utilized as an excipient in pharmaceutical products, although it cannot be used as an active pharmaceutical ingredient.

SILFAR® S 184 is a 100% silicone antifoam agent specially designed for the pharmaceutical and food processing industries. It fully adheres to the specifications outlined in the "Simeticone (EP)" and "Simethicone (USP)" monographs. Produced under cGMP guidelines, SILFAR® S 184 is suitable for use as an active pharmaceutical ingredient (API), particularly in antiflatulence and antacid preparations.

SILFAR® SE 4 is a silicone antifoam emulsion that finds its use in the food and pharmaceutical sectors, as well as in fermentation processes and agrochemical formulations. It serves as an effective antifoam agent in various stages, including fermentation and downstream processes like active ingredient extraction and solvent recovery, where compliance with USP and EP standards is necessary.

SILFAR® SE 88 is a silicone antifoam emulsion suitable for various industries such as food, pharmaceuticals, fermentation processes, and agrochemical formulations. It is specifically designed for European use as a processing aid in food production, based on E 900. It is important for the food manufacturer to ensure that only minimal traces of the product are present in the final food, as per the necessary regulations.

HDK® N20 Pharma is a synthetic, hydrophilic, amorphous silica powder produced via flame hydrolysis. It is a white, high-purity colloidal powder that enhances the flow of powders and serves as a glidant for tableting processes. Additionally, HDK® N20 Pharma acts as a thickener for liquid pharmaceutical products. Furthermore, HDK® N20 Pharma undergoes testing according to the pharmacopeias EP and USP/NF standards.

SILFAR® 100 is a polydimethylsiloxane derived from the hydrolysis and polycondensation of dichlorodimethylsilane and chlorotrimethylsilane. Its degree of polymerization (n) is adjusted to achieve a mean kinematic viscosity of 100 mm²/s at 25°C. This product finds primary application in the pharmaceutical sector, particularly as a fundamental raw material in pharmaceutical formulations.

SILFAR® 1000 is a polydimethylsiloxane produced through the hydrolysis and polycondensation of dichlorodimethylsilane and chlorotrimethylsilane. Its degree of polymerization (n) is adjusted to achieve a mean kinematic viscosity of 1000 mm²/s at 25°C. This versatile product finds application in both the pharmaceutical and food sectors. In the pharmaceutical industry, it is commonly used in antiflatulence and antacid preparations.

HDK® N20 P Pharma is a synthetic, hydrophilic, amorphous silica powder produced via flame hydrolysis. It is a white, high-purity colloidal powder. This product serves as a glidant for tableting, effectively improving the flow of powders. Furthermore, HDK® N20 P Pharma undergoes testing according to the EP and USP/NF standards.

CAVAQ10® CoQ10 Complex is a highly bioavailable coenzyme Q10 powder with improved dispersibility in water. This product itself is not soluble in water and has low bioavailability. WACKER offers an excellent solution for increasing the bioavailability of hydrophobic health-promoting ingredients through complexation with cyclodextrins. CAVAQ10® CoQ10 Complex is an inclusion complex of natural ubiquinone with CAVAMAX® W8 gamma-cyclodextrin. As a powerful antioxidant, it brings a wide range of health benefits for various functional food and dietary supplement applications.

Evonik Tri-n-Propyl Orthoformate (TNPOF) is extensively employed in the synthesis of active pharmaceutical ingredients and serves as water-trapping agents or in the creation of specialized esters. These orthoesters are not manufactured under GMP (Good Manufacturing Practices) but adhere to exceptionally stringent specification parameters that can be customized to meet specific customer needs.

Evonik Triethyl Orthoacetate (TEOA) is extensively employed in the synthesis of active pharmaceutical ingredients and serves as water-trapping agents or in the creation of specialized esters. These orthoesters are not manufactured under GMP (Good Manufacturing Practices) but adhere to exceptionally stringent specification parameters that can be customized to meet specific customer needs.

ZEOFREE® 600 LA is a synthetic calcium silicate produced through a precipitation process. This multifunctional calcium silicate is an outstanding soft-focus agent that also improves flow properties and prevents caking in moisture-sensitive mixtures. Calcium silicate made by Evonik combines an exceptionally high absorption capacity with a very pleasant, silky skin feel.

SIPERNAT® 380 is an ultra-fine particle size precipitated silica with applicability in many markets. Its particle size and distribution are based on a unique process that results in a variety of effects. SIPERNAT® 380 provides excellent free flow and anti-caking properties in powdered foods.

T-Det® PEG 6000 F is a 100% active polyethylene glycol with an average molecular weight of 6000. It is used to modify therapeutic proteins and peptides to increase their solubility. It appears as white to off-white flakes. T-Det® PEG 6000 F is an effective emulsifier, dispersant, and solubilizer used in a wide range of applications, including personal care products, pharmaceuticals, and industrial formulations. It can also be used as a viscosity modifier, lubricant, and plasticizer.

T-Det® PEG 1200 is a polyethylene glycol with a molecular weight of 1200. It is a nonionic surfactant commonly used as a thickening, wetting, and emulsifying agent in various industries, such as personal care, pharmaceuticals, and food. It is known for its ability to mix well with both water- and oil-based substances, making it a versatile ingredient in many formulations.

ADM Sodium Citrate Dihydrate Powder (USP-NF/FCC) (042440) is derived from citric acid and is available in a free-flowing, colorless powder form. It is odorless and freely soluble in water, but insoluble in alcohol. Sodium citrate dihydrate is the most widely used emulsifying salt in sliced processed cheese products. It is commonly used as a buffering agent in combination with citric acid to provide the precise pH control required in many food and beverage applications. In meat products, it is used as an anticoagulant for fresh livestock blood and as a curing accelerator. The detergent-building and rapid biodegradability characteristics of sodium citrate enable its use as an environmentally acceptable phosphate substitute in a large variety of household cleaning products.

ADM Sodium Citrate Dihydrate Granular (USP-NF/FCC) (042410) is derived from citric acid and is available in a free-flowing, colorless granular form. It is odorless and freely soluble in water, but insoluble in alcohol. Sodium citrate dihydrate is the most widely used emulsifying salt in sliced processed cheese products. It is commonly used as a buffering agent in combination with citric acid to provide the precise pH control required in many food and beverage applications. In meat products, it is used as an anticoagulant for fresh livestock blood and as a curing accelerator. The detergent-building and rapid biodegradability characteristics of sodium citrate enable its use as an environmentally acceptable phosphate substitute in a large variety of household cleaning products.

ADM Sodium Citrate Dihydrate Fine Granular (USP-NF/FCC) (042420) is derived from citric acid and is available in a free-flowing, colorless granular form. It is odorless and freely soluble in water, but insoluble in alcohol. Sodium citrate dihydrate is the most widely used emulsifying salt in sliced processed cheese products. It is commonly used as a buffering agent in combination with citric acid to provide the precise pH control required in many food and beverage applications. In meat products, it is used as an anticoagulant for fresh livestock blood and as a curing accelerator. The detergent-building and rapid biodegradability characteristics of sodium citrate enable its use as an environmentally acceptable phosphate substitute in a large variety of household cleaning products.

Dissolvine NA2-P is a ethylenediaminetetraacetic acid (EDTA), disodium salt.