Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Lactobacillus Plantarums
- Product Families
- Strain Origin and History
Vivoflora’s Lactobacillus plantarum LMTM strain was isolated in 2005 at the Kiev National Technical University by the Biotechnology faculty. The strain was isolated from a soy flow fermentation in which a combination of strains from commercial products was used. This particular strain was chosen to isolate and research because of its fast and impressive growth qualities in soy based media. It was found that the soy components induce the immune activity of this strain. The immune activity was found to be higher when grown in soy based media than in casein (milk) based media. The L. plantarum LM strain of Lactobacillus plantarum was included in PhD research (Starovoitova Svetlana, Kiev Technical University, Biotechnology Department). This research focused on the adhesion, antagonistic and immune activity of some strains, including the newly isolated LM strain. This strain, originally as an industrial strain, was used as a reference and has shown promising therapeutic qualities.
Features & Benefits
- Product Highlights
FUNCITONAL CHARACTERISTICS AND EFFICACY
The L. plantarum LM™ strain of Lactobacillus plantarum assists the restoration and balancing of intestinal microbiota, inhibition of growth of pathogenic bacteria, supports the immune system, works well in combination with less active probiotic strains, and is highly adapted to vegetarian diets.
Digestive Health Functionality
Vivoflora’s Lactobacillus plantarum LM™ strain has high levels of survival in the human intestine as well as high resistance to bile salts, gastrointestinal enzymes and acids, and exhibits good adhesion properties in vivo. It also exhibits significant levels of proteolytic activity to allow for better digestion of plant and animal protein. The LM strain is highly adapted to vegetarian diets.
Protective Functionality
The L. plantarum LM™ strain of L. plantarum demonstrates antagonistic activity against pathogenic and conditionally-pathogenic microorganisms and thereby creates favorable conditions for the development of useful gastrointestinal microflora and stimulates the growth of the host microbiota. The LM strain exhibits effective levels of antagonistic activity against Gram positive and Gram Negative pathogens including pathogens found in hospital infections, post operative infections and complications such as Salmonella, Escherichia, Staphylococcus, and Proteus genus. Good antagonistic activity is also demonstrated against food spoilage microorganisms.
Immune Modulation
Vivoflora’s Lactobacillus plantarum LM™ strain demonstrates a high level of non-specific immune activity. It stimulates phagocyte activity, induces IFN and NK cells production.
Anti-Mutagenic and Antibiotic Tolerant Properties
The LM strain exhibits significant anti-mutagenic properties, good tolerance to Amikacin, Streptomycin, Gentamycin, and low sensitivity to Penicillin and Levofloxacin.
Applications & Uses
- Markets
- Food & Nutrition Applications
- Target Application
Good for daily health maintenance and the prevention of serious health problems. This strain can be used for milk, soy and other vegetable products.
Regulatory & Compliance
- Certifications & Compliance
- Strain Authenticity & Deposit
According to FAO/WHO, Vivoflora’s Lactobacillus plantarum LM™ strain has been identified as Lactobacillus plantarum by use of phenotypic characterization, carbohydrate utilization or fermentation profile, and genetic ribotype techniques. This strain has been deposited in the NTU Biotechnology Department Collection as L. plantarum.
Technical Details & Test Data
- Clinical Studies
L. plantarum LM™ strain of Lactobacillus plantarum was derived from a root L. plantarum strain for which clinical studies have been conducted.
Safety & Health
- Safety Assessment
A safety assessment has been performed for acute and chronic toxicity using rats and mice. The LD50 in acute testing was >20g/kg body mass. A culture of this strain is safe and non-toxic. The L. plantarum LM™ strain of L. plantarum is a strain that has been commonly used since prior to 1994, and its safe use in dietary supplements is FDA compliant under the Dietary Supplement Health and Education Act of 1994 (DSHEA)