Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- CAS No.
- 497-30-3
- EC No.
- 207-843-5
- Product Families
Features & Benefits
- Benefit Claims
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Product Highlights
Known as a “longevity vitamin” by Dr. Bruce Ames, L-ergothioneine (L-ET) is an amino acid with potent antioxidant properties that is found in foods such as mushrooms, beans, and chicken and pork liver. Human cells express a highly specific transport protein called the ergothioneine transporter (ETT), leading many researchers to investigate its importance to several areas of human health. ErgoActive® is a sustainable source of highly pure L-ergothioneine without reliance on intensive farming or inconsistent harvests.
- Advantages of ErgoActive®
- Demonstrated in a first-of-kind in vitro study to support telomeres
- US FDA no objection to notification of self-armed GRAS (GRN No. 734)
- Sustainably produced using a proprietary fermentation process
- GMO-free, vegan, and kosher certified
- Water-soluble powder, and neutral in taste, color and odor
Applications & Uses
- Applications
- Benefit Areas
- Mitochondrial Function
- Antioxidant Support
- L-Ergothioneine is concentrated in mitochondria and protects mitochondrial DNA from oxidative damage.
- Cognitive Health
- Age-associated declines in blood L-ET levels may be associated with a risk of mild cognitive impairment (MCI) in healthy elderly.
- The consumption of mushrooms has also been inversely associated with MCI.
- Telomere Support
- Healthy Aging
- Under oxidative conditions ErgoActive® reduced the telomere shortening rate by 27-52% at 4 weeks compared to cells that were not treated with L-ET.
- Skin Health
- Skin cells express the ETT, which allow them to take up, accumulate, and use L-ET to protect against oxidative stress.
- Ergothioneine inhibits UV-induced reactive oxygen species (ROS) production and subsequent skin cell damage.
Properties
- Physical Form
- Solubility
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Clinical Studies
Cognition Support
Increasing age has been associated with decreasing blood levels of ergothioneine and a greater incidence of mild cognitive impairment (MCI).- In a 2016 study, researchers found that blood ergothioneine levels in elderly declined significantly (P < 0.01, r = -0.2159) beyond 60 years of age.
- This decrease in ergothioneine may indicate that low ergothioneine is a risk factor for neurodegeneration in the elderly.
- The consumption of mushrooms has also been inversely associated with MCI.
Ergothioneine and Telomeres
Shortened telomeres are associated with aging and age-related diseases, and oxidative stress is thought to be a major contributor to telomere shortening.
- In a recent in vitro study, ergothioneine preserved telomere length and reduced the rate of telomere shortening under oxidative stress conditions, suggesting ergothioneine as beneficial for healthy aging.