Granutol® S

Identification & Functionality

Chemical Name

Mannitol

Pharma & Nutraceuticals Functions

Filler

CAS No.

87-78-5

EC No.

201-770-2

Technologies

Pharmaceuticals & Nutraceuticals

Product Families

Pharmaceuticals & Nutraceuticals — Excipients

Fillers & Diluents,

Other Excipients

Features & Benefits

Product Highlights

• 100% D-mannitol granules made from stable β-type crystals.

D-mannitol crystal shapes are known to have 3 types: α-type, β-type and δ-type. β-type is said to be the most stable of these.

• Granutol is useful for water-unstable and Maillard reaction-prone API.

100% D-mannitol granules are chemically stable and have almost no free water. Therefore, it is useful for reactive API.

• Suitable for direct compression as it has excellentformability and fluidity.

As it has high formability, there is no capping even in high compression pressure. In addition, fluidity is also high so it is useful for direct compression

Product Performance

Applications & Uses

Markets

Healthcare & Pharma

Applications

Healthcare & Pharma — Drug Delivery & Care Solutions

Oral

Dosage Form

Tablets

Manufacturing Technology

Direct Compression

Properties

Physical Form

Powder,

Solid

Typical Properties

	Value	Units	Test Method / Conditions
Bulk density	0.55	g/mL	—
Angle of repose	33 °	—	—
Particle Size Distribution (D10)	41	μm	—
Particle Size Distribution (D50)	83	μm	—
Particle Size Distribution (D90)	147	μm	—
Angle of Repose	33	°C	—

Regulatory & Compliance

Certifications & Compliance

Japan Pharmacopeia (JP)

Grade

Pharma Grade

Technical Details & Test Data

SEM Image