Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Cosmetic Ingredients Functions
- Technologies
Features & Benefits
- Benefit Claims
- Product Highlights
- Activates autophagy
- Activates Sirt1
- Increases water retaining activity
- Increases ROS scavenging activity
- Reduces inflammatory signals
- Reduces TEWL
- Strengthens skin barrier function
- Reduces ACNE symptoms
Applications & Uses
- Markets
- Applications
- Skin Care Applications
- Application
- Sensitive skin care
- Anti-aging
- Anti-oxidant
- Anti-inflammation
- Recommended Dosage
- 1~2% for cream, lotion and essence formulation
- 0.1~1% for masksheet
Properties
- Physical Form
Technical Details & Test Data
- Activity and Efficacy
Activates Autophagy
AQUATIDE 5000 treatment increases LC3 puncta forma- tion (green dots) similar as rapamycin
AQUATIDE 5000 Activates SIRT1
Recombinant SIRT1 and its substrates were mixed with AQUATIDE 5000 and others, and measured the deacetylation activity of SIRT1 using fluoremetric analysis. AQUATIDE 5000 activates SIRT1 enzymatic activity.
Increases Water Retaining Activity
Six volunteers were applied with 2% AQUATIDE 5000 in PEG/ EtOH solution or vehicle for 2 weeks and water retaining activity was measured using corneometer. AQUATIDE 5000 shows water retaining activity and increases skin hydration.
Reduces TEWL(TransEpidermal Water Loss)
Six volunteers were applied with 2% AQUATIDE 5000 PEG/EtOH solution or vehicle for 2 weeks. D-squome was removed using tape stripping, and TEWL was measured using Vapormeter. AQUATIDE 5000 enhances the skin barrier function and prevents water loss singnificantly.
Improves Skin Barrier Function and Anti-ACNE Efficacy
Sixteen volunteers were applied with 1% AQUATIDE 5000 and 0.5% salicylic acid formulation for 4 weeks. Skin conditions were evaluated by dermatologist. AQUATIDE 5000 has a strong anti-inflammatory activity, and reduces average 65% of ACNE symptoms.