Knowde Enhanced TDS
Identification & Functionality
- Chemical Family
- Chemical Name
- Base Chemicals Functions
- Pharma & Nutraceuticals Functions
- CAS No.
- 98-59-9
- EC No.
- 202-684-8
Applications & Uses
- Applications
- Applicable Processes
- Base Chemicals End Uses
- Application
PTSC is an intermediate in chemical and pharmaceutical synthesis. Among others it is an activation agent in the synthesis of organic compounds. One major application of PTSC is the tosylation of alcohols in order to activate the group for conversion at a later step in the synthesis. Through the use of PTSC an alcohol can be converted into an excellent leaving group, as depicted in below schema:
R-OH + TsCl → R-OTs + HCl
R-OTs + NH3 → R-NH2 + HOTs
NH3 is taken as example but it can be done with any organic nucleophile.
PTSC is also used to convert carboxylic acids into phenolic esters through the use of the weak nucleophiles like phenols.
Many pharmaceuticals are prepared with PTSC as activating agent as for example:
• Flupentixol (psychiatric drug)
• Thiometon (pesticide)
• Deltamethrine (pesticide)
• Diboc (protecting agent)
• Cefotaxime (antibiotic)
• MDMA (psychiatric drug)
Properties
- Appearance
- White Crystalline Powder*
- Physical Properties
- Typical Properties
- Toxicological information
Acute toxicity (oral): LD50 rat > 4680 mg/kg Genotoxicity (Ames test): not mutagenic Biotic degradation: readily biodegradable - Notes
*Little colored spots can be found on the surface of the powder due to moisture condensation.
| Value | Units | Test Method / Conditions | |
| Apparent Bulk Density | 660 - 730 | kg/m3 | — |
| Boiling Point (1.33 Kpa) | 135.5 | °C | — |
| Flash Point (Closed Cup) | 128 | °C | — |
| Value | Units | Test Method / Conditions | |
| Active Content | min. 99.5 | % | — |
| Water Content | max. 0.1 | % | — |
| Crystallisation Point | min. 66.9 | °C | — |
| Colour (25 % Solution in Acetone) | max. 40 | Pt/Co | — |
| P-Toluenesulfonic Acid | max. 0.2% | % | — |
| O-Toluenesulfonylchloride | max. 0.3% | % | — |
Regulatory & Compliance
- Certifications & Compliance
Packaging & Availability
- Packaging Type
- Packaging
• 25 kg polyethylene drums, 24 on a pallet.
• 100 kg polyethylene drums, 4 on a pallet.
Storage & Handling
- Storage
Store in a cool dry place.