MacPeptide - Syn6 - McKinley Resources - Caprylyl Glycol

Knowde Enhanced TDS

Identification & Functionality

Carrier: Aqua,
Glycerin
INCI Name: Caprylyl Glycol,
Ethylhexylglycerin,
Hydroxypropyl Cyclodextrin,
Palmitoyl Tripeptide-38,
Trehalose
Cosmetic Ingredients Functions: Anti-Aging Agent,
Anti-Wrinkle Agent
Technologies: Cosmetic Ingredients
Product Families: Cosmetic Ingredients — Cosmetic Actives
Skin Actives

Features & Benefits

Benefit Claims: Anti-Aging,
Anti-Wrinkle,
Collagen Boosting,
Moisturizing,
Repairing,
Skin Tightening,
Smoothing,
Smooths Wrinkles,
Wrinkle Prevention
Labeling Claims: Clean at Sephora,
Credo Clean Standard
Benefits & Features: Anti-Wrinkle

Restructures and Repairs Skin Tissue

Skin Moisturization

Applications & Uses

Markets: Personal Care
Applications: Personal Care — Beauty & Care
Skin Care,
Treatment Products
Application Format: Creams,
Leave On,
Lotions,
Serum
Skin Care Applications: Anti-Aging Products,
Body Cream,
Body Firming Lotion,
Eye Serum,
Moisturizers,
Skin Serums
Treatment Product Applications: Wound Treatment
Use Level: 0.5 - 10 %
Applications: Serum

Skin Creams

Eye Cream

Solultions

Properties

	Value	Units	Test Method / Conditions
Peptide Content	0.02 - 0.03	%	—
pH	4.0 - 6.0	—	—

Technical Details & Test Data

Efficacy Testing: In-vivo testing of effect on decreased wrinkle depth using cream containing 2% MacPeptide™ Syn-6

Twenty-five female volunteers with mature skin (ages 42-70) applied a randomized treatment of MacPeptide™ Syn-6 or a placebo twice daily for two months.

Forehead Results

Items
Volume (mm³)
Roughness (%) Deepest wrinkle (μm)

T0 T 2 months T0 T 2 months T0 T 2 months

Average ±
standard deviation 3.12 ± 1.68 2.16 ± 1.54 1.25 ± 0.92 0.90 ± 044 124 ± 57 103 ± 30

Change (%)
most significant
observation -31% p=0.055 AE -100% -28% p<0.05 AE-77% -16.3% p<0.05 AE-62%

Eye Area Results

Items Volume (mm³) Deepest wrinkle (μm)

T0 T 2 months T0 T 2 months

Change (%)
most
significant
observation -21.1% p<0.05 -28.5% p<0.05

Results:

Forehead wrinkle volume depth decreased 31% and 16% in volume in the deepest wrinkle

Roughness decreased by 28% in the forehead area

Eye wrinkle volume depth decreased 21% and 28% in volume in the deepest wrinkle

Items	Volume (mm³)		Roughness (%)		Deepest wrinkle (μm)
	T0	T 2 months	T0	T 2 months	T0	T 2 months
Average ± standard deviation	3.12 ± 1.68	2.16 ± 1.54	1.25 ± 0.92	0.90 ± 044	124 ± 57	103 ± 30
Change (%) most significant observation	-31% p=0.055 AE -100%		-28% p<0.05 AE-77%		-16.3% p<0.05 AE-62%