BergacynFF®

Identification & Functionality

Active Component

Cynaropicrin,

Flavonoids,

Polyphenols,

Sesquiterpenes

Ingredient Name

Bergamot Cynara Extract Blend

Ingredient Origin

Natural Origin,

Plant Origin

Food Ingredients Functions

Supplement

Pharma & Nutraceuticals Functions

Phytochemical,

Supplement

Country of Origin

Calabria, Italy

Ingredients

Bergamot Extract, Cynara Extract

Technologies

Food Ingredients,

Pharmaceuticals & Nutraceuticals

Product Families

Pharmaceuticals & Nutraceuticals — Nutraceuticals & Supplements

Phytochemicals & Plant Extracts,

Supplements & Functional Ingredients

Food Ingredients — Nutrition & Fortification

Functional Ingredients,

Phytochemicals

Features & Benefits

Benefit Claims (Health)

Anti-Inflammatory,

Hepatoprotection,

Improve Liver Functions,

Maintain Healthy Liver,

Promotes Healthy Uric Acid Levels,

Promotes Lipid Metabolism,

Regulates Metabolism,

Supports Cardiovascular health,

Supports Endothelial Function,

Vasoprotective,

Weight Management

Labeling Claims

Clean Label,

Excipient-Free,

GMO-free,

Irradiation-free,

Naturally Derived,

Plant-Based,

Solvent-free

Food Ingredients Features

Antioxidant Properties,

Excellent Bioavailability,

Free Flowing,

Prebiotic Effects

Product Highlights

• BergacynFF® is a patented, clinically-studied, solvent-free Bergamot citrus and Cynara leaf extract blend. It promotes liver and cardiometabolic health and supports healthy weight management by protecting against fat storage and transport dysfunction.
• BergacynFF®’s polyphenol, sesquiterpene, and citrus pectin bioactives synergistically combine to deliver enhanced bioavailability of multiple plant actives.
• Poor eating and lifestyle habits, aging, and significant hormonal shifts, like menopause, challenge proper blood sugar control and insulin output.These changes overwhelm/remodel the body’s normal storage of fats, regulation of cytokines, and balance of oxidative stress – particularly in the liver.
• Ultimately, healthy fat transport is disturbed and the vascular system, liver, and abdominally centered tissue become reserve sites for the deposit of inflammatory fats.
• Mildly increased uric acid (UA) levels appear to mediate early fat congestion changes in the liver. Among Bergacyn’s multitargeted actions, it’s support of balanced UA levels in modulating lipid traffic in the liver is trendsetting.

Applications & Uses

Markets

Healthcare & Pharma

Applications

Healthcare & Pharma — Drug Delivery & Care Solutions

Oral

Dosage Form

Capsules,

Powder & Powder Blends,

Soft Gels

Properties

Physical Form

Powder

Solubility

Water Soluble

Appearance

Powder

Flavor

Characteristic

Odor

Characteristic

Note

*Secondary Analysis at 6 weeks; Note: approx, 6/9 lbs. lost in 1st 6 weeks

Technical Details & Test Data

Clinical Studies

Lipid Metabolism – Healthy/Metabolic Syn. (600mg/12 wk; DBRC; n=102)

• Supports healthy liver function
• Supports healthy weight management*
• Reduces liver congestion
• Promotes healthy uric acid levels*

Metabolic Health – DM, Type 2 (600 mg/16 wk.; DBRC; n=80)

• Protects liver cells from oxidative stress
• Protects liver cells from inflammation

Weight Management – Obesogenic mice (100 mg/kg ~ 600 mg HED/d; Control; n=24)

• ↑Brown:white fat ratio (promotes thermogenesis)
• ↓Total and LDL cholesterol
• ↑PPARγ and ↓NFκB

Bioavailability/Synergism (In-house data; mice)

• 1.5X > standalone extracts

Clinical study benefits

Liver specific biomarkers

Storage & Handling

Shelf Life

3 years

Storage Information

• Store in a cool, dry place and away from direct sunlight.
• Shelf Life: Retest 3 years from date of manufacturing.