Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Ingredient Name
- Ingredient Origin
- Pharma & Nutraceuticals Functions
- Product Families
- Plant Source
Rhizome (Zingiber), Aerial part (Acmella)
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Product Overview
- Ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds (gingerols, paradols, shogaols and zingerones) whose major properties embrace immune modulatory, anti-inflammatory, anti-tumorigenic, anti-hyperglycemic and antilipidemic actions.
- Acmella (Acmella oleracea L.) has been used for centuries to treat oral pain because of its analgesic properties. Studies has shown that Spilanthol is the principal compound that promotes local anesthetic action and has many other biological activities such as analgesic, antinociceptive, antioxidant, anti-inflammatory and anti-wrinkle.
- Born from the smart combination of these 2 standardized extracts and exploiting the synergy of this amazing couple, Mitidol® is an innovative natural solution which have been developed to provide an effective ache management support.
- MITIDOL® Features
MITIDOL® is a proprietary association of two standardized botanical extracts able to support ache management.
The innovative composition exploits the properties of two traditionally used plants:
Zingiber officinale
- gignerols and shogaols are the main extract components;
- traditionally used, the plant has a vast scientific literature, with studies documenting their ability to modulate many enzymes involved in the healthy inflammatory response
Acmella oleracea
- Indena proprietary organic plantations in Sardinia
- fully sustainable source of alkylamides
- compliant to main worldwide regulations
- the main component, spilanthol, is effective at low dosages and in literature has shown a plethora of beneficial effects
- Health Benefits
Natural ache relief
Applications & Uses
- Applications
- Food & Nutrition Applications
- Use Level
- 350 mg/day (2x)
Properties
- Physical Form
- Appearance
- Yellowish fine powder
- Assay
| Value | Units | Test Method / Conditions | |
| Zingiber Officinale CO₂ Extract | 9.6 - 11.8 | % | — |
| Acmella Oleracea st. Extract | 1.9 - 2.4 | % | — |
| Spilanthol | 0.30 - 0.60 | % | HPLC Method |
| Total Gingerols and Shogaols | 2.4 - 3.9 | % | HPLC Method |
Technical Details & Test Data
- Mitidol® into Action
- Two recent in vitro experiments has clarified Ginger and Acmella mechanism of action, proving that their combination in the Mitidol® formulation has a double effect on ache relief support: a direct one thanks to the interaction with the cannabinoid receptor CB2 and an indirect one through the inhibition of FAAH enzyme, involved in the physiological ache relief processes.
- Moreover, the powerful combination of the 2 extracts support knee functionality and comfort, according to a one-month human trial conducted on 50 subjects with knee challenge.
- Efficay Study
A one-month human efficay study on joint challenges on MITIDOL® showed:
- optimization of knee functionality confirmed in two different tests: Lhysolm and Womac scale
- effective on knee ache intensity already after 10 days of supplementation
- improvement in Quality of Life score (SF-36 questionnaire)
- improvement in physical activity
- healthy oxidative response control, possibly causing inflammation:
- 12.7% Erythrocyte Sedimentation Rate
- 36.4% high sensitivity CRP
Two mechanistic studies suggested that, , MITIDOL® could selectively act on cannabinoid CB2 receptors compared to competitors like Piper nigrum, Commiphora mhirra and palmitoylethanolamide, and as a possible FAAH inhibitor.