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Incospharm was founded in 2011 and is continually developing peptides for anti-wrinkle, moisturizing, anti-oxidant, and brightening of the skin. AQUATIDE has significant activity of cellular autophagy induction, enabling and maintaining healthier skin. Active ingredients for sensitive and troubled skin where aging process is faster than normal skin are also under development for cosmetics or pharmaceutical applications. Incospharm has partnered with Arysta Health and Nutrition Sciences (Tokyo, Japan) for global sales and marketing since its foundation.

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Natural moisturizing factor (NMF) in the stratum corneum has a high moisture retaining efficacy, and plays a major role in the skin barrier function.
Pyrrolidone carboxylic acid (PCA) is one of the major NMFs found in human skin.
Aquatide, PCA-mimetic peptide, increases moisturisation, activates autophagy, reduces Trans Epidermal Water Loss (TEWL) and improves the skin barrier function.

Aquatide

AdipoSOL

AdipoSOL™ 2000 is a novel anti-photoageing ingredient that protects the skin from UV stress through autophagy induction and adiponectin expression in skin cells. Shifting of MED proves its skin protection against UV. UV exposure decreases the expression of adiponectin, a well-known adipokine, secreted by adipocytes, leading to the exacerbation of photoageing by stimulating MMP-1 expression and inhibiting procollagen synthesis. Thus the repeated skin damage and imperfect repair caused by UV exposure results in “photoageing” and “inflammageing”.

AdipoSOL™ 2000

Incospharm Corporation Pineapple Ceramide is the major intercellular lipid filling the gaps in corneocytes of horny layer, the outer layer of skin, and plays an important role in suppression of transepidermal water loss, skin barrier function to interrupt invasion of foreign substances or maintenance of skin structure. It is known that ceramide decreases with aging or atopic dermatitis.

Incospharm Corporation Pineapple ceramide

Incospharm Corporation PolluxCD is a novel natural extract that protects the skin against various air-pollution stress (PM, BaP, Heavy metals, UVB) and prevents pollution-induced skin aging.

Incospharm Corporation PolluxCD

Incospharm Corporation Glyceryl Glucoside is a conjugated molecule of glycerol and glucose, and was originally found to be critical for cyanobacteria survive in extremem conditions. Recently, many scientific reports suggested the key role of glyceryl glucoside in induction of aquaporin-3 protein, which is an essential protein in water molecule transport across the skin cell membrane. Glycerol glucoside is becoming the new molecule for next generation moisturizing ingredient.

Incospharm Corporation Glyceryl glucoside

Incospharm Corporation MelaTrepein are transferred to neighboring keratinocytes and then naturally degraded by autophagy. However, when the skin is constantly exposured to sunlight, pathogens, and hormone changes, the intracellular organelles and enzymes lose their functions and, as a result, melanosomes can not be degraded down. Accumulation of undegraded melanosomes in keratinocytes results in skin pigmentation.

Incospharm Corporation MelaTrepein

Aquatide 5000 is the first known peptide-derived SIRT1 activator, activates SIRT1 by direct interaction. Through this interaction AQUATIDE 5000 increases a deacetylation of SIRT1 target protein FoxO1, resulting in the cell protective autophagy.

Aquatide 5000

Incospharm Corporation Wasabi Flavone is the typical herbal medicinal spice originated in Japan known for its anti-bacterial and anti-toxin activities. These activities are due to a special flanovoid called isosaponarin identified from the wasabi flavones extract. Wasabi flavones not only facilitates intracellular collagen biosynthesis, but also helps collagens to form triple helix structure, which is essential for wrinkle reduction and enhanced elasticity of the skin.

Incospharm Corporation Wasabi Flavone

Incospharm Corporation rhEGF is a member of the EGF-like family of proteins. It stimulates the growth and differentiation of fibroblasts and epithelial cells, and plays a role in the development and regeneration of various tissues. EGF is synthesized as a precursor protein that remains anchored to the cell surface. Release of the soluble form occurs through a process known as ectodomain shedding, which involves cleavage of the extracellular domain by the proteins disintegrin and ADAM17. EGF signals via EGF receptor (EGFR, ErbB1 or HER1), which is a type 1 tyrosine kinase receptor and can also bind several other EGF-like proteins. Binding of EGF to EGFRs trigger receptor dimerization, autophosphorylation and internalization of the receptor-ligand complex. Recombinant human Epidermal Growth Factor, from E.coli, is a 6.2 kDa protein containing 53 amino-acid residues.

Incospharm Corporation rhEGF

Incospharm Corporation Sebodulin restores healthy hydrolipidic film by activation of autophagy in sebocytes, the sebum making cells in skin. Sebodulin also help to alleviate the inflammatory responses by C. acne and to improve the skin barrier function

Incospharm Corporation Sebodulin

Incospharm Corporation

Incospharm was founded in 2011 and is continually developing peptides for anti-wrinkle, moisturizing, anti-oxidant, and brightening of the skin. AQUATIDE has significant activity of cellular autophagy

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