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GENOFOCUS Mutanase

GF01 Mutanase is a mutanase preparation derived from Trichoderma sp. The enzyme catalyzes the hydrolysis of α-1,3 Glucan(Mutan), which is main substance of dental plaque. Dental plaque is biofilm, formed by bacteria, salivary glycoproteins and sticky glucose polymers that adhere to tooth surfaces. About 85% of glucose polymers of dental plaque is mutan(α-1,3 Glucan) and remaining 20% is dextran(α-1,6 Glucan).

Functions: Film Former

Benefit Claims: Antiseptic, Excellent Stability

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Identification & Functionality

Chemical Family
Cosmetic Ingredients Functions
CAS No.
9075-84-7
Chemical Structure

GENOFOCUS Mutanase - Chemical Structure

Source

Trichoderma sp.

Features & Benefits

Applications & Uses

Application Format
Oral Care Applications
Application of Mutanase
  • Conventional dental care products( tooth paste , antiseptic mouthwash, etc.) contain Dextranase (α 1,6 Glucanase ). So, dextran can be easily decomposed by conventional dental care products.
  • However, mutan, the main structure of dental plaque which is water insoluble, can not be decomposed by dextranase and remains in the mouth.
  • Mutanase can decompose dental plaque mutan. So, it can be applied to dental care products.

Properties

Physical Form
Appearance
Yellow to light brown powder
Insoluble in
Water
Characteristics
ValueUnitsTest Method / Conditions
Activitymin. 350,000 unit/g

Technical Details & Test Data

Stability Test for Temperature and pH

Heat Stability / Activity

GENOFOCUS Mutanase - Stability Test For Temperature And Ph

 

pH Stability / Activity

GENOFOCUS Mutanase - Stability Test For Temperature And Ph - 1

Recommendation of Operational Condition
  • Stable pH range: pH 4.0 ~ 6.5
  • Optimum pH: pH 5.0 ~ 5.5
  • Temperature stability: stable at 70
  • Optimum temperature: 20~45
Competitiveness of GF Mutanase
  • GF mutanase has CBD(carbohydrate binding domain), whereas conventional mutanase doesn’t have. So, decomposition rate of GF mutanase is superior than the others.
  • Can be easily mixed with various oral hygiene agents such as toothpaste, mouthwash, etc
  • Securing long term storage stability as a raw material for the end products
  • Excellent oral plaque removal effect when applied with dextranase which decomposes water soluble glucan

Schematic model of what mutanase look like

GENOFOCUS Mutanase - Competitiveness of Gf Mutanase*Source: National Renewable Energy Laboratory

 

Dental plaque decomposition effect

GENOFOCUS Mutanase - Competitiveness of Gf Mutanase - 1

Packaging & Availability

Package
  • Package unit: 1 KG, 5 KG
  • Available in both liquid and powdered forms

Storage & Handling

Shelf Life
12 Months
Storage

Store under cool and dry condition.