Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Chemical Name
- Ingredient Name
- Ingredient Origin
- Pharma & Nutraceuticals Functions
- Product Families
- Plant Source
Flowering top
- Extract Type
Dry Extract
- Botanical Origin
Hypericum perforatum L.
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Health Benefits
Antidepressant
- Product Overview
Boost the Mood
- St. John's Wort, a perennial herb, is a well-recognized remedy for mental health conditions since the Greco-Roman times. Nowadays, the main indication is for mild to moderate depression. Botanists recommend SJW also as a mild sedative and nerve tonic for excitability, anxiety and nervous irritability.
- To note, its mechanism of action is not completely understood. Among the hypothesis, one of them describes a possible significant binding of hyperforin (the main active principle) to GABA A and GABA B, adenosine, MAO and benzodiazepine receptors.
- In addition, there could be also some effects that inhibit synaptosomal uptake of serotonin (5-HT), dopamine and noradrenaline with some increase in dopamine and noradrenaline. Instead, other studies underline the possible decrease in tryptophan degradation (a 5-HT precursor).
- Finally, there could be an explanation for the antidepressant effect that considers the inhibition of interleukin-6 (IL-6) by hyperforin and through the inhibition of substance P mediated effects on depression.
- If literature showed great evidence of efficacy of SJW in treating depression and other mental disorders, some caution could be taken into consideration for possible drug interactions.
Applications & Uses
- Applications
- Food & Nutrition Applications
Properties
- Assay
| Value | Units | Test Method / Conditions | |
| Total Hypericin | 0.10 - 0.30 | % | HPLC Method |
| Flavonoids | min. 6.0 | % | HPLC Method |
| Hyperforin | max. 6.0 | % | HPLC Method |
Regulatory & Compliance
- Certifications & Compliance