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<p><span style="color: rgb(80, 80, 80);">Biocogent, LLC utilizes pioneering technology in research, development, and manufacturing to provide innovative, value-driven functional ingredients and services to its customers in the personal care and cosmetic industries. Rooted in biotechnology, Biocogent utilizes more than 100 years of cumulative expertise in skin, cell and tissue culture and biochemistry. The company deploys the science behind its platform technologies to treat the critical points of beauty including anti-aging, skin renewal, moisturization, skin protection, and detoxification -- all essential for the restoration, revitalization, and maintenance of healthy and youthful skin.</span></p>

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A marine-derived ferment of Sargassum vulgare. Rich in bioactive phlorotannins that rejuvenate and protect through the stimulation of the skin's natural DNA repair processes.

DermalRx® FSE (R10111)

Grandiciin® is a plant-dervied active produced from Epimedium sagittatum, rich in a beneficial mix of prenylated flavonoids including icariin and epimedins.

Pleiotanicals® Grandiciin® (R10124)

Volpura® EP is an Echinacea purpurea extract to address the signs of aging by supporting the skin’s natural plumping processes.

Pleiotanicals® Volpura® EP (R10098)

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HEDI® products has resulted in unique ingredients that provide benefits and value previously impossible to achieve. Stable and infinitely cold-dilutable aqueous products containing very high levels of hydrophobic (oils, butters, non-polar molecules, silicones, etc.) are possible. And, because water remains free and unbound, these products are pumpable, often sprayable, spreadable and easy to handle.
The homogeneity of specific particle size and distribution achieved through HEDI® technology provides a level of formula aesthetics, performance, and functionality not possible by simply adding individual components in situ. HEDI® products are easy to handle, require only simple mixing without heat, and provides significant savings in time during product development and in manufacturing. HEDI® products are excellent choices for a wide range of applications: moisturizing lotions and creams, skin toners, serums, sunscreens, barrier repair products (after shave, post-laser, after-sun), sensitive skin formulas, baby care products, wet wipes, hair conditioners, and many others.

HEDI

DermalRx® products are manufactured utilizing the latest extraction, fermentation and bio-conversion technologies and are particularly appropriated for maintenance, treatment and corrective skin care systems.

DermalRx

 



Biocogent's Pleiotanicals® are high-potency plant-derived pleiotropic (multi-functional) active ingredients. These products are derived from whole plant or specific plant parts (flowers, roots, stems). Utilizing specialized and proprietary extraction techniques, such as clean supercritical fluids and cell rupture extraction and purification, active biomolecules are targeted, gently and efficiently extracted, purified and concentrated for greater activity and stability.


Pleiotanicals

 



Biocogent's Advanced Solutions are ingredients based on unique combinations of biopolymers and active ingredients that provide distinctive benefits and functionality. These products are value driven, providing easy-to-formulate, and proven functional benefits, at a value.


Advanced Solutions

Cogesomes represent a breakthrough technology to effectively deliver the potent beneficial effects of active ingredients to the skin. Biocogent scientists designed and developed a novel and proprietary liposome formulation that encapsulates the active in a manner not previously seen in the skin care community.

Cogesome

DermalRx® HydroSeal (R10067) is a yeast-derived oligopeptide that fortifies the skin barrier functions to restore moisture retention. Clinical testing demonstrates that DermalRx® HydroSeal has impressive moisturizing and anti-wrinkle effects in four weeks. Ideal for applications in anti-aging, anti-wrinkle, moisturization, and skin repair products, DermalRx® HydroSeal rebuilds cell-to-cell junctions for a more compact and less permeable stratum corneum, reducing transepidermal water loss (TEWL) and improving skin hydration. DermalRx® HydroSeal is produced using biofermentation with a proprietary Saccharomyces cerevisiae strain to improve the integrity of the skin barrier for skin moisturization and protection from excessive water loss.

DermalRx® HydroSeal (R10067)

Cogesome® RL (R10115) is a novel and proprietary pro-liposome formulation that encapsulates retinol (vitamin A) for superior penetration into the skin, improved stability, and optimal miscibility in aqueous systems. The power of retinol is undisputed, accelerating epidermal renewal and enhancing collagen and hyaluronic acid production to reduce the appearance of fine lines, wrinkles, and other signs of aging and improve the skin’s overall appearance. Properly managed retinol is one of the skin’s best supporters, contributing to a healthy glow and youthful appearance.Ex vivo data demonstrate how Cogesome® RL rapidly penetrates the skin, enhancing the penetration and delivery of retinol from the skin’s surface deep into the skin to maximize efficacy. Cogesome® RL significantly reduces biofilm-forming skin resident Cutibacterium acnes, a microbial culprit of blemish flare-ups and skin inflammation. Cogesome® RL is well suited for applications in anti-aging, anti-wrinkle, and anti-blemish formulas, skin exfoliating and resurfacing products, and regimens targeting sun damage and hyperpigmentation.

Cogesome® RL (R10115)

Pleiotanicals® Holy Basil OSE (R10104) is a proprietary extract of Ocimum sanctum (a plant used in Ayurvedic medicine) for pollution protection and aging prevention in the skin. Holy Basil OSE contains key active molecules, including polyphenols and pentacyclic triterpenoids, that protect against environmental pollution with anti-aging benefits. Holy Basil OSE is ideal for anti-aging, anti-wrinkle, de-stressing, and pollution/UV protection regimens, as well as soothing, calming products for sensitive skin.

 

Holy Basil OSE reduces a suite of inflammatory mediators in the skin typically induced by exposure to airborne particular matter (PM2.5). Holy Basil OSE protects the extracellular matrix (ECM, the structural foundation of the skin) against damaging oxidative, proteolytic, and inflammatory stress while also modulating collagen and other genes fundamental for ECM structure and integrity.


Pleiotanicals® Holy Basil OSE (R10104)

DermalRx® LuShield™ (R10056) is a proprietary extract of the fragrant flowering Osmanthus fragrans shrub that delivers anti-aging effects through senolytic, antioxidant, anti-inflammatory, and protective activities. DermalRx® LuShield™ addresses cellular senescence due to environmental and dietary stressors while also protecting collagen and the extracellular matrix (ECM, the structural foundation of the skin) from the damaging effects of advanced glycation end-products (AGEs), UV radiation, free radicals, and pollution (PM2.5). DermalRx® LuShield™ protects the skin to facilitate the natural repair, rebuilding, and restructuring of skin and skin matrices for a healthy and youthful appearance.  

DermalRx® LuShield™ (R10056)

HEDI® Shea Butter E/DU (R10028) is a unique water-based microdispersion of shea butter with dimethicone, urea, and vitamin E. Dimethicone is a skin protectant when formulated at levels of 5% or greater, while urea provides humectancy and helps to condition the skin. Vitamin E shields the skin from oxidation and free radicals.The triglycerides (fat) in shea butter are derived mainly from stearic acid and oleic acid. HEDI® Shea Butter E/DU is an excellent emollient, conditioner, and moisturizer that revitalizes dull, dry skin and promotes skin renewal. Applications for HEDI® Shea Butter E/DU include moisturizing treatments for very dry, rough, and cracked skin, skincare products for sensitive skin, and skin, scalp, and hair care conditioning formulas. HEDI® Shea Butter E/DU can be used in many care products, such as moisturizing creams and emulsions, sunscreens, lip gloss, makeup primers, facial masks, sunless tanning products, hair conditioners, and soaps.USP dimethicone enables OTC Skin Protectant claims when formulating with HEDI® Shea Butter E/DU at concentrations ≥ 5%.HEDI® products are stable ingredient blends of aqueous and oil-based materials made using a unique manufacturing process. HEDI® products are ultra-concentrated homogeneous constructs that are infinitely dilutable in aqueous systems. HEDI® products have superior aesthetics while simplifying formulation and manufacturing processes and enhancing the delivery of active ingredients in the formula. HEDI® products can be adjusted to achieve a consistency that is milk-like (pourable and even sprayable), creamy, or paste-like. Tactile properties can be light and silky or velvety and more occlusive. HEDI® products streamline manufacturing processes for time, energy, and cost savings by avoiding additional heating, melting, and mixing steps. HEDI® products are amenable to cold processes and do not require surfactants or emulsifiers.HEDI® products have properties similar to the skin barrier, promoting skin permeability and facilitating delivery through the lipid-rich, waterproof stratum corneum. Finished products have a better feel and provide superior surface coverage when compared to traditionally formulated butters and oils.

HEDI® Shea Butter E/DU (R10028)

Pleiotanicals® Volpura® EP (R10098) is an Echinacea purpurea extract to address the signs of aging by supporting the skin’s natural plumping processes. Volpura® EP activates adipogenesis (fat production) within the skin to combat the appearance of wrinkles and sagging from deep within the tissue. Volpura® EP restores fuller, youthful-looking skin by activating an adipogenic modulator that increases the number and size of fat-producing cells. Clinical studies demonstrate that Volpura® EP improves skin mechanical properties with volumizing, anti-wrinkle activity reported after use on the face and hands for 12 weeks. Volpura® EP is recommended for anti-wrinkle, anti-aging, firming, plumping, topical contouring, and volumizing products, as well as regimens to address age-related lipoatrophic disorders.


DermalRx® CKW (R10091) is a plant-derived combinatorial curcuminoid extract that potently and dose-dependently modulates excess sebum production by inhibiting type I and type II 5α-reductase. Clinical evaluation showed significant reductions in sebum production and a visible decrease in facial sheen. DermalRx® CKW is ideal for sebum-regulating products for skin and hair applications, as well as anti-blemish and pore-minimizing formulations.

DermalRx® CKW (R10091)

Tellirictin® (R10047) is a proprietary clove flower extract containing natural gallate-based pleiotropic compounds (tellimagrandin I and casuarictin) for multi-functional anti-aging performance. Tellirictin® addresses the many signs of aging by delivering brightening, anti-wrinkle, and moisturizing activities, while also protecting the skin from oxidative, inflammatory, proteolytic, and environmental stresses. Applications of Tellirictin® include anti-aging, anti-wrinkle, and skin-brightening regimens, soothing and calming products for sensitive skin, and pre- and post-sun care.

 

Tellirictin® prevents excessive melanin production to combat hyperpigmentation by inhibiting tyrosinase activity as efficiently as beta-arbutin. Tellirictin® protects collagen and other components of the extracellular matrix (ECM, the structural foundation of the skin) from damaging enzymes (MMPs and elastases) associated with environmental stressors such as environmental pollution and UV (sun) exposure. Tellirictin® modulates microRNAs involved in the beneficial regulation of DNA repair, barrier protection, and anti-inflammatory pathways. 


Pleiotanicals® Tellirictin® (R10047)

Advanced Solutions MariMoist® KPF (R10097) is a sustainable marine biopolymer derived from Chondrus crispus aquatic plants with bio-derived high molecular weight hyaluronic acid (HA), a glycosaminoglycan that is an important natural component of skin. Referred to as the “aloe of the ocean,” MariMoist® KPF is a water-soluble, viscous, hydrocolloid-flowing gel with the highest standards of consistency, quality, and purity.

 

MariMoist® KPF provides water delivery and a unique textural sensation, improving the aesthetic and tactile properties of finished products while helping to build “body” and impart a rich, luxurious feel. MariMoist® KPF has been demonstrated to bind and deliver water for optimal hydration of the skin, scalp, and hair. Acting as a humectant, MariMoist® KPF is an emollient liquid that instantly moisturizes and softens dry skin.

 

Applications for MariMoist® KPF include an emollient and hydrator in skin and hair products and a formulation aid or aesthetic modifier of product viscosity and body. MariMoist® KPF is an excellent base for formulations.


Advanced Solutions MariMoist® KPF (R10097)

Biocogent LLC

Biocogent, LLC utilizes pioneering technology in research, development, and manufacturing to provide innovative, value-driven functional ingredients and services to its customers in the personal care 

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