Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Ingredient Name
- Ingredient Origin
- Pharma & Nutraceuticals Functions
- Product Families
- Plant Source
Fruit
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Product Overview
- Urinary tract infections (or UTIs in short) are among the most frequent infections worldwide and can be especially challenging due to re-occurrence.
- In this field, among the many available products on the market, Anthocran® Phytosome® is the new benchmark for cranberry extracts, thanks to its standardized nature and accountable PACs content (Source: internal analysis.)
- Now, the latest news is the development and testing of Anthocran® Phytosome® with an optimized pharmacokinetic profile and enhanced performance.
- For the first time, the use of an innovative analytic method has allowed for the identification of valeric acids and valerolactons – which are predicted metabolites of PACs – in human urines after cranberry intake, shining a bright new light on urinary tract wellbeing.
- ANTHOCRAN® PHYTOSOME® Features and Benefits
ANTHOCRAN® PHYTOSOME® contains not only PACs, but maintains the full bouquet of polyphenols contained in natural cranberry juice, acknowledged for its benefits in urinary health.
ANTHOCRAN® PHYTOSOME® is supported by an extensive full characterization of its pharmacokinetic profile in human urines, which are the proper target of V. macrocarpon ingredients effective in urinary health:
- PACs were not detected in urines, in line with other scientific papers
- New metabolites firstly described in human urines (i.e. valerolactones) were detected
- Despite the lower content of PACs, urines fractions rich in this new metabolites were the most active against Candida albicans adhesion and biofilm formation: the innovative formulation was bioequivalent to unformulated cranberry extract in inhibiting the bacterial proliferation, proving the favorable effect of Phytosome® technology on phytoactives absorption.
Two recent findings proven ANTHOCRAN® PHYTOSOME®:
- effective in reducing symptoms and recurrence of UTIs despite the lower PACs content compared to other market formulations
- effective in preserving the physiological intestinal microbiota, retaining the physiological degradation of polyphenols during intestinal microbial metabolism and the formation of colonic biologically active metabolites.
All together the above findings provide new and innovative insights on cranberry extracts, endorsing these new metabolites instead of PACs as the true responsible for cranberry support to urinary health instead of intact PACs as assumed so far.
- Health Benefits
Urinary tract wellbeing
Applications & Uses
- Applications
- Food & Nutrition Applications
- Use Level
- 120 mg/day
Properties
- Physical Form
- Appearance
- Dark purple powder
- Assay
| Value | Units | Test Method / Conditions | |
| PAC's | 6 - 9 | % | Spectrophotometry (DMAC method). |
Technical Details & Test Data
- Clinical Evidence
- The scientific heritage of Anthocran® combines with another milestone technology by Indena, as Phytosome® provides its unique formulation advantage to the iconic cranberry extract.
- The new functional ingredient has already proved its value in delivering the whole bouquet of cranberries’ benefits to the body, actively promoting urinary tract health.
- Furthermore, Anthocran® Phytosome® delivering 9 mg of PACs (proanthocyanidins) has proved to be as effective as unformulated products containing 36 mg of them. This is thanks to Phytosome® technology, which is able to optimize the bioabsorption of phytoactive compounds and their delivery to target tissues.
- Anthocran® Phytosome® into Action
- Scientific evidence supports the claim that Anthocran® Phytosome® is the next game changer in urinary tract health maintenance. In particular, compared to standard treatments, the supplementation of the ingredient in subjects that required post-surgical catheterization favorably rebalanced the urinary tract epithelium and achieved zero UTI re-occurrence.
- Moreover, ex-vivo data confirmed the inhibitory activity of the ingredient on the adhesion of Candida albicans to the urinary tract, proving Anthocran® Phytosome® is a valid aid in keeping one of the most common pathogens under control.