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Indena St. John’s Wort

Indena St. John’s Wort is a dry extract obtained from the flowering top of Hypericum perforatum L. This product is used as an antidepressant in the pharmaceutical industry. This product is CEP-granted, and it helps with balancing mood, anxiety, stress, and sleep.

Ingredient Name: Hypericum Perforatum Flowering Top Extract

Chemical Name: Hypericum perforatum Flowering Top Extract

CAS Number: 84082-80-4

Functions: Anti-Depressant, Phytochemical

Active Component: Flavonoids, Hyperforin, Hypericin

Enhanced TDS

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

Pharma & Nutraceuticals Functions
Plant Source

Flowering top

Extract Type

Dry Extract

Botanical Origin

Hypericum perforatum L.

Features & Benefits

Food Ingredients Features
Health Benefits


Product Overview

Boost the Mood

  • St. John's Wort, a perennial herb, is a well-recognized remedy for mental health conditions since the Greco-Roman times. Nowadays, the main indication is for mild to moderate depression. Botanists recommend SJW also as a mild sedative and nerve tonic for excitability, anxiety and nervous irritability.
  • To note, its mechanism of action is not completely understood. Among the hypothesis, one of them describes a possible significant binding of hyperforin (the main active principle) to GABA A and GABA B, adenosine, MAO and benzodiazepine receptors.
  • In addition, there could be also some effects that inhibit synaptosomal uptake of serotonin (5-HT), dopamine and noradrenaline with some increase in dopamine and noradrenaline. Instead, other studies underline the possible decrease in tryptophan degradation (a 5-HT precursor).
  • Finally, there could be an explanation for the antidepressant effect that considers the inhibition of interleukin-6 (IL-6) by hyperforin and through the inhibition of substance P mediated effects on depression.
  • If literature showed great evidence of efficacy of SJW in treating depression and other mental disorders, some caution could be taken into consideration for possible drug interactions.

Applications & Uses

Food & Nutrition Applications


ValueUnitsTest Method / Conditions
Total Hypericin0.10 - 0.30%HPLC Method
Flavonoidsmin. 6.0%HPLC Method
Hyperforinmax. 6.0%HPLC Method

Regulatory & Compliance

Certifications & Compliance