Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
- Sustainability
Naturality according to ISO16128 99.5% natural origin content
Features & Benefits
- Benefit Claims
- Benefits
- Strengthening the double barrier function: skin and microbiome
- Minimizing desquamation on body, hands and scalp
- Scalp benefits perceived from the first application
- Product Highlights
Science
- Urban life, linked to reduced exposure to nature, and hypercleanliness practices are daily aggresors that have shown to increase the risk of skin and scalp conditions. Discomfort, dehydration and scaling are characteristics of sensitive or damaged skin and scalp, lacking an effective defense system. To promote healthier and younger skin and scalp, a balanced microbiota and reinforced skin barrier function are important.
- Fensebiome™ peptide helps to boost the defense system of the skin and scalp by favoring the presence of beneficial bacteria and by improving the skin immune response and the physical barrier integrity. In skin, it re- inforced cell cohesion to reduce skin scaliness and had a barrier protective effect. It even protected hands during use of sanitizer gels. In scalp, it increased hydration and reduced inflammation to give relief to sensitive scalps for both men and women.
Applications & Uses
- Markets
- Applications
- Skin Care Applications
- Use Level
- 1%
Properties
- Appearance
- Translucent solution containing 0.05% Acetyl Heptapeptide-4.
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- In Vitro Efficacy
Results:
- Supporting a healthy skin microbiota
- Reinforced skin barrier to resist damage
- Improved cutaneous immune system
- Relief of inflammatory conditions
- In Vivo Efficacy
Skin:
- Study of microbiome composition
- 21 urban women applied a cream with 1% Fensebiome™ peptide solution or a placebo cream on the cubital fossa of the arm twice a day for 7 days. Metagenomic analysis was performed to evaluate the changes in microbiota relative abundance.
- Barrier protection effect
- 20 women applied a cream with 1% Fensebiome™ peptide solution or a placebo cream on the volar part of the forearm twice a day for 7 days. The transepidermal water loss (TEWL) was evaluated after surfactant damage.
- 20 women applied a cream with 1% Fensebiome™ peptide solution or a placebo cream on the volar part of the forearm twice a day for 7 days. The transepidermal water loss (TEWL) was evaluated after surfactant damage.
Results:
- Balanced microbiota for a healthy and protected skin
- Better protection to prevent dehydration 53.6% lower TEWL values versus placebo.
Scalp:
33 women from 50 to 65 years applied a serum with 1% Fensebiome™ peptide solution or a placebo serum on wet scalp twice or three times a week for 28 days.
- Modulation of age-induced changes in microbiota
- Lower TEWL values
- Increase of IL-1 receptor antagonist, an inhibitor of inflammation that decreases with aging
Results:
- Boost in inhibitors of inflammation to help alleviate sensitive scalp
- Enhanced scalp barrier protection effect
Soothing effect when most needed:
Skin protection from hand sanitizers 44 women with dry, damaged and/or sensitive skin on hands applied a hand sanitizer with 1% Fensebiome™ peptide solution or a placebo hand sanitizer 5 - 8 times a day for 7 days.
Minimized desquamation
Bald sensitive scalp relief 14 men with bald sensitive scalp applied a serum with 1% FensebiomeTM peptide solution on scalp once a day for 28 days.
Results:
- Protecting the skin from the drying effects of hand sanitizers
- Bald sensitive scalp comfort perceived from first application and enhanced with continuous use
- Study of microbiome composition