Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Ingredient Name
- Ingredient Origin
- Pharma & Nutraceuticals Functions
- Product Families
- Plant Source
Flower buds
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Product Overview
- Quercetin is a natural flavonoid compound widely found in vegetables, fruits and nuts. Quercefit®, in particular, is derived from the flower buds of Sophora japonica L.3 and shows an activity profile that can be best described as “pleiotropic”, due to its beneficial effects on several and diverse physiological processes.
- For example, in-vitro, in-vivo and human studies have reported that quercetin – the queen of flavonoids – exhibits positive influence on blood circulation, immunity, virus exposure protection, metabolism and, more recently, eye health.
- At cellular level, quercetin shows:
- Antioxidant activity, through the direct inactivation of free radicals, inhibition of lipid peroxidation and inhibition of free radicals producing enzymes.
- Modulation activity on the most important inflammatory cascades, leveling down NF-kB activation, controlling COX and LOX activation and cytokine production.
- Immunomodulation activity hampering histamine release, promoting IFN-γ release and fighting IgE.
- Quercefit® is your Ticket to Ride anywhere, at any time.
- Better Performance and Faster Recovery
In a controlled human study12 on healthy triathlon athletes, QUERCEFIT® demonstrated to support optimal physical performance and prompt recovery:
- statistically significant results in each single triathlon test (swimming, biking, running)
- higher triathlon time reduction (-11.3%) compared to control (-3.9%) after just 14 days of oral supplementation
- reduced discomfort related to sport activity;
- lower oxidative stress (PFR) 1 hr after the final run
- healthy blood levels maintenance, with a reduced UBR and LDH after prolonged sport activity.
- Health Benefits
Antioxidant activity, Eye wellbeing restoration, Immunity, Physical performance, Support in healing corneal and conjunctival trauma, Wellbeing optimization in allergy prone
Applications & Uses
- Applications
- Food & Nutrition Applications
- Use Level
- 250 mg/day (once or twice a day)
Properties
- Appearance
- Yellow powder
- Specifications
| Value | Units | Test Method / Conditions | |
| Quercetin | 34 - 42 | % | HPLC Method |
Technical Details & Test Data
- Quercefit® into Action
Thanks to its original formulation, Quercefit® can hit its targets with far more efficiency than unformulated quercetin. Indeed, it shows optimized bioabsorption and solubility, so it can be used at lower dosages retaining efficacy with no undesirable side effects.
Let’s see how it works.
Immunity Health and Senolytic Function
- Recent studies show that Quercefit® helps maintain immune system health and modulates cytokine cascade. Thus, it improves the conditions of those exposed to Covid-19, precisely thanks to its senolytic function: its supplementation helps people maintain healthy condition in a Sars-CoV-2 infectious environment. While the standard precautionary measures and treatments defined by medical protocols cannot be replaced, the severity of symptoms often depends on the way the initial phases of the illness are faced.
- This evidence has been confirmed by recent human studies that showed how Quercefit® can support the immune system, even in the presence of Covid-19 infection, in terms of virus clearance optimization and milder symptoms.
Allergies
- Quercefit® is a natural remedy during allergy season, promoting the wellbeing of sensitive and intolerant subjects in periods when allergens are abundant and widespread. A wish come true for all allergy-prone people.
- And its potential against allergies doesn’t end there: a recent study on mildly symptomatic individuals highlighted that Quercefit® significantly preserves eye and nose from discomforts and improves overall quality of life.
Eye Health
Healthy ocular physiology in people experiencing allergic conjunctivitis, treated with continuous anti-allergy medications. Once again, the benefits of Quercefit® are tied to effective target delivery, provided by the unrivaled Phytosome®. Furthermore, a series of case studies has highlighted that the oral administration of Quercefit® during topical antibiotic therapy on ocular tissues, damaged by mechanical, thermal or chemical trauma, can support faster restoration. The faster the better, when it comes to eye health.
Physical Performance
In triathlon athletes using Quercefit®, study have pointed out an optimization of training and performance and a leveling in oxidative stress. Quercefit® is the right partner to support optimal physical performance and prompt recovery.
- Immunity Health, Senolytic Function And Covid-19
- A recent randomized, placebo-controlled, double-blind parallel-group study, aimed to investigate the effects of a 4-week oral intake of quercetin Phytosome® on physiological parameters and relative subjective feelings in Japanese adults who complained of diskomfort in the eyes and nose.
- After the subjects were given 250 mg of QUERCEFIT® twice daily or the placebo for 4 weeks they experienced a favorable healthy status for their eyes and nose. Furthermore, the quality of life of these subjects significantly improved and it has been proven a beneficial effect on immune and inflammatory processes in the upper respiratory tract, main way in for allergens and pathogens.
- Taking inspiration from the interesting Japanese study outcomes , a new investigation8 has been designed to deep dive the role of quercetin as a beneficial supplementation when allergic ocular diskomfort may occur.
- The results show that dietary supplements may play a relevant role in the future treatment of allergic conjunctivitis, thanks to proved evidence of their effectiveness and safety.
- In particular, there are evidences that supplementation with QUERCEFIT® may favorably mitigate unbalanced ocular conditions and as stand alone supplementation to preserve eye health over time after allergic symptomatology. In a controlled human study on diskomforts during allergy season, after 30 days of supplementation with QUERCEFIT® plus the standard management (SM) versus the SM alone, it has been demonstrated:
- up to 50% reduction of day intermittent diskomforts frequency
- up to 70% reduction of night intermittent diskomforts frequency
- maintenance of breath function (Peak Expiratory Flow) at physiological levels in mild-persistent diskomforts
- In another controlled human study focussing on local skin diskomforts, QUERCEFIT® was administrated for just 3 days, then followed by a local histamine skin stimulus.
- Compared to the control, only the healthy volounteers administered with the extract showed statistically significant:
- dose-dependent control of all main local conditions
- skin conditions amelioration and capillary filtration reduction
- The Natural Remedy in the Allergy Era
- A recent randomized, placebo-controlled, double-blind parallel-group study, aimed to investigate the effects of a 4-week oral intake of quercetin Phytosome® on physiological parameters and relative subjective feelings in Japanese adults who complained of discomfort in the eyes and nose.
- After the subjects were given 250 mg of QUERCEFIT® twice daily or the placebo for 4 weeks they experienced a favourable healthy status for their eyes and nose. Furthermore, the quality of life of these subjects significantly improved and it has been proven a beneficial effect on immune and inflammatory processes in the upper respiratory tract, main way in for allergens and pathogens.
- Taking inspiration from the interesting Japanese study outcomes , a new investigation8 has been designed to deep dive the role of quercetin as a beneficial supplementation when allergic ocular discomfort may occur.
- The results show that dietary supplements may play a relevant role in the future treatment of allergic conjunctivitis, thanks to proved evidence of their effectiveness and safety.
- In particular, there are evidences that supplementation with QUERCEFIT® may favourably mitigate unbalanced ocular conditions and as stand alone supplementation to preserve eye health over time after allergic symptomatology. In a controlled human study on discomforts during allergy season, after 30 days of supplementation with QUERCEFIT® plus the standard management (SM) versus the SM alone, it has been demonstrated:
- up to 50% reduction of day intermittent discomforts frequency
- up to 70% reduction of night intermittent discomforts frequency
- maintenance of breath function (Peak Expiratory Flow) at physiological levels in mild-persistent discomforts
- In another controlled human study focussing on local skin discomforts, QUERCEFIT® was administrated for just 3 days, then followed by a local histamine skin stimulus.
- Compared to the control, only the healthy volounteers administered with the extract showed statistically significant:
- dose-dependent control of all main local conditions
- skin conditions amelioration and capillary filtration reduction