Biocogent LLC

Pleiotanicals® Holy Basil OSP (R10110) is a proprietary extract of Ocimum sanctum (a plant used in Ayurvedic medicine) for pollution protection and aging prevention in the skin. Holy Basil OSP contains key active molecules, including polyphenols and pentacyclic triterpenoids, that protect against environmental pollution with anti-aging benefits. Holy Basil OSP is ideal for anti-aging, anti-wrinkle, de-stressing, and pollution/UV protection regimens, as well as soothing, calming products for sensitive skin.   Holy Basil OSP reduces a suite of inflammatory mediators in the skin typically induced by exposure to airborne particular matter (PM2.5). Holy Basil OSP protects the extracellular matrix (ECM, the structural foundation of the skin) against damaging oxidative, proteolytic, and inflammatory stress while also modulating collagen and other genes fundamental for ECM structure and integrity.

HEDI® Avocado (R10089) is a unique combination of avocado butter with plant-derived squalane, radish seed extract, and vitamin E in a silicone-free microdispersion carrying more than 30% hydrophobe. Avocado Butter is an occlusive moisturizer to lock in moisture, rich in essential fatty acids and antioxidants. Squalane and radish seed extract act as emollients to help to soothe and soften, and improve skin barrier function. Vitamin E shields from oxidation and free radicals. Applications for HEDI® Avocado include moisturizing treatments for very dry, rough, and cracked skin, skincare products for sensitive skin, and skin, scalp, and hair care conditioning formulas.HEDI® products are stable ingredient blends of aqueous and oil-based materials made using a unique manufacturing process. HEDI® products are ultra-concentrated homogeneous constructs that are infinitely dilutable in aqueous systems. HEDI® products have superior aesthetics while simplifying formulation and manufacturing processes and enhancing the delivery of active ingredients in the formula. HEDI® products can be adjusted to achieve a consistency that is milk-like (pourable and even sprayable), creamy, or paste-like. Tactile properties can be light and silky or velvety and more occlusive. HEDI® products streamline manufacturing processes for time, energy, and cost savings by avoiding additional heating, melting, and mixing steps. HEDI® products are amenable to cold processes and do not require surfactants or emulsifiers.HEDI® products have properties similar to the skin barrier, promoting skin permeability and facilitating delivery through the lipid-rich, waterproof stratum corneum. Finished products have a better feel and provide superior surface coverage when compared to traditionally formulated butters and oils.

HEDI® Shea Butter E/DU (R10028) is a unique water-based microdispersion of shea butter with dimethicone, urea, and vitamin E. Dimethicone is a skin protectant when formulated at levels of 5% or greater, while urea provides humectancy and helps to condition the skin. Vitamin E shields the skin from oxidation and free radicals.The triglycerides (fat) in shea butter are derived mainly from stearic acid and oleic acid. HEDI® Shea Butter E/DU is an excellent emollient, conditioner, and moisturizer that revitalizes dull, dry skin and promotes skin renewal. Applications for HEDI® Shea Butter E/DU include moisturizing treatments for very dry, rough, and cracked skin, skincare products for sensitive skin, and skin, scalp, and hair care conditioning formulas. HEDI® Shea Butter E/DU can be used in many care products, such as moisturizing creams and emulsions, sunscreens, lip gloss, makeup primers, facial masks, sunless tanning products, hair conditioners, and soaps.USP dimethicone enables OTC Skin Protectant claims when formulating with HEDI® Shea Butter E/DU at concentrations ≥ 5%.HEDI® products are stable ingredient blends of aqueous and oil-based materials made using a unique manufacturing process. HEDI® products are ultra-concentrated homogeneous constructs that are infinitely dilutable in aqueous systems. HEDI® products have superior aesthetics while simplifying formulation and manufacturing processes and enhancing the delivery of active ingredients in the formula. HEDI® products can be adjusted to achieve a consistency that is milk-like (pourable and even sprayable), creamy, or paste-like. Tactile properties can be light and silky or velvety and more occlusive. HEDI® products streamline manufacturing processes for time, energy, and cost savings by avoiding additional heating, melting, and mixing steps. HEDI® products are amenable to cold processes and do not require surfactants or emulsifiers.HEDI® products have properties similar to the skin barrier, promoting skin permeability and facilitating delivery through the lipid-rich, waterproof stratum corneum. Finished products have a better feel and provide superior surface coverage when compared to traditionally formulated butters and oils.

DermalRx® SRC-R (R10099) is a yeast-derived oligopeptide that promotes skin renewal by stimulating natural exfoliation via gentle and selective desquamation. Clinical testing demonstrates that DermalRx® SRC-R enhances exfoliation to reduce skin roughness and improve the appearance of wrinkles in four weeks. DermalRx® SRC-R gently loosens coarse keratinized cells at the surface, delivering results for applications in anti-aging, anti-wrinkle, anti-blemish, skin brightening, and exfoliation products. DermalRx® SRC-R is clinically demonstrated to restore skin texture and radiance with documented improvements in the appearance of hyperpigmentation, wrinkles, and other signs of aging. DermalRx® SRC-R is a selective exfoliant for safe, effective skin renewal.

DermalRx® FSE (R10111) is a marine bioferment produced from Sargassum vulgare for DNA protection and repair in sun-exposed skin. Rich in bioactive phlorotannins, DermalRx® FSE stimulates the skin’s natural DNA repair process through nucleotide excision repair (NER). Ex vivo studies demonstrate DermalRx® FSE’s DNA protective and reparative effects after UV exposure. DermalRx® FSE also provides strong anti-pollution activity, protecting the skin from damaging oxidation and inflammation. DermalRx® FSE is ideal for anti-aging, de-stressing, soothing and calming, and pre- and post-sun care products.

Pleiotanicals® Volpura® EP (R10098) is an Echinacea purpurea extract to address the signs of aging by supporting the skin’s natural plumping processes. Volpura® EP activates adipogenesis (fat production) within the skin to combat the appearance of wrinkles and sagging from deep within the tissue. Volpura® EP restores fuller, youthful-looking skin by activating an adipogenic modulator that increases the number and size of fat-producing cells. Clinical studies demonstrate that Volpura® EP improves skin mechanical properties with volumizing, anti-wrinkle activity reported after use on the face and hands for 12 weeks. Volpura® EP is recommended for anti-wrinkle, anti-aging, firming, plumping, topical contouring, and volumizing products, as well as regimens to address age-related lipoatrophic disorders.

Cogesome® SA (R10126) is a novel and proprietary liposome formulation that encapsulates salicylic acid (SA) for improved long-term stability and pH to near physiological levels, optimal miscibility in aqueous and glycolic systems, and superior penetration into the skin. Cogesome® SA is well suited for formulas to address blemished skin, including spot treatments, cleansing, and clarifying products, and overnight resurfacing treatments, as well as other skin and hair formulas.Cogesome® SA supports superior skin penetration properties without the irritation associated with traditional salicylic acid. Cogesome® SA is stable and soluble in water for easy formulation in aqueous-based formulation systems. Cogesome® SA is a completely liposome-encapsulated salicylic acid with high miscibility and a pH of 6-7.4, close to physiological pH. As such, the incorporation of salicylic acid by Cogesome® SA does not significantly impact the pH of the final formulation. Cogesome® SA is a high-technology solution for blemish-prone skin.

Pleiotanicals® Scavenox® GTE (R10025) is a highly stable green tea extract with epigallocatechin gallate (EGCG) for long-term antioxidant, anti-inflammatory, and skin-brightening activity. Applications for Scavenox® GTE include anti-aging and anti-blemish regimens, skin-brightening and skin tone-balancing systems, and soothing and calming products for sensitive skin.   Scavenox® GTE protects the skin from oxidative stress with the demonstrated ability to prevent UV-induced lipid peroxidation and scavenging of singlet oxygen. Scavenox® GTE also inhibits inflammatory and proteolytic (MMPs and elastase) damage for protection against UV radiation, pollution, and other environmental stressors. These activities offer skin protection and renewal by preserving collagen and other components of the extracellular matrix (ECM, the structural foundation of the skin). Scavenox® GTE prevents excessive melanin production to combat hyperpigmentation by inhibiting tyrosinase activity.

Advanced Solutions MariMoist® KPF (R10097) is a sustainable marine biopolymer derived from Chondrus crispus aquatic plants with bio-derived high molecular weight hyaluronic acid (HA), a glycosaminoglycan that is an important natural component of skin. Referred to as the “aloe of the ocean,” MariMoist® KPF is a water-soluble, viscous, hydrocolloid-flowing gel with the highest standards of consistency, quality, and purity.   MariMoist® KPF provides water delivery and a unique textural sensation, improving the aesthetic and tactile properties of finished products while helping to build “body” and impart a rich, luxurious feel. MariMoist® KPF has been demonstrated to bind and deliver water for optimal hydration of the skin, scalp, and hair. Acting as a humectant, MariMoist® KPF is an emollient liquid that instantly moisturizes and softens dry skin.   Applications for MariMoist® KPF include an emollient and hydrator in skin and hair products and a formulation aid or aesthetic modifier of product viscosity and body. MariMoist® KPF is an excellent base for formulations.