Knowde Enhanced TDS
Identification & Functionality
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 501-98-4
- Molecular formula
- C9H8O3
- Technologies
- Product Families
- Chemical Structure
Features & Benefits
- Benefit Claims
- Why choose Viablife P-Coumaric Acid
- Viablife produces P-Coumaric Acid using leading fermentation process.
- Our P-Coumaric Acid has the highest purity so far(>99%).
Applications & Uses
- Markets
- Applications
Properties
- Appearance
- White To Light Yellow Powder
- Typical Properties
- Specifications
- Anti-Bacteria
P-Coumaric Acid shows good ability in inhibiting growth of several microbe.
p-coumaric acid (µg/ml))
Gram-positive bacteria
Streptococus pneumoniae 20 Staphylococcus aureus 20 Bacillus subtilis 20 Gram-negative bacteria
Escherichia coli 80 Shigella dysenteriae 10 Samonella typhimurium 20 Lou Z, Wang H, Rao S, et al. P-Coumaric acid kills bacteria through dual damage mechanisms[0]. Food Control, 2012, 25(2):550-554 The p-coumaric acid was tested for antibacterial potential against Gram-positive (S. pneumoniae ATCC49619, B. subtilis 9372, S. aureus 6538) and Gram-negative bacteria (S. dysenteriae 51302, E. coli ATCC25922, Salmonella typhimurium 50013). The MIC values for p-coumaric acid are shown in Table 1. A comparison of the sensitivities of the bacterial strains to p-coumaric acid indicated that the strongest inhibitory effect was against S. dysenteriae. pCoumaric acid showed MIC value of 10 mg/ml in the case of S. dysenteriae
| Value | Units | Test Method / Conditions | |
| Assay | min. 99.0 | % | - |
| Heavy Metals (as Pb) | max. 20 | ppm | - |
| Loss on Drying | min. 0.5 | % | - |
| Purity | min. 99 | % | HPLC, LC-MS |
| Value | Units | Test Method / Conditions | |
| Molecular Weight | 164.16 | - | - |
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
Technical Details & Test Data
- Anti-Melanogenic
P-Coumaric Acid has the optimal structure to be a competitive inhibitor of tyrosinase that catalyzes key reactions in the melanin biosynthetic pathway,thus it has good potential to be used as a skin-lightening active ingredient in cosmetics.
Yong Chool Boo,p-Coumaric Acid as An Active Ingredient in Cosmetics: A Review Focusing on its Antimelanogenic Effects[|]. Antioxidants 2019, 8, 275 p-Coumaric acid can attenuate skin hyperpigmentation through multiple mechanisms. UV and other pathophysiological conditions stimulate the production of reactive oxygen species (ROS) and multiple signaling pathways leading to enhanced gene expression of tyrosinase and increased melanin synthesis. The melanin can absorb ultraviolet (UV) radiation and alleviate oxidative stress and inflammatory reactions caused by UV radiation, but the melanin deposition may cause skin pigmentation disorders. p-Coumaric acid has a chemical structure similar to L-tyrosine and inhibits the activity of tyrosinase, which catalyzes the oxidation of L-tyrosine and/or L-DOPA to L-DOPA quinone in the melanin biosynthetic pathway. Due to its UV absorption and antioxidant action, p-coumaric acid can inhibit the signaling pathways linked to gene expression of tyrosinase and inflammatory mediatorS. p-Coumaric acid can also reduce the stimulatory effects of hormones and L-tyrosine on the gene expression of tyrosinase. Thus, it is proposed that p-coumaric acid has advantageous biochemical properties suitable for use as a skin-lightening active ingredient in cosmetics.
- Anti-Oxidant
P-Coumaric Acid has radical scavenging ability in DPPH and ABTS experiments.
Shen Y, Song X, LiL, et al. Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluationD]. Biomedicine & Pharmacotherapy, 2019 (A) DPPH-radical scavenging activities of p-CA (positive contro-Trolox). (B) ABTS-radical scavenging activities of p-CA (positive contro-Trolox), (C) Ferric ion reducing ability of plasma (FRAP) assay of p-CA (positive contro-Trolox). (D) Metal-ion chelating ability assay of p-CA (positive contro-EDTA).